Objective:To observe the clinical effect of “Ningshen Mixture” treating postmenopausal women with abnormal blood lipids  Methods:70 postmen-opausal women with abnormal blood lipids were randomly divided into treatment group and control group, 35 cases in each group. The treatment group was treated with “Ningshen Mixture” while control group was given by Simvastatin. Courses of the both groups were 2 months. Levels of blood lipid and sex hormones, dietary scores and BMI were observed  Results:① 68 cases completed the test finally, which contained 34 cases of treatment group and 34 cases of control group. ② Intra-group comparison:All indexes had significant difference in both groups before and after treatment(P,<,0.05). Compared between the two groups after the treatment, there were significant differences of the levels of TC, LDL-C(P,<,0.05). ③ Compared between the two groups after the treatment, there were significant differences of the levels of E,2, and T(P,<,0.05). ④ Compared between the two groups after the treatment, there were no obvious difference for dietary scores(P,>,0.05), but there were significant differences of the levels of BMI(P,<,0.05)  Conclusion:The effect of treating postmenopausal women with abnormal blood lipids with “Ningshen Mixture” were satisfied, of which possible mechanism was to regulate sex hormones level in Vivo.