Objective:To observe clinical effect of “Yiqi Huayu Decoction” in the treatment of qi deficiency and blood stasis type of uterine leiomyoma  Methods:60 cases of uterine fibroids were randomly divided into treatment group and control group, 30 cases in each group. The treatment group received “Yiqi Huayu Decoction”, control group were treated with Guizhi Fuling capsule. Two groups were treated for 3 menstrual cycles, observing the size of uterine leiomyoma, menstruation (menstrual period and menstrual volume), TCM syndrome score and female hormone (FSH, LH, E,2,) levels  Results:①Compared before and after treatment within group, the two groups were statistically significant differences in the size of uterine leiomyoma (P,<,0.05); between the groups after treatment, and there has no statistically significant difference between the volume of uterine leiomyoma(P,>,0.05).②Between the groups after treatment, the efficacy of the treatment group significantly better than the control group in shorten the menstrual period and reduce menstruation(P,<,0.05). ③Compared before and after treatment within group,the two groups were statistically significant difference between the TCM syndrome score (P,<,0.05); between the groups after treatment, there was statistical significance of TCM syndrome score (P,<,0.05). ④Comparison of before and after treatment within group, the two groups had no statistically significant differences in the level of FSH, LH and E,2, (P,>,0.05); between the groups after treatment comparison,no statistically significant differences in the level of FSH, LH and E,2, (P,>,0.05)  Conclusion:“Yiqi Huayu Decoction” treating qi deficiency and blood stasis type of uterine leiomyoma, can reduce the tumor volume, improve menstrual disorders, relieve the clinical symptoms of patients.