Objective:To observe the clinical efficacy of “Qutan Qingwei Decoction” in the treatment of simple obesity of damp-heat accumulation. MethodsEighty subjects were randomized into two groups:control group in which 40 were given dietary control and exercise therapy, and observation group in which 40 cases were given “Qutan Qingwei Decoction” as well as dietary control and exercise therapy, with a course of 12 weeks. The clinical efficacy, body weight and fat rate, and the levels of triglyceride (TG), total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) were observed.  Results:The overall effective rate was 30.0% in the control group and 80.0% in the observation group, with better efficacy in the observation group than in the control group(P<0.05). After treatment, the body weight and fat rate were reduced in both group (P<0.05), with more significant reduction in the observation group than in the control group (P<0.05). After treatment, in the observation group, the levels of TG and TC were decreased (P<0.05) and the level of HDL-C increased (P<0.05), with more significant improvement in the observation group than in the control group (P<0.05).  Conclusion:“Qutan Qingwei Decoction” is quite effective in the treatment of simple obesity and in improving blood lipids.