Objective:This paper is to observe the clinical efficacy of cooling blood, clearing heat and removing dampness formula in treating damp heat immersed type of eczema  Methods:178 cases of damp heat immersed type of eczema patients randomly divided into treatment group and control group on average, the control group was treated with loratadine and the treatment group was treated with cooling blood, clearing heat and removing dampness formula, both of the treatment of course were 2 months. Clinical efficacy, itch degree and changes of TCM syndrome were observed  Results:The clinical efficacy of the treatment group and control group was 88.8% and 71.9% respectively, the clinical efficacy of treatment group was better obviously than the control group(P<0.05). After the treatment, the itch degree accumulated point and TCM symptom accumulated point of the two groups decreased obviously(P<0.05), and the accumulated points of the treatment group was lower than the control group(P<0.05)  Conclusion:Cooling blood, clearing heat and removing dampness formula has good effect in treating damp heat immersed type of eczema.