Objective:To observe the clinical efficacy of modified “Shengjiang Powder” in the treatment of pulmonary infection combined with sepsis of toxin-heat excess  Methods:Fifty subjects were randomized into two groups:control group in which 25 cases were treated with routine modality and treatment group in which 25 cases were treated with routine modality and modified “Shengjiang Powder”, with a course of 7 days. The symptom scores, APACHEⅡ score, CRP, TNF-α and IL-6 were evaluated before and after treatment  Results:After treatment, the symptom scores were reduced in both groups(P<0.05), with lower score in the treatment group than in the control group(P<0.05); the APACHEⅡ scores and the levels of CRP, TNF-α and IL-6 were decreased in both groups(P<0.05), with more significant decrease in the treatment group than in the control group(P<0.05)  Conclusion:Modified “Shengjiang Powder” is effective for pulmonary infection combined with sepsis of toxin-heat excess by reduce the levels of inflammatory cytokines to depress inflammation.