中医治疗慢性肾衰竭用药规律探析

林丰夏; 雷彩云; 丁陈陈; 施利; 张四方

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中医治疗慢性肾衰竭用药规律探析

学科新探 | 更新时间：2022-08-31

- 中医治疗慢性肾衰竭用药规律探析
- Analysis on the principles of Chinese medicine for the treatment of chronic renal failure
- 上海中医药杂志 2015年49卷第5期页码：8-11
- 作者机构：
  
  1. 中南大学湘雅二医院中西医结合科,湖南,长沙,410006
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目(81273722);湖南省卫生厅科研资助项目(201135)
- DOI：
  中图分类号：
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林丰夏, 雷彩云, 丁陈陈, 等. 中医治疗慢性肾衰竭用药规律探析[J]. 上海中医药杂志, 2015,49(5):8-11.

LIN Feng-xia, LEI Cai-yun, DING Chen-chen, et al. Analysis on the principles of Chinese medicine for the treatment of chronic renal failure[J]. Shanghai Journal of Traditional Chinese Medicine, 2015,49(5):8-11.
林丰夏, 雷彩云, 丁陈陈, 等. 中医治疗慢性肾衰竭用药规律探析[J]. 上海中医药杂志, 2015,49(5):8-11. DOI：

LIN Feng-xia, LEI Cai-yun, DING Chen-chen, et al. Analysis on the principles of Chinese medicine for the treatment of chronic renal failure[J]. Shanghai Journal of Traditional Chinese Medicine, 2015,49(5):8-11. DOI：

摘要

目的：基于文献分析,探讨中医治疗慢性肾衰竭的用药规律方法：通过数据库检索2004-2014年发表的有关中药治疗慢性肾衰竭的临床研究文献,运用频数分析、因子分析、聚类分析等方法分析相关方剂的药物组成、功能分类、治法等情况,进而探讨其中的用药规律结果：①共纳入73篇文献,收集中药方剂73首,涉及药物131味,药物总频次784次。②因子分析及频数分析发现,最能体现本病证治特点的15味药物为大黄、黄芪、丹参、茯苓、白术、当归、淫羊藿、川芎、党参、半夏、土茯苓、山茱萸、枸杞、牛膝、杜仲。③治法频数统计发现,益气健脾、通腑降浊、活血化瘀、补益肝肾法应用最为广泛。④聚类分析发现有意义的两组药物组合,分别为大黄、黄芪、丹参(C1),当归、茯苓、白术(C2) 结论：慢性肾衰竭临床常从虚、浊、瘀论治,治法以通腑降浊、扶正补益、活血化瘀、化湿解毒等为主,常用药物如大黄、黄芪、丹参、茯苓、白术等。

Abstract

Objective:To analyze the principles of Chinese medicine for the treatment of chronic renal failure (CRF) based on literature analysis Methods:Search and screen out the articles published through the database from 2004 to 2014 on Chinese medicine for the treatment of CRF with Chinese medicine. We analyzed the composition, function category and therapeuti Methods: of the medicine by frequency analysis, factor analysis and cluster analysis to discuss the medication law Results:①Seventy-three articles were involved in the research, collecting 73 prescriptions and 131 kinds of herbs and 784 times of total medicine frequency. ②Through factor analysis and frequency analysis, the herbs which can mostly reflect the treating principles are the 15 kinds:Dahuang (Radix et Rhizoma Rhei), Huangqi (Radix Astragali seu Hedysari), Danshen(Radix Salviae Miltiorrhizae), Fuling(Poria), Baizhu(Rhizoma Atractylodis Macrocephalae), Danggui(Radix Angelicae Sinensis), Xianlingpi(Herba Epimedii), Chuangxiong(Rhizoma Ligustici Chuanxiong), Dangshen(Radix Codonopsis), Banxia(Rhizoma Pinelliae), Tufuling(Poria), Shanzhuyu(Fructus Corni), Gouqi(Fructus Lycii), Niuxi(Radix Achyranthis Bidentatae), Duzhong(Cortex Eucommiae). ③Treatment frequency shows that measures like purging fu-organs and Turbid-Expelling, nourishing qi to invigorate spleen, activating blood and tonify the liver and kidney are the most widely used. ④Cluster analysis reveals two significant herb combinations:C1[Dahuang(Radix et Rhizoma Rhei), Huangqi(Radix Astragali seu Hedysari), Danshen(Radix Salviae Miltiorrhizae)] and C2[Fuling(Poria), Baizhu(Rhizoma Atractylodis Macrocephalae), Danggui(Radix Angelicae Sinensis)] Conclusion:Treating CRF with Chinese medicine can focus on the “weakness” “turbid” and “stasis”, so the main therapies are tonifying deficiency, purging fu-organs and expelling turbid, activating blood, dissipating dampness and poison. The most frequently used medicines are Dahuang(Radix et Rhizoma Rhei), Huangqi(Radix Astragali seu Hedysari), Danshen(Radix Salviae Miltiorrhizae), Fuling(Poria), Baizhu(Rhizoma Atractylodis Macrocephalae), etc.

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慢性肾衰竭中医药疗法用药规律文献研究

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