Objective:To study antidepressant effects of “Compound Danshen Dripping Pill” (FDD) on lipopolysaccharide (LPS)-induced depressive-like behaviors in mice. MethodsTo observe the influence of FDD high dosage (270 μg/g) and low dosage (135 μg/g) on open field test (OFT) and forced swim test (FST) in depressive-like behavior model mice induced by LPS injection, furthermore, to detect interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha) and interleukin 10 (IL-10) levels in serum and cerebral cortex, explain antidepressant mechanism of FDD from its effects on inflammatory cytokines in depression model.  Results:High dosage of FDD can obviously improve the decrease of moving distances in OFT induced by LPS injection, and both of high and low dosage of FDD can remarkable increase the decreasing of rearing times induced by LPS, as well as decrease the improvement of immobility time of mice in FST induced by LPS. All of these results are statistically significant (P<0.05). In serum, each dosage of FDD can significantly reduce IL-6, TNF-α level improvement, and increase IL-10 decrease induced by LPS with statistically significant (P<0.05, P<0.01). In cerebral cortex, each dosage of FDD can significantly reduce IL-6 level improvement induced by LPS (P<0.01), high dosage of FDD can obviously reverse the improvement of TNF-α level induced by LPS (P<0.05), and both of high dosage (P<0.01) and low dosage (P<0.05) can obviously reverse IL-10 level increase.  Conclusion:The improvement effects of FDD on depressive-like behaviors mice model induced by LPS may be related to its anti-inflammation and immune system regulation effects, and its mechanism needs further research.