Objective:To optimize the extraction and purification techniques of “Luhong Prescription”  Methods:Astragaloside IV, hydroxysafflor yellow A extraction rate and yield rate of dry extract as the chemical index, the amount of water, soaking time and extraction time on the extraction process were investigated by orthogonal design test. The purification process of “Luhong prescription” was determined by using single factor test  Results:Optimization of extraction process were as follows:with 8 times amount of water, soaking for 30 minute, decocting two times, each time with 30 minutes; Optimization of purification technology is high-speed centrifugation, speed is 10 000 r/min, time is 10 minutes  Conclusion:The extraction and purification process is reasonable, stable and feasible, and can provide reference basis for further research and development of “Luhong Prescription”.