This paper introduces Master Qiu Peiran’s clinical experience in the prescription of herbal paste, including accurate differentiation of diseases, comprehensive treatment of big and heavy prescription, nourishment of spleen and kidney, combined use of reinforcing and reducing methods, combination of heat and cold herbs, integration of static and motive herbs, and joining of astringing and dispersing herbs. One case of duodenal ulcer treated by herbal paste was presented as an example.