Objective:To observe the clinical efficacy of “Huosu Yangwei Syrup” in treating precancerous lesions of gastric cancer  Methods:Sixty cases with PLGC were randomized into treatment group and control group, with 30 cases in each group. The control group was treated with “Weifuchun Tablets” and the treatment group was treated with “Huosu Yangwei Syrup”, with the course of 3 months. The clinical efficacy, pathological changes of gastric mucosa and the levels of serum PG and the quality of life in both groups were observed and compared  Results:①The total effective rate was 86.67% and 66.67% in the treatment group and control group respectively, with a difference between the two groups(P<0.05). ② There were significant differences in the levels of PGⅠ and PGⅠ/PGⅡ in the treatment group between before and after treatment (P<0.05); and significant difference was found in the PGⅠ/PGⅡlevels of the control group after treatment (P<0.05); After treatment, there were significant differences in the levels of PGⅠ and PGⅠ/PGⅡ between the two groups (P<0.05). ③In both groups, there were significant differences in gastric atrophy and intestinal metaplasia between before and after treatment (P<0.05); After treatment, no significant difference was found in atrophy and intestinal metaplasia between the two groups (P<0.05). ④ In both groups, there were significant differences in PRO scores and total scores between before and after treatment (P<0.05); After treatment, there were significant differences in the scores of spleen and stomach system, social psychological symptom and total score between the two groups (P<0.05)  Conclusion:“Huosu Yangwei Syrup” is effective to reverse the trend of gastric precancerous lesions, relieve clinical symptoms, improve the quality of life in treating precancerous lesions of gastric cancer.