Objective: To observe the clinical efficacy of “He's Xinfang Jindan Decoction” in treating fatty liver  Methods: Eighty cases with fatty liver of the dampness-heat of liver and gallbladder pattern were treated with “He's Xinfang Jindan Decoction”, with the course of 12 weeks. The clinical efficacy was observed after treatment, and was followed-up for 12 weeks after drug withdrawal  Results: The total effective rate was 93.75% after treatment and was 86.25% in follow-up  Conclusion: “He's Xinfang Jindan Decoction” has positive effects on fatty liver of dampness-heat of liver and gallbladder pattern, either in short-term or long-term.