Objective:To observe the clinical curative effect of “Huashen Mixture” combined with Clarityne in treating wind-heat urticaria  Methods:129 cases of wind-heat urticaria were paired randomly divided into two groups, the control group of 65 cases was treated with Clarityne, while on this basis the observation group of 64 cases was added with “Huashen Mixture”. During one month’s treatment, the clinical symptom score was evaluated and compared, including the number and diameter of wheal, the frequency and duration of wheal, the degree of itching, and the clinical curative effect also was compared between these two groups  Results:①The clinical curative effect of the observation group was 100.00%, the control group was 96.92%; the differences were significant (P<0.05). ②After treatment, the number, the diameter, the duration of wheal and the degree of itching scores were significantly lower in the observation group than in the control group (P<0.05). ③After treatment, the frequency of wheal was significantly lower in the observation group than in the control group (P<0.05)  Conclusion:Combination “Huashen Mixture” and Clarityne in treating wind-heat urticaria can significantly improve the clinical symptoms, reduce the frequency of wheal.