Objective:To study the relation between the syndrome of TCM of community-acquired pneumonia (CAP) combined sepsis with CRP, PCT, D-Di and to analyze the regularities of distribution of indexes among the syndrome of TCM  Methods:One hundred and eighty-six CAP patients combined with sepsis were selected to investigate distribution of TCM syndrome, and the levels of CRP, PCT and D-Di were detected  Results:① In the compare of constituent ratio of syndrome of TCM, the syndrome of toxic heat flourishing (22.58%), heat the ying blood (27.96%), stasis poison resistance (26.89%) is common. ② The CRP level in evil poison attack the lung group is lower than other groups (P<0.01), and there is no statistically significant difference among the syndrome of toxic heat flourishing, heat the ying blood, stasis poison resistance groups. The PCT of deficiency of both qi and yin group and toxic heat flourishing group is higher than evil poison attack the lung group (P<0.01) and is lower than heat the ying blood, stasis poison resistance groups (P<0.01). The D-Di of heat the ying blood, stasis poison resistance groups is higher than other groups significantly (P<0.01), and the stasis poison resistance group is highest. It is statistically significant difference compared with heat the ying blood group (P<0.01)  Conclusion:Combined detection of PCT,D-Di for syndrome differentiation of TCM of CAP with sepsis patients has a certain reference value.