Objective:To observe the clinical efficacy of “Lianfu Weihe Oral Solution” (LFWH) and triple therapy for the treatment of helicobacter pylori infection  Methods: One hundred and eighty cases with helicobacter pylori infection were randomized into treatment A group, treatment B group, and control C group, with 60 cases in each group. Group C was treated with triple therapy (Omeprazole, amoxicillin and clarithromycin); group A was treated with normal dose of LFWH and triple therapy; group B was treated with high dose of LFWH and triple therapy, with the course of 7 days. The Hp eradication rate, clinical efficacy and adverse reactions were observed  Results: ① Finally 172 cases fulfilled the trial, fifty-nine cases in group A, 57 in group B and 56 in group C. ② Full analysis set (FAS) showed that the Hp eradication rates of group A, B and C were 80%, 80.7% and 71.7% respectively; no significant difference was found among the groups (P＞0.05). Meanwhile, Protocol analysis set (PPS) showed that the Hp eradication rates of group A, B and C were 81.36%, 80.70% and 76.79% respectively; no significant difference was found among them (P＞0.05). ③ Full analysis set (FAS) showed that the clinical efficacy of the group A, B and C were 91.67%, 91.23% and 70.00% respectively; no significant difference was found among them (P＜0.05), but with significant difference between group A and C, and between group B and C (P＜0.05). PPS showed that the clinical efficiency of group A, B and C were 93.22%, 91.23% and 75.00% respectively; with significant difference among them (P＜0.05), as well as between group A and C, and between group B and C (P＜0.05). ④ Total of 21 cases of adverse reactions appeared in the trial, with 3 cases in the group A, 6 cases in the group B and 12 cases in the group C; with significant difference in occurrence rate of adverse reactions among them (P＜0.05), as well as between any two groups (P＜0.05)  Conclusion: Combined LFWH and triple therapy can achieve satisfaction effects on the treatment of helicobacter pylori infection, and less adverse reactions. But high dose of “Lianfu Weihe Oral Solution” does not recommend.