Objective: To observe the clinical efficacy of “Ertong Huichun Granules” in treating herpangina in children.Methods One hundred and thirty-two children with herpangina were randomized into treatment group and control group, with 66 cases in each group.Both groups were treated with conventional therapy, and treatment group was added with “Ertong Huichun Granules”, with the course of 7 days.Results The overall effective rate was 95.5% in the treatment group and 75.8% in the control group, with a difference between the two groups (P<0.05), the clinical efficacy in the treatment group was superior to the control group.The fever time, salivation disappearance time, simplex regression time in the treatment group were less than those of the control group (P<0.05).Conclusion “Ertong Huichun Granules” is effective to improve the clinical efficacy and shorten the course of herpangina.