Objective:Through exploring the influence of the traditional Chinese medicine “Penyan Fang” on the expression of transforming growth factor-pi (TGF-β,1,) and its transforming growth factor-β receptor Ⅱ (TβR Ⅱ) in the uterine tissue and ovarian tissue of the female rats with sequelae of pelvic inflammatory disease to probe the functional mechanism of the “Penyan Fang”. Methods124 SD female rats were treated as the subjects and were randomly extracted 10 female rats as the blank group, 10 female rats as the sham operation group. After making models successfully,rat models were randomly divided into model group for 15 rats,Fuke Qianjin Capsule group for 15 rats,Penyan Fang high, medium and low dose groups for every 15 rats. Observing the change of the uterus tissue morphology under HE dyeing,and using the immunohistochemical method to observe the expressions of TGF-β,1, and TβR Ⅱ of the rats in all groups after drug intervention for 21days.  Results:Compared with the blank group and sham operation group, the expression of TGF-β,1, and TβR Ⅱ in the uterine tissue and ovarian tissue of the female rats increased in model group, and there was significant difference between the groups(P,<,0.01). Compared with model group, Fuyan Fang different dose groups and Fuke Qianjin Capsule group could reduce the expression of TGF-β,1, and TβR Ⅱ in the uterine tissue and ovarian tissue of the female rats with sequelae of pelvic inflammatory disease,the difference between them was significant(P,<,0.05,P,<,0.01), the effects of Penyan Fang high dose group were the best, and the effects was equal to Fuke Qianjin Capsule group.  Conclusion:Panyan Fang can treat sequelae of pelvic inflammatory disease may through decreasing the expression of TGF-β,1, and TβR Ⅱ in the uterine tissue and ovarian tissue and elieving and diminishing local inflammation.