Objective:To observe the clinical efficacy of combined “Zicui Juanbi Decoction” and transcutaneous acupoint electro-stimulation(TAES) in the treatment of diabetic peripheral neuropathy(DPN)  Methods:One hundred and thirty two cases of DPN were randomized into four groups(mecobalamine group, TAES group, herbal group and combined group, 33 cases in each group), and treated by respectiv  Methods: for one month. The clinical efficacy, Toronto clinical system scores(TCSS), blood glucose, ankle-brachial blood pressure index(ABI) and velocity of dorsal pedal artery were observed before and after treatment  Results:①The clinical effective rate was 48.5%, 74.2%, 78.1% and 90.6% respectively in mecobalamine group, TAES group, herbal group and combined group, with higher rates in the latter three groups than in the former group(P<0.01). ②After treatment, the TCSS were significantly lowered in the TAES group, herbal group and combined group(P<0.01); the TCSS was lower in the TAES group, herbal group and combined group than in the mecobalamine group(P<0.05, P<0.01), and with lower TCSS in the combined group than in the TAES group and herbal group(P<0.05). ③After treatment, the levels of blood glucose(FPG, 2hPG) were reduced in the TAES group, herbal group and combined group(P<0.05, P<0.01), with lower level in the combined group than in the mecobalamine group(P<0.01). ④After treatment, the velocity of dorsal pedal artery in the combined group, herbal group and combined group was increased(P<0.01), with higher velocity in these three groups than in the tomecobalamine group(P<0.05, P<0.01)  Conclusion:Combined “Zicui Juanbi Decoction” and transcutaneous acupoint electro-stimulation(TAES) is quite effective against diabetic peripheral neuropathy in relieving clinical symptoms and peripheral hemodynamics.