Objective:To optimize and establish the best decocting technology of “Compound Shihu Qingfei Powder” by method of orthogonal design  Methods:HPLC and The complete L,9,(3,3,) orthogonal design were used to optimize the decocting technology of “Compound Shihu Qingfei Powder”,including water solvents,decocting times and time；the paste-froming rate and content of hesperidin were monitored  Results:The best decocting technology was that using 10 times amount of water, soaking for 35 minutes decocting 3 times, 1 hour for each time of decocting. It was shown that the linear relationship of hesperidin was good in 66.93~334.67mg/L, and the precision test,the sample stability test and the repetitive experiment were well  Conclusion:The decocting technology of “Compound Shihu Qingfei Powder” was stable, feasible and reliable,which could provide reference for actual production.