Objective:To observe the therapeutic effect of “Guizhi Fuling Pills” in treating dysmenorrheal models  Methods:Take the method of intravenous of oxytocin to rats, to observe the effect of “Guizhi Fuling Pills” on rats’ uterine smooth muscle in vivo; the rat models of dysmenorrhea were established by intraperitoneal injection of oxytocin, to observe the effect of “Guizhi Fuling Pills” on dysmenorrhea modeld; by using capillary glass tube method, we observed the influence of “Guizhi Fuling Pills” on blood clotting time in mice; acute blood stasis rat models were established by the method of ice water bath and intraperitoneal injection of epinephrine. Observed the hemorheological effects of “Guizhi Fuling Pills” and the anti-inflammatory action of “Guizhi Fuling Pills” on mice ear swelling induced by xylene  Results:Compared with the model group, uterine smooth muscle contraction in vivo of each dose group treated with “Guizhi Fuling Pills” were decreased obviously (P<0.05); number of mice body torsion reaction occurred within 15 min were obviously decreased (P<0.05) and blood clotting time in mice were significantly prolonged (P<0.05); the blood viscosity, plasma viscosity, erythrocyte sedimentation rate (ESR) and erythrocyte electrophoresis time (EET) were reduced significantly (P<0.05), and the prothrombin time was prolonged (P<0.05); mice ear swelling in high, middle dose group treated with “Guizhi Fuling Pills” was significantly reduced (P<0.05)  Conclusion:“Guizhi Fuling Pills” has obvious effects on inhibition of excessive contraction of rats uterine smooth muscle in vivo, analgesia, anticoagulation and anti-inflammation, and have good therapeutic effects on dysmenorrhea.