最新刊期
期 5 ， 2023
- 摘要：Based on the “Chapter 6： Blood Impediment and Deficiency Exhaustion—Pulses， Patterns and Treatment” in the traditional Chinese medicine （TCM） classic Synopsis of Golden Chamber， the TCM pathogenesis and development， as well as treatment scheme of “strengthening vital qi and resolving blood stasis” of liver cirrhosis was discussed on the basis of “long-term blood impediment and accumulation of deficiency exhaustion”. At present， TCM diagnosis and treatment for liver cirrhosis is based on the pathogenesis of “amassment and accumulation” and “tympanites” and the treatment method of activating blood and resolving stasis， but the theoretical summary of clinical diagnosis and treatment is still lacking. We elaborate the TCM theory of “blood impediment leads to exhaustion， and liver exhaustion generates accumulation”， proposing that “long-term blood impediment and accumulation of deficiency exhaustion” is the basic TCM pathogenesis of liver cirrhosis， and “long-term blood impediment and intermingled stasis and heat” is the TCM pathogenesis of jaundice in liver cirrhosis. The “Blood Impediment and Deficiency Exhaustion Chapter” in Synopsis of Golden Chamber has enlightened the TCM phased treatment of liver cirrhosis in the clinic.关键词：liver cirrhosis;jaundice;cirrhotic ascites;Synopsis of Golden Chamber;blood impediment;deficiency exhaustion;traditional Chinese medicine therapy
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发布时间：2023-05-16 - 摘要：Hepatic encephalopathy is a disorder of the central nervous system caused by severe liver dysfunction， abnormal portal venous circulation and metabolic abnormalities. It often manifests with different degrees of neuropsychiatric abnormalities， and belongs to the categories of “tympanites”， “abdominal mass”， “jaundice” and “unconsciousness” in traditional Chinese medicine. The main indication of Taohe Chengqi Decoction is abdominal pain with madness. Therefore， it is often used clinically to treat hepatic encephalopathy with good therapeutic results. The mechanism of Taohe Chengqi Decoction in the treatment of hepatic encephalopathy is discussed from the perspective of “the liver connecting with Yangming”.关键词：hepatic encephalopathy;Taohe Chengqi Decoction;liver connecting with Yangming;classic formula;gut-liver axis;traditional Chinese medicine therapy
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发布时间：2023-05-16 - 摘要：This paper aims to summarize Professor Wang Lingtai’s experience in differentiating and treating chronic liver diseases based on the theory of “Danggui （Angelicae Sinensis Radix） activating blood and Danshen （Salviae Miltiorrhizae Radix et Rhizoma） harmonizing blood”. It is believed that the onset of chronic liver diseases starts with qi stagnation， gradually affects the blood， and eventually leads to stagnation of qi and blood. When it comes to the treatment of chronic liver diseases， it is necessary to strengthen the healthy qi and eliminate pathogenic factors， regulate the movement of qi and focus on the treatment of stasis. The choice of herbs for activating blood and resolving stasis should be made depending on the comprehensive consideration of disease condition and syndrome differentiation. It is appropriate to flexibly use Angelicae Sinensis Radix to activate blood and Salviae Miltiorrhizae Radix et Rhizoma to harmonize blood. It is also highlighted that individualized treatment is the key to treat chronic liver diseases .关键词：chronic liver disease;Danggui（Angelicae Sinensis Radix）;Danshen（Salviae Miltiorrhizae Radix et Rhizoma）;activating blood and resolving stasis;famous doctor’s experience;traditional Chinese medicine therapy
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发布时间：2023-05-16 - 摘要：ObjectiveTo explore the potential mechanism of berberine in the treatment of nonalcoholic steatohepatitis（NASH） based on network pharmacology， molecular docking and in vitro cell experiments， and to provide a theoretical basis for clinical application.MethodsCharacteristic information of absorption， distribution， metabolism， and excretion of berberine was obtained from the Traditional Chinese Medicine System Pharmacology Database （TCMSP）. The potential target genes of berberine and NASH-related genes were obtained from Comparative Toxicogenomics Database （CTD） and the GeneCards human gene database （GeneCards）. The gene intersections were obtained with the Bioinformatics tool. Cytoscape v3.6.1 was used to construct a “safranin-target gene-pathway” network， and gene-gene interaction network analysis and functional enrichment analysis were performed to identify the key genes of berberine for NASH treatment. Molecular docking technology was used to evaluate the binding ability of berberine to key gene targets via webina. Normal hepatocytes （AML12） of mice at logarithmic growth stage were divided into blank group， model group and each dose group of berberine， and each group was given the corresponding intervention. The relevant target genes were verified by RT-qPCR assay.ResultsThe network analysis showed that the key genes of berberine for NASH treatment were interleukin-10 （IL-10）， prostaglandin endoperoxide synthase 2 （PTGS2）， heme oxygenase 1 （HMOX1）， CC chemokine ligand 2 （CCL2）， recombinant human interleukin 8 （CXCL8）， Toll-like receptor 4 （TLR4）， Jun proto-oncogene （JUN）， matrix metalloproteinase 9 （MMP9）， tumor necrosis factor （TNF） and interleukin-6 （IL-6）. The molecular docking results showed that berberine had good binding properties with TLR4， CCL2， MMP9 and CXCL8 proteins. The results of in vitro cell experiments showed that PTGS2， CCL2 and TLR4 mRNA were highly expressed in the model （P<0.01）； and PTGS2， CCL2 and TLR4 mRNA were lowly expressed in each dose group （P<0.01）， showing a dose-dependent trend.ConclusionBerberine can exert systemic pharmacological effects by regulating a network of key molecules in the occurrence and development of NASH.关键词：non-alcoholic steatohepatitis;berberine;network pharmacology;molecular docking;cell experiments;traditional Chinese herbal medicine
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发布时间：2023-05-16 - 摘要：ObjectiveTo investigate the mechanism of Gantangyi Recipe in ameliorating oxidative stress and regulating （GSK-3β/FoxO1） glycogen synthesis signaling pathway to regulate glucose metabolism.MethodsThe hepatocytes were incubated with 500 μmol/L H2O2 for 30 min and then divided into the model group， Gantangyi Recipe group， and metformin group. Gantangyi Recipe group and metformin group were respectively incubated with Gantangyi Recipe （200 μg/L） or metformin （5 mmol/L） for 48 h. The normal group was set up. The cell viability was detected by the CCK-8 method； supernatant glutathione aminotransferase （ALT）， glutathione aminotransferase （AST） activity， and malondialdehyde （MDA） content were detected by enzyme-linked immunosorbent assay （ELISA）； reactive oxygen species （ROS） levels were detected by DCFH-DA fluorescent probe method； glycogen content was stained by PAS staining method； cell supernatant glucose concentration in hepatocytes was detected by glucose oxidation enzyme method； and cell p-GSK-3β/GSK-3β and p-FoxO1/FoxO1 protein expressions were analyzed by Western blot.ResultsCompared with the condition of normal group， H2O2 could induce cell peroxidative damage model， the ALT， AST activity， and MDA content were significantly higher in the model group （P<0.05）， ROS generation rate was significantly higher （P<0.05）， there was a significant increase in supernatant glucose content （P<0.05）， the glycogen staining results showed significant reduction and lighter coloration of cell positive staining granules， and p-GSK-3β/GSK-3β and p-FoxO1/FoxO1 protein expressions were significantly reduced （P<0.05）. Compared with the condition of model group， the levels of ALT， AST and MDA were reduced to different degrees after the intervention of Gantangyi Recipe and metformin， the rate of ROS production was significantly reduced （P<0.05）， and the effect of Gantangyi Recipe was superior to that of metformin （P<0.05）. In the Gantangyi Recipe group， cells stained darker in glycogen staining than those in the model group， the supernatant glucose concentration decreased significantly （P<0.05）， and the p-GSK-3β/GSK-3β and p-FoxO1/FoxO1 protein expressions increased （P<0.05）.ConclusionGantangyi Recipe can alleviate the oxidative stress injury and abnormal glucose metabolism in hepatocytes induced by H2O2， and the mechanism is related to the activation of the GSK-3β/FoxO1 glycogen synthesis signaling pathway.关键词：cirrhosis;diabetes mellitus;Gantangyi Recipe;abnormal glucose metabolism;oxidative stress;glycogen synthesis;traditional Chinese herbal medicine research
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发布时间：2023-05-16 - 摘要：ObjectiveTo analyze the clinical classification of patients with drug-induced liver injury （DILI） and its correlation with TCM constitution.MethodsGeneral data （age， gender， and history of allergy， etc.）， laboratory indicators， drug information causing liver injury and TCM constitutions of patients with DILI were collected through hospital inpatient medical record system. Clinical classification （hepatocellular injury type， cholestasis type， and mixed type） was conducted according to R value. TCM constitution （normal type， qi-deficiency type， qi-stagnation type， yang-deficiency type， yin-deficiency type， damp-heat type， phlegm-damp type， blood stasis type， and special endowment type） was classified according to relevant criteria and the results of the questionnaire （telephone follow-up）. Logistic regression analysis was used to analyze the correlation between clinical classification and TCM constitution in DILI cases.Results①A total of 69 DILI cases were included in this study， and 76.8% were female with an average age of （51.06±12.19） years， while the average age of men was （45.88±12.51） years. There were 11 cases with a history of allergy. ②There were 29 cases of hepatocellular injury type， 23 cases of cholestasis type， and 17 cases of mixed type. ③Most DILI was caused by traditional Chinese herbal medicines （TCHMs） and preparations ［mostly containing Polygoni Multiflori Radix （61.9%） and Tripterygium wilfordii （28.6%）］， antipyretic and analgesic drugs， and health care products （30.4%， 15.9%， and 13.0%， respectively）. ④The majority constitution types of 69 patients were normal type， qi-deficiency type， special endowment type and qi-stagnation type （39.1%， 15.9%、14.5% and 13.0%， respectively）. ⑤The special endowment type was correlated with the clinical classification of hepatocellular injury type （P<0.05） and the cholestasis type （P<0.05）， and was a relevant factor influencing the cholestasis type of DILI ［OR=6.271，95%CI（1.443，27.253）］.ConclusionsDILI patients of the special endowment type are more likely to have cholestasis. Clinical treatment should be more cautious in selecting prescriptions and medications for patients of the special endowment type. Once DILI occurs， active treatment should be given to remove cholestasis and inhibit immunoinflammtory storm to prevent rapid progression of the disease in addition to timely withdrawal of drugs.关键词：drug-induced liver injury （DILI）;clinical classification;traditional Chinese herbal medicine;TCM constitution;correlation analysis
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发布时间：2023-05-16 - 摘要：Traditional Chinese medicine （TCM） embodies and reflects the basic connotation of precision medicine in the process of disease diagnosis and treatment. The basic ideas of TCM and the concept of precision medicine are highly compatible in many aspects， such as the “three-factor concerned treatment”， “syndrome differentiation-based treatment” and TCM quantitative diagnosis of patients’ symptoms， all reflecting the “precision concept”. The integration of TCM and modern science and technology has made the precision and personalization of TCM diagnosis and treatment system possible， which facilitates the development of TCM towards precision medicine. The precision of traditional Chinese herbal medicines （TCHMs） in terms of origin， preparation specifications， application forms， medicinal properties， efficacy and clinical applications can also contribute to the precise use of TCHMs’ therapeutic effects. This paper explains the relationship between precision medicine and TCM， the characteristics of “precision TCHMs” and the representative clinical applications of “precision TCHMs” under the premise of big health for the purpose of providing ideas for the innovative development of “precision TCHMs”.关键词：precision medicine;precision traditional Chinese herbal medicines;tumor;diabetes;cardiovascular disease;big health;preventive treatment of disease
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发布时间：2023-05-16 - 摘要：ObjectiveTo investigate the effect and mechanism of Zuojin Wan （ZJW） on reversing the resistance to cetuximab （CET） in KRAS mutation colorectal cancer.Methods①KRAS mutant human colon cancer cells HCT116 were cultured and the non-toxic dose （10 mg·L-1） of ZJW was determined by cell proliferation rate （CCK-8 assay）. The synergistic effect of ZJW and CET was observed （Due to the synergistic effect between ZJW 10 mg·L-1 and CET 100 and 200 mg·L-1， CET 100 mg·L-1 was selected for follow-up experiment in this study）. HCT116 cells in logarithmic growth phase were divided into control group， CET 100 mg·L-1 （CET group）， ZJW 10 mg·L-1 （ZJW group）， CET 100 mg·L-1+ ZJW 10 mg·L-1 （ZJW+CET group）， and were treated for 48 h. The cell cycle and apoptosis were analyzed by flow cytometry， and the expressions of nuclear factor-κB p65 （NF-κB p65） and B lymphocytoma-2 （Bcl-2） were detected by Western blot. The expressions of NF-κB p65， phosphorylated nuclear factor-κB p65（p-NF-κB p65） and cysteine aspartic protease-3 （Caspase-3） were detected by immunofluorescence， and the mRNA expressions of NF-κB p65， Bcl-2 and Caspase-3 were detected by real-time fluorescence quantitative reverse transcription polymerase chain reaction （RT-qPCR）. ②HCT116 cells were injected subcutaneously into the axilla of nude mice to establish a subcutaneously transplanted tumor model of colorectal cancer， and then 16 nude mice were randomly divided into control group （PBS gavage， n=4）， CET group （CET caudal vein injection， 15 mg·kg-1， n=4）， ZJW+CET group （CET caudal vein injection， 15 mg·kg-1； ZJW gavage， 2 055 mg·kg-1， n=4）， and ZJW group （ZJW gavage， 2 055 mg·kg-1， n=4）. Intervention were given continuously for 28 d， and tumor growth curves were plotted. The tumor tissue was stripped after 28 d， and the mRNA expressions of NF-κB p65， Bcl-2， Caspase-3 in subcutaneous transplanted tumor tissues were detected by RT-qPCR.Results①The IC10 value of ZJW in HCT116 cells was 10.71 mg·L-1； The IC50 value of CET inhibiting the proliferation of HCT116 was 578.6 mg·L-1， and the IC50 value decreased to 231.3 mg·L-1 with the combined use of 10 mg·L-1 ZJW. The drug combination index （CI） value was less than 1 when CET 100 and 200 mg·L-1 was used together with ZJW 5 and 10 mg·L-1. ②Compared with those in control group， the S-phase proportion and early apoptosis rate of cells in ZJW and ZJW+CET groups increased （P<0.05）. Compared with those in CET group， S-phase proportion and early apoptosis rate of cells in ZJW group increased （P<0.05）. Compared with those in ZJW group， S-phase cell proportion and early apoptosis rate in ZJW+CET group increased （P<0.05）. ③Compared with those in control group， the expression of Bcl-2 in CET and ZJW groups decreased （P<0.05）， the expression of Caspase-3 in ZJW group increased （P<0.05）， and the expressions of Bcl-2， NF-κB p65 and p-NF-κB p65 in ZJW+CET group decreased （P<0.05）. Compared with those in CET group， the expressions of Bcl-2， NF-κB p65 and p-NF-κB p65 in ZJW+CET group decreased （P<0.05）， while the expression of Caspase-3 increased （P<0.05）. Compared with those in ZJW group， the expressions of Bcl-2， NF-κB p65 and p-NF-κB p65 in ZJW+CET group decreased （P<0.05）， while the expression of Caspase-3 increased （P<0.05）. ④ Compared with those in control group， the mRNA expressions of Bcl-2 and NF-κB p65 in ZJW and ZJW+CET groups decreased （P<0.05）. Compared with those in CET group， the mRNA expressions of Bcl-2 and NF-κB p65 in ZJW and ZJW+CET groups decreased （P<0.05）. Compared with those in ZJW group， mRNA expressions of Bcl-2 and NF-κB p65 in ZJW+CET group decreased （P<0.05）. ⑤The tumor growth of nude mice in CET gtroup， ZJW group and ZJW+CET group was slower than that in control group. The tumors were stripped after 28 d of administration， and the volume of subcutaneous transplanted tumors in nude mice in ZJW group and ZJW+CET group was smaller than that in control group （P<0.05）. The volume of subcutaneous transplanted tumors in nude mice in ZJW and ZJW+CET groups was smaller than that in CET group （P<0.05）. The volume of subcutaneous transplanted tumors in nude mice in ZJW+CET group was smaller than that in ZJW group （P<0.05）. ⑥Compared with those in control group， the mRNA expressions of NF-κB p65 and Bcl-2 were lower and the mRNA expression of Caspase-3 was higher than that in CET Group in ZJW and ZJW+CET groups （P<0.05）. The mRNA expression of Caspase-3 in ZJW group was higher （P<0.05）. Compared with that in ZJW group， the mRNA expression of Caspase-3 in tumor tissues in ZJW+CET group was higher than that in ZJW group（P<0.05）.ConclusionsZJW can reverse the resistance to CET in KRAS mutant colorectal cancer by inhibiting cell proliferation， blocking cell cycle and promoting cell apoptosis， and subsequently inhibiting the growth of colorectal cancer. The mechanism may be related to the regulation of NF-κB/Bcl-2/Caspase-3 pathway.关键词：colorectal cancer;Zuojin Wan;targeted therapy;drug resistance;traditional Chinese herbal medicine research;mechanism of action
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发布时间：2023-05-16 - 摘要：Zhang Zhongjing， a famous doctor， made good use of the stasis-purging method to treat diseases caused by blood stasis. Therefore， his 10 formulas for purging stasis were classified into mild purgation and drastic purgation and were analyzed in this article. Wenjing Decoction， Guizhi Fuling Pill， and Dahuang Zhechong Pill were classified into mild purgation formulas， and Xiayuxue Decoction， Taohe Chengqi Decoction， Didang Decoction， Didang Pill，Dahuang Gansui Decoction， Dahuang Mudan Decoction， and Biejiajian Pill were classified into drastic purgation formulas. We summarized the formulation characteristics and clinical application indications of the two categories of formulas， insisting that formulas that could discharge blood stasis from the lower part of the body could be categorized as stasis-purging formulas. We proposed that both blood and qi should be treated， that both blood stasis and concurrent pathogens should be discharged， and that stasis syndrome should be differentiated as early as possible to prevent it from developing into abdominal mass.关键词：blood stasis;purging method;activating blood and removing stasis;classical formula;Zhang Zhongjing;traditional Chinese medicine therapy
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发布时间：2023-05-16 - 摘要：Professor Liu Jiaxiang， as one of the national traditional Chinese medicine （TCM） masters， has been conducting clinical research on the treatment of malignant tumors with TCM since the 1960s， focusing on the survival， quality of life， and rights and interests of subjects with medications， and emphasizing the scientific， normative and ethical aspects of clinical research in TCM. In this paper， we systematically describe Professor Liu’s initiatives in advocating， practicing and promoting medical ethics in TCM clinical research for nearly 60 years， and introduce his rigorous approach to medical ethics in clinical research， for the purpose of providing valuable experience for the implementation of TCM clinical research and the protection of subjects worldwide.关键词：medical ethics;clinical research;evidence-based medicine;traditional Chinese medicine therapy;tumor
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发布时间：2023-05-16 - 摘要：The pathogenesis and treatment of chronic deafness are discussed from the perspective of phlegm-turbidity. It is considered that the deficiency of spleen， kidney and liver is the root cause of chronic deafness， and phlegm-turbidity coagulating in the ear， together with dampness， blood stasis and liver qi depression， is an important etiological factor in the development of deafness. Wuling Powder and Gualou Xiebai Banxia Decoction are used as the main formulas to resolve phlegm， drain turbidity， and unblock stuffy ear orifice， which should be assisted by the treatment methods of promoting blood circulation for removing obstruction in collaterals， regulating liver and activating qi， and reinforcing healthy qi with an emphasis on strengthening the spleen， tonifying the kidney and benefiting the liver. One proven case is presented.关键词：deafness;sensorineural deafness;phlegm-turbidity;traditional Chinese medicine therapy;clinical experience
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发布时间：2023-05-16 - 摘要：This article summarized Shanghai Style of traditional Chinese medicine of Xu’s Pediatrics’ learning for etiology and pathogenesis of children’s combined allergic rhinitis and asthma syndrome （CARAS） and the TCM clinical diagnosis and treatment experiences. Xu’s Pediatrics believed that the main pathogenesis of children’s CARAS was wind pathogens invading the lung guard， internal stagnation of qi， phlegm dampness， blood stasis， phlegm and blood stasis， obstruction of the airway， loss of lung’s function， and generally accompanied by dysfunctions of the liver， spleen， and kidneys. The main treatment was to expel wind and unblock stuffy orifice， dispel blood stasis， resolve phlegm and relieve asthma. Meanwhile， according to different children’s physiques， the treatment was to prevent illness currence and recurrence. And one proven case was presented.关键词：combined allergic rhinitis and asthma syndrome;children;Xu’s pediatrics;traditional Chinese medicine therapy
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发布时间：2023-05-16 - 摘要：We summarized the clinical experience of Professor Zhao Ruihua in treating abdominal and breast masses in women with the medicinal pair of Ji’neijin （Galli Gigerii Endothelium Corneum） -Yiyiren （Coicis Semen）. It is considered that blood stasis is the basic pathogenesis of abdominal and breast masses in women， and deficiency of healthy qi is the root cause of the disease. The treatment is to eliminate stagnation and remove masses. The medicinal pair of Ji’neijin （Galli Gigerii Endothelium Corneum） -Yiyiren （Coicis Semen） is frequently used in the clinic， which can gently resolve blood stasis without damaging the healthy qi， and strengthen the spleen and stomach to support the healthy qi and dispel the pathogenic qi. Therefore， the incorporation of this medicinal pair in the prescription for activating blood to resolve stasis and benefiting qi to strengthen the spleen has been proved effective in treating abdominal and breast masses in women. One proved case is provided.关键词：endometriosis;breast nodules;abdominal and breast masses;Ji’neijin （Galli Gigerii Endothelium Corneum）;Yiyiren （Coicis Semen）;medicinal pair;expert experience;traditional Chinese medicine therapy
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发布时间：2023-05-16 - 摘要：The article introduces the clinical experience of Professor Liu Hongxiao in differentiating and treating thrombocytopenia secondary to Sjögren’s syndrome with the four methods for treating blood. It is thought that the key pathogenesis of secondary thrombocytopenia involves deficiency， fire and stasis. The clinical treatment is derived from Tang Rongchuan’s four methods for treating blood， which are “bleeding control， stasis removal， blood calming and blood tonifying”， and combines syndrome differentiation. Thereby， therapeutic results are quite satisfactory. One proven case is provided.关键词：Sjogren’s syndrome;thrombocytopenia;immune disease;traditional Chinese medicine therapy;expert experience
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发布时间：2023-05-16 - 摘要：ObjectiveThrough the study on the treatment of limb arthralgia with Aconiti Lateralis Radix Praeparata in the Tang and Song dynasties， the dosage， preparation and matching methods of Aconiti Lateralis Radix Praeparata were summarized， which could guide modern clinical applications.MethodsThrough sorting the prescriptions for the treatment of limb arthralgia in the Tang and Song dynasties， and selecting prescriptions that contained Aconiti Lateralis Radix Praeparata， the use range， dose， preparation and synergy of Aconiti Lateralis Radix Praeparata were analyzed through dosage conversion between ancient and modern times.ResultsIn the Tang and Song dynasties， Aconiti Lateralis Radix Praeparata had a wide range of applications， not only for the bi caused by cold evil， but also for the bi caused by hot evil through drug synergy. Among the three kinds of bi， such as painful bi， migratory bi and stationary bi， Aconiti Lateralis Radix Praeparata was most commonly used for painful bi. In the Tang and Song dynasties， the common dosage of Aconiti Lateralis Radix Praeparata in decoction， pill and powder was similar. The dosage span of decoction was the most， and the maximum dosage was 160 g. The dosage of Aconiti Lateralis Radix Praeparata in powder in Song Dynasty was much lower than that in Tang Dynasty.There was no special decoction method for Aconiti Lateralis Radix Praeparata in limb arthralgia. Aconiti Lateralis Radix and Praeparata-Saposhnikoviae Radix was a common detoxifying drug pair.ConclusionsPain was the opportunity to use Aconiti Lateralis Radix Praeparata. The method of clearing heat could be added accordingly depending on incorporating thermography. In small and medium dosage， conventional decoction might be more effective in anti-inflammatory and analgesic effects without poisoning. Aconiti Lateralis Radix Praeparata and Praeparata-Saposhnikoviae Radix were compatible for treating bi， which could both enhance the effect and reduce the toxicity. In brief， the experience of Aconiti Lateralis Radix Praeparata in the treatment of limb arthralgia in the Tang and Song dynasties had important reference value for the clinical treatment of rheumatology in traditional Chinese medicine.关键词：rheumatic diseases;limb arthralgia;Aconiti Lateralis Radix Praeparata;toxic herbs;dosage;efficacy enhancing and toxicity reducing;literature research
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发布时间：2023-05-16 - 摘要：ObjectiveTo study the effect of Buyi Xiaozheng Prescription （BXP） on the immune microenvironment in the window period of chemotherapy for advanced ovarian cancer， and to observe the clinical efficacy of BXP.MethodsSixty patients diagnosed with advanced ovarian cancer were randomly divided into a control group （n=30） and a treatment group （n=30）. The control group was given conventional chemotherapy， and the treatment group was given the conventional treatment measures of the control group together with the oral administration of BXP. The changes in the number and proportion of CD3+T， CD4+T， CD8+T， CD4+/CD8+T， CD25+Treg and NK cells were compared between the two groups， and the recent clinical efficacy was observed.Results①During the trial， there were 2 drop-out cases in the treatment group and 3 drop-out cases in the control group， and 55 cases finally completed the trial with 28 cases in the treatment group and 27 cases in the control group. ②In terms of recent efficacy comparison， the 12-month treatment efficiency of the treatment group was 42.86% and the tumor control rate was 71.42%， which were better than 33.33% and 44.44% of the control group， respectively （P<0.05）. ③The levels of CD3+T， CD4+T， CD8+T， and CD25+Treg cells were lowered significantly in both groups 7 d after chemotherapy compared with those before treatment （P<0.05）； and the levels of CD3+T， CD4+T， CD8+T， and CD25+Treg cells in the treatment group were higher than those in the control group 14 d and 28 d after chemotherapy （P<0.05）. ④The levels of NK cells in both groups decreased 14 d after chemotherapy compared with those before treatment （P<0.05）； and the levels of NK cells in the treatment group were higher than those in the control group 14 d and 28 d after chemotherapy （P<0.05）.ConclusionBuyi Xiaozheng Prescription can effectively inhibit the progression of advanced ovarian cancer and positively regulate T cells and NK cells in the immune “window period” after chemotherapy， which can temporarily reverse the immune suppression in patients after chemotherapy and provide a good therapeutic environment for further immunotherapy.关键词：ovarian cancer;Buyi Xiaozheng Prescription;chemotherapy;window period;immune regulation;traditional Chinese medicine therapy
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发布时间：2023-05-16 - 摘要：ObjectiveTo study the effects of traditional Chinese medicine （TCM） compound formula WCAP and its sub-formulas on the tumor growth of subcutaneous transplanted human pancreatic cancer BxPC-3 cells in nude mice and on the interleukin-6/signal transducer and activator transcription 3 （IL-6/STAT3） signaling pathway.MethodsThe subcutaneous transplanted tumor model of human pancreatic cancer BxPC-3 cells in nude mice was established. Totally 30 SPF-grade nude mice were randomly divided into 6 groups of 5 mice each， which were blank control group， 5-fluorouracil（5-FU） group， compound group， spleen-invigorating group （SI group）， heat-clearing and toxicity-removing group （HCTR group）， and hardness-resolving group （HR group）. The tumor quality and tumor growth inhibition rate of the subcutaneous transplanted tumor in each group of nude mice were recorded. The mRNA and protein expression levels of IL-6/STAT3 pathway and its downstream target genes c-myc， cyclin D1， VEGF and MMP-2 were detected in tumor tissues by real-time fluorescence quantitative reverse transcription polymerase chain reaction （RT-qPCR） and Western blot， respectively.Results①Each intervention group showed lower tumor weight than that of control group. The 5-FU group， compound group and each sub-formula group could inhibit the growth of subcutaneous transplanted tumor in nude mice （P<0.05）， and the tumor growth inhibition rate of the compound group was higher than that of each sub-formula group（P<0.05）. ②The mRNA expression levels of IL-6/STAT3 pathway and its downstream target genes c-myc， cyclin D1， VEGF and MMP-2 were lowered in the 5-FU group， compound group and HR group than those in the control group （P<0.05）. ③Compared with those in the control group， the protein expression levels of IL-6/STAT3 pathway and its downstream target genes c-myc， cyclin D1， VEGF， and MMP-2 were lowered in the 5-FU group and compound group （P<0.05）， and the protein expression levels of c-myc， MMP-2， and IL-6 were lowered in HR group （P<0.05）.ConclusionsWCAP compound formula could inhibit the tumor growth of subcutaneous transplanted human pancreatic cancer BxPC-3 cells in nude mice， and the mechanism was related to the inhibition of IL-6/STAT3 pathway and regulation of the expression levels of its downstream target genes c-myc， cyclin D1， VEGF， and MMP-2. WCAP compound formula showed a better effect on the tumor growth inhibition rate， mouse weight， and IL-6/STAT3 pathway and its downstream target gene regulation than each sub-formula group.关键词：pancreatic cancer;traditional Chinese medicine compound formula;IL-6/STAT3 pathway;subcutaneous transplanted tumor model in nude mice;traditional Chinese herbal medicine research
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发布时间：2023-05-16 - 摘要：Polycystic ovary syndrome （PCOS） is a common reproductive and endocrine metabolic disorder in women of childbearing age. Due to a highly heterogeneous clinical presentation， PCOS has two phenotypes： obese and non-obese. Hyperandrogenemia and related clinical manifestations are the key pathological features that distinguish obese PCOS from non-obese PCOS， and treatment should vary accordingly. The research progress of TCM treatment of non-obese PCOS is reviewed from three aspects： etiology and pathogenesis， clinical research， and mechanism research. The core pathogenesis of non-obese PCOS is kidney deficiency and liver depression. Traditional Chinese medicine therapy（herbal formulas， single herbs， and acupuncture） can effectively regulate menstrual cycle and sex hormone levels in non-obese PCOS patients， increase ovulation rate， improve clinical manifestations of hyperandrogenism such as hirsutism and acne， increase pregnancy rate and improve pregnancy outcome. The therapeutic mechanism may be related to the regulation of the body’s gut microbiota， inflammatory cytokines， nerve growth factors， and the hypothalamic-pituitary-ovarian axis.关键词：polycystic ovary syndrome;hyperandrogenemia;infertility;kidney deficiency and liver depression syndrome;traditional Chinese herbal medicine;acupuncture;gut microbiota
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发布时间：2023-05-16 - 摘要：The research progress on tripterygium wilfordii and its effective components in the treatment of rheumatoid arthritis was reviewed from three aspects： mechanism of action， reducing poisonousness and improving efficiency， and new drug development. Tripterygium wilfordii main effective components triptolide， celastrol， tripterygium glycosides had anti-inflammatory， inhibition of bone destruction， in addition through dosage form changes， compatibility could increase efficiency and reduce toxicity ； （5R） -5-hydroxy triptolide was a new triptolide derivative with better safety.关键词：rheumatoid arthritis;Tripterygium Wilfordii;mechanism;reducing poisonousness;improving efficiency;new drug research and development;research progress
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发布时间：2023-05-16 - 摘要：The current status in post-stroke rehabilitation research is expounded in terms of symptomatic rehabilitation， psychological rehabilitation and rehabilitation of complications， and the research progress in post-stroke rehabilitation of traditional Chinese medicine （TCM） is reviewed. It is thought that rehabilitation interventions should be provided as early as possible for stroke patients， and the focus of rehabilitation differs for patients with different symptoms. Individualized rehabilitation interventions should be developed and implemented to effectively improve physical mobility， speech impairment， swallowing dysfunction， cognitive dysfunction and post-stroke depression， and to prevent complications such as pulmonary infections and pressure sores.TCM rehabilitation treatment guided by the holistic concept and syndrome differentiation-based treatment can significantly promote the functional recovery in post-stroke patients， and improve their symptoms and quality of life in every way.关键词：stroke;rehabilitation;traditional Chinese medicine therapy;research progress
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发布时间：2023-05-16
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