Objective:To explore the effect of “Bushen Jianpi Decoction” on tumor recurrence inhibition of high metastasis models of human hepatocellular carcinoma (HCC) after curative in nude mice and its synergies and toxicity-reducing effect on Sorafenib  Methods:Decorticate and reset the tumor in HCCLM3 model nude mice with a size of 1 mm×1 mm×1 mm. Transplant the tumor into the liver of experimental nude mice orthotopicly. On postoperative day 15,do laparotomy to resct the new tumor. Divide experimental nude mice into group A,B,C and D,6 in each group. From the 3rd day of the 2nd surgery,according to the nude mice weight,they received gavage in a dosage of 0.1ml/10 g each day,for 4 weeks in all. Group A were given “Bushen Jianpi Decoction”. Group B received Sorafenib suspension. Group C were treated with both two medicines. Group D were administered 0.9%NS. Record the weight of nude mice pre-dose,the 7th,14th,21st and 28th day(D0,7, 14,1, 28)of the course as well as the fodder consumption every day of each group. After treatment,the tumor weight and size were measured and Blood Routine Index(eg.WBC,RBC,Hb,PLT) were tested  Results:① Tumor weight and size:In Group A,B and C,Tumor weight(P<0.001) were lower and size(p=0.001) smaller than in Group D; Both weight and size in Group C decreased more than Group A(P<0.05). ② Mice weight:Compared Group A with Group B,C,D, there was statistical difference(P<0.05). Mice weight on D7、14、21、28 were all lower than D0(P<0.05).Falling range from smaller to larger was Group A(0.60±1.75),C(1.29±1.63),D(1.57±1.84)and B(2.14±2.40). ③ Fodder consumption:Compared Group A with Group B,C,D, there was statistical difference(P<0.001)；Group C and D had statistical difference(P<0.05). Group A ate more than the other groups while Group C’s fodder consumption first slowly raised then decreased. Fodder consumption of Group B and D reduced more obviously. ④ Blood Routine Index(WBC, RBC, HGB, PLT):Four indexes of Group A and D had no statistical difference(P>0.05),but WBC,RBC and HGB count of Group A were higher than D. Compared Group A with Group B and C,there were statistical difference(P<0.05). Group B was the lowest of all indexes(P<0.05). Group C was a little bit more than B,while Group B and C had no statistical difference(P>0.05)  Conclusion:“Bushen Jianpi Decoction” could inhibit recurrent tumor growth,improve the body resistance against Sorafenib,decrease its toxic reaction to the Blood System,and stablize the body dietary and weight. The Decoction could restrain HCC recurrence after hepatectomy,and it had synergies and toxicity-reducing effect on Sorafenib.