JIANG Hong-qiang, ZHANG Jin-guo. Research progress on the protective effects of Astragalus mongholicus and derivates thereof in rat model for chronic heart failure[J]. Shanghai Journal of Traditional Chinese Medicine, 2015,49(10):90-93.
JIANG Hong-qiang, ZHANG Jin-guo. Research progress on the protective effects of Astragalus mongholicus and derivates thereof in rat model for chronic heart failure[J]. Shanghai Journal of Traditional Chinese Medicine, 2015,49(10):90-93.DOI:
This paper aims to comprehensively summarize the underlying mechanism of the biological treatment in rat model for heart failure by Astragalus mongholicus and derivates thereof. It is believed that Astragalus mongholicus and derivates thereof may treat chronic heart failure in rat model in a “multi-path and multi-target” way, and the action mechanism of which include improving heart function and energy metabolism, intervention in neuroendocrine system, inhibition calcium overloading, heart failure related cytokines and cardiac hypertrophy, decreasing oxygen-derived free radicals content and myocardial apoptosis, etc.