Objective: To observe the clinical efficacy of “Compound Danfu Ointment” and fumigating-steaming therapy in treating chilblain at Great heat.Methods At the day of Great heat, cases in the treatment group were treated with the combination of “Compound Danfu Ointment” and fumigating-steaming therapy, and cases in the control group were treated with Vaseline and fumigating-steaming therapy, with the course of 10 days.The clinical efficacy, scores of skin lesion and subjective symptoms were observed before and after treatment.Results The total effective rate was 71.93% in the treatment group and 36.67% in the control group, with a difference between the two groups (P<0.05).After treatment, the scores of skin lesion were reduced in the treatment group (P<0.01), and scores of skin lesion in the treatment group were lower than that of the control group (P<0.05); the subjective symptom scores were reduced in the treatment group (P<0.01), and were lower than that of the control group (P<0.05).Conclusion Combined “Compound Danfu Ointment” and fumigating-steaming therapy can prevent or alleviate the chilblain at Great heat.