Objective: To observe the effect of Radix Ginseng and Radix Aconiti Lateralis Preparata on hemorheology and cognitive ability in rats with myocardial ischemia of the blood stasis pattern.Methods Sixty SD rats were randomly divided into six groups:blank control group, model group, intraperitoneal “Shenfu Injection” group, oral “Shenfu Injection” group, high dose of “Shenfu Decoction” group, low dose of “Shenfu Decoction” group, with 10 rats in each group.Except for blank group, the rat models with myocardial ischemia were established.Each group was treated with corresponding measurements.The viscosity, blood cell parameters (MCV, RDW-CV, MPV and PDW) and hemorheologic indicators were observed.The cognitive ability in each group was detected.Results ① Compared with the blank group, there were significant differences in the ECG,blood cell parameters, blood viscosity in the model group (P<0.05), which indicated that the blood stasis models were established successfully.② Compared with the model group, the ST amplitude, low, medium and high shearing rates, value of MCV, RDW-CV and MPV and error of step-down test were decreased significantly (P<0.05); the PDW value and blood viscosity in injection group and administration group were decreased (P<0.05); the latent time in the in injection group, administration group and high dose group were increased (P<0.05).there were significant differences in the ST amplitude, blood viscosity, blood cell parameters (MCV, RDW-CV, MPV), sedimentation rate and error of step-down test between the injection group and low dose of “Shenfu Decoction” group (P<0.05).No statistical significance was found in all indicators of the “Shenfu Injection” groups (P>0.05), which indicated that the clinical efficacy of the two groups were similar.③ Correlation analysis on the resultes of the hemorheology and behavior indicators showed that there was correlation between hemorheology and cognitive competence.Conclusion Combination of Radix Ginseng and Radix Aconiti Lateralis Preparata can improve the cognitive competence by improving the property of hemorheology.