Objective:To evaluate the effect of “Wuxing Jiangu Cao” on quality of life in patients with postmenopausal osteoporosis. MethodsTotally 78 patients with postmenopausal osteoporosis were randomly divided into control group and observation group, 39 cases in each group. The control group was treated with oral alfacalcidol and calcium carbonate D3, while the observation group was treated with “Wuxing Jiangu Cao” on the basis of the control group.180 days for both the groups. OQOLS was observed before and after treatment.  Results:After the treatment, the scores of each project and total score of OQOLS in each group were significantly decreased (P<0.05), and the scores of observe group were lower than that of control group (P<0.05).  Conclusion:“Wuxing Jiangu Cao” can improve quality of life in patients with postmenopausal osteoporosis.