Objective: To observe the TCM syndrome distribution and clinical characteristics of late onset hypogonadism  Methods: Four hundred and sixty-one cases with late onset hypogonadism (LOH) were divided into TCM syndrome types. The scales of AMS were surveyed and the total testosterone (TT) levels in serum were detected  Results: Among the 461 patients, the deficiency of liver yin and kidney yin (34.49%) were the main two TCM syndrome types of LOH. The rest of them are deficiency of kidney yang type, kidney deficiency and liver depression type, deficiency of heart and spleen type, etc. Symptom scores of angiokinesis in deficiency of liver yin and kidney yin type was higher than those of the other types, while symptom scores of physical ability was lower than those of the other types (P＜0.05); scores of sexual function in deficiency of kidney yang type was higher than those of the other types, but the symptom scores of angiokinesis was lower than those of the other types (P＜0.05); symptom scores of mental-psychological in kidney deficiency and liver depression type was higher that those of the other types(P＜0.05). The testosterone (TT) levels in serum of the deficiency of kidney yang type and deficiency of heart and spleen type were lower than those of the deficiency of liver yin and kidney yin type and kidney deficiency and liver depression type (P＜0.05)  Conclusion: The deficiency of liver yin and kidney yin and deficiency of kidney yang type are the main types of LOH. There are significant differences in clinical efficacy and TT level among TCM syndrome types.