Objective:To investigate the Effects of Kangxianling prescription on renal function By Hypertensive renal damage in mice. Methods60 mice with blood pressure were randomly divided into 5 groups. The Model group,fosinopril group, Kangxianling group of them underwent unilateral nephrectomy and infusion of angiotensin II using a micro-osmotic pump. The normal group was not treated, physiological saline control group underwent unilateral nephrectomy and infusion of physiological saline using a micro-osmotic pump. Each group were fed ad libitum, Kangxianling group with Kangxianling prescription administration by gavage once a day ; Monopril group were given Monopril by gavage once a day; the rest of the group fed tap water. After 4 weeks of treatment,detected the killed mice. Urine of laboratory mice in each group was collected to measure 24-hour urine protein quantitative. The blood taken from orbital venous was used to test serum creatinine (Scr),blood urea nitrogen(BUN).  Results:The experiment in the second week The levels of blood pressure in Kangxianling group and monopril group decline compared with those in the model group(P<0.05).The experiment in the fourth week The levels of blood pressure in Kangxianling group and monopril group decline compared with those in the model group(P<0.05).The levels of Scr in model group and saline control group significantly increased compared with those in the normal group (P<0.05);the BUN levels in the model and monopril group of significant increases than the normal group (P<0.05);and the 24-hour urine quantitative protein in the normal group、saline control group and monopril group all decreased significantly compared with those in the normal group(P<0.01).  Conclusion:This study shows that fiber resistance spirit can reduce blood pressure in mice,Kangxianling can improve the hypertensive renal damage mice renal function.