Objective:To observe the clinical efficacy of “Gegen Huzhang Decoction” in treating ventricular premature beat (VPB).MethodsOne hundred cases with VPB were randomized into treatment group and control group, with 50 cases in each group.Control group was treated with Mexiletine Hydrochloride Tabltes orally, and treatment group was treated with “Gegen Huzhang Decoction” orally, with the course of 4 weeks.The clinical efficacy and frequency of VPB were observed in both groups.ResultsThe total effective rate was 90.0% in the treatment group and 74.0% in the control group, with a difference in clinical efficacy between the two groups(P<0.05).After treatment, the frequency of VPB was decreased in both two groups (P<0.05, P<0.01), and the frequency of VPB in the treatment group was less than that of the control group (P<0.05).Conclusion“Gegen Huzhang Decoction” has positive effect on VPB.