Objective: To observe the clinical efficacy of ascites cataplasm and western medicine for the treatment of ascites due to liver cirrhosis of the spleen and kidney yang deficiency pattern  Methods: One hundred and eight cases with ascites due to liver cirrhosis of the spleen and kidney yang deficiency pattern were randomized into treatment group and control group, with 54 cases in each group. Treatment group was treated with ascites cataplasm and western medicine, and control group was treated with placebo cataplasm and western medicine, with the course of 14 days. The clinical efficacy, occurrence rate of adverse reactions were observed in both groups, and the TCM symptom scores and changes of clinical signs were compared between the groups  Results: ① All the 107 cases were finished the trial, 54 in the treatment group and 53 in the control group. ② The total effective rate was 79.63% in the treatment group and 66.04% in the control group, with a difference between the two groups (P<0.05). ③ After treatment, there were significant difference in the TCM symptoms scores in each group (P＜0.05); with significant difference between the two groups, and treatment group was superior to the control group (P＜0.05). ④ In both groups, there were significant differences in the 24 h urine volume, abdominal circumference and body mass index between before and after treatment (P＜0.05); after treatment, there were significant differences in the above indexes between the two groups, and the treatment group was superior to the control group (P＜0.05). ⑤ No significant difference was found in occurrence rate of adverse reactions in both groups (P>0.05)  Conclusion: Combined ascites cataplasm and western medicine has positive effect on ascites due to liver cirrhosis of spleen and kidney yang deficiency pattern by improving its clinical symptoms and signs.