Objective:To evaluate the therapeutic efficacy of “Jianpi Ruangan Decotion” (JRD) in treatment of HBV-related decompensated liver cirrhosis with Syndrome of spleen deficiency and blood stasis  Methods:Eighty-five HBV-related decompensated liver cirrhosis patients with Syndrome of spleen deficiency and blood stasis were assigned to two groups by using a random number table:“Jianpi Ruangan Decotion” treatment group (n=43),and control group treated with Fuzheng Huayu Capsule (n=42).In all cases, the treatment course was one year.Clinical efficacy, chronic liver disease questionnaire (CLDQ), Child-Pugh grade (CPT scores), liver function,HBV-DNA, liver fibrosis index, ultrasonic examination and fibroscan test were evaluated in both groups before and after treatment  Results:①The overall effective rate was 93.02% in the treatment group and 75.61% in the control group,with a difference between the two groups. ②After treatment,CLDQ,CPT scores were significant different between groups(P<0.05). ③ After treatment,the reducing of ALT, AST, TBIL, HBV-DNA and improving of ALB,CHE were significant different between groups(P<0.05).④After treatment,HA and Ⅳ-C were significant different between groups(P<0.05). ⑤After treatment,the MPV, SPV, spleen-length, spleen-thickness and CAP were significant different between groups(P<0.05)  Conclusion:“Jianpi Ruangan Decotion” has a good therapeutic effect in treatment of HBV-related decompensated liver cirrhosis with Syndrome of spleen deficiency and blood stasis with improvement of the patient’s life quality, liver function and liver fibrosis index.