Objective:The aim of this study is to investigate the effect of “Danzhi Jiangtang Capsule” on PI3K/AKT signaling pathway in the liver of diabetic rats  Methods:55 male SD rats were fed with high calorie diet except the normal control group for 4 weeks. A single intraperitoneal injection of streptozotocin (STZ) of 35mg/kg,when the diabetic rodent model was build, the rats were randomly re-divided into 4 groups:model group, high-does group of DJC, low-does group of DJC and pioglitazone group. High-does group of DJC and low-does group of DJC were treated with 1.08 g/(kg·d) and 0.54 g/(kg·d) repectively, pioglitazone group was treated with 10mg/(kg·d), the blank group and the model group were treated with the same volume of saline .Continuous intragastric administration for 8 weeks,took the liver,detected β-actin, PI3K/AKT in liver tissue of rats by reverse transcription reaction and Quantitative Real-time PCR. Total RNA was extracted from the liver tissue of rats with Trizol kit,determinated the blood glucose and blood lipid  Results:Expression of PI3K/AKT in model group increased significantly ,DJC evidently inhibited the excessive expression of PI3K/AKT and RNA. Compared with the normal control group (P<0.05 or P<0.01); the blood glucose of rats were increased significantly (P<0.01) compared with. After being given “Danzhi Jiangtang Capsule ” for 8 weeks,the level of glucose was decreased(P<0.01) ,curative effect was similar to Pioglitazone. The blood glucose and the PI3K/AKT correlation analysis showed a significant positive correlation  Conclusion:The DJC has a significant intervention effect on the over expression of PI3K/AKT signaling pathway in the liver of diabetic rats,this may be related to the protection of the liver,reduced vascular endothelial inflammatory reaction.