Objective:To detect the immune induced Sjgren’s syndrome model rat’s CD4,+, CD25,+, Foxp3T cells (Treg) and Th17 cell level from peripheral blood,at the same time observe the improvement of the affected glands and the changes of peripheral blood lymphocyte subsets. MethodsMale BABL/C mice were divided into blank group, model group, hydroxychloroquine group and “Shengjin Renzao Prescription” high, middle, low-dose groups. The mice in all the groups except the blank group were established the sjogren’s syndrome in mice model by the immune inducing. Each group was intervened respectively. The level of CD4,+,、CD8,+,、CD4,+, CD25,+, Foxp3T cells and Th17 cell in the peripheral blood of mice was detected by using flow cytometry,and saliva,tear secretion of model rats was determined; At the end of its treatment,observe the change of submaxillary gland tissue morphology.  Results:Compared with blank group, saliva and tear secretion of the mice from the first week to the fourth week in the model group decreased obviously(P,<,0.05)；compared with model group, saliva and tear secretion of the mice in “Shengjin Renzao Prescription” each dose group increased from the second, the third and the fourth week(P,<,0.05). Compared with blank group, the level of Th17 lymphocyte cell in model group increased(P,<,0.05). Compared with model group, “Shengjin Renzao Prescription” each dose group can increase level of CD8,+,T lymphocyte cell and decrease Th17 lymphocyte cell, and increase level of Treg cell, and there was significant difference(P,<,0.05). The morphologic observation showed that “Shengjin Renzao Prescription” can inhibit lymphocyte infiltration of submandibular gland stroma in model mice.  Conclusion:“Shengjin Renzao Prescription” can improve the symptom of the SS in mice by adjusting the response function of lymphocytes.