Objective: To observe the clinical efficacy of minimally invasive thread-embedding at acupoints combined with western medicine in treating moderate to severe chronic obstructive pulmonary disease (COPD) in stable phase. Methods Two hundred patients with moderate to severe COPD in stable phase were randomly divided into the treatment group and control group, with 100 cases in each group. The control group was treated with conventional western medicine, and the treatment group was treated with minimally invasive thread-embedding at acupoints additionally, with the course of one year. The times of acute exacerbation of COPD (AECOPD), severe exacerbations, SGRQ score, Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), 6 minutes walking distance (6MWD), and lung function (FEV,1, FEV,1,/FVC), as well as the safety indexes were observed.  Results: ① One hundred and eighty-five patients were followed up for 1-year, 7 patients were lost in the treatment group, while 8 patients were lost in the control group. ②After treatment, there were significant differences in AECOPD, number of severe exacerbations, SGRQ score, HAMA, HAMD, and 6MWD between the two groups (P＜0.05). ③ After treatment, no significant difference was found in the levels of FEV,1, and FEV,1,/FVC between the two groups (P＞0.05). ④ No significant difference was found in adverse reaction rate between the two groups (P＞0.05).  Conclusion: Combined minimally invasive thread-embedding at acupoints and western medicine is effective to reduce the number of AECOPD, and improve the clinical symptoms, activity endurance, and relieve depression and anxiety in patients with moderate to severe COPD in stable phase.