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Volume 60 期 3，2026 2026年第60卷第3期

    GAO Ling, LIU Hong, JI Guang, XU Hanchen, LIU Lei, ZHANG Jie, JIN Xing, DONG Changsheng, ZHENG Miaomiao, QIN Chentai, WANG Siliang, HAO Miaoxiu, ZHANG Ming, SHI Yulin, FENG Li, LIU Dan, YANG Xi, CHEN Wenlian

    DOI：10.16305/j.1007-1334.2026.z20250825002
    摘要：ObjectiveTo explore the syndrome transformation and metabolic characteristics of spleen deficiency/dampness-heat syndromes of traditional Chinese medicine （TCM） in patients with newly diagnosed esophageal squamous cell carcinoma （ESCC） based on machine learning algorithms.MethodsTwo independent ESCC cohorts were enrolled， namely the discovery cohort and validation cohort， and healthy volunteers were recruited as controls. The Spleen Deficiency/Dampness-Heat Syndrome Patient-Reported Outcome Scale （hereinafter referred to as the PRO Scale） was used to collect and score syndrome information of newly diagnosed ESCC patients. Machine learning K‑means clustering analysis was applied to determine TCM syndromes， and patients were classified into the spleen deficiency syndrome （SDS） group， dampness-heat syndrome （DHS） group， combined syndrome （CS） group （with both spleen deficiency and dampness-heat syndromes）， and non-spleen deficiency/dampness-heat syndrome （NSD/DHS） group. Postoperative PRO Scale data were collected from the discovery cohort and compared with preoperative data to analyze the syndrome transformation and dynamic changes in TCM syndrome manifestations. Fasting peripheral venous blood samples were collected from subjects in the discovery cohort and healthy controls for metabolomic detection and analysis. Additionally， an ESCC cohort with survival information and the corresponding serum metabolomic data from the preliminary study of our research group were included for correlation analysis.Results①A total of 252 newly diagnosed ESCC patients were enrolled， including 147 cases in the discovery cohort and 105 cases in the validation cohort， with 75 healthy controls recruited separately. Complete preoperative PRO Scale data were obtained from all 252 patients. For the discovery cohort， serum samples were collected from 75 patients before treatment， and PRO Scale data on the 10th day after radical surgery were followed up and acquired from 73 of these patients. ②K-means clustering analysis effectively identified TCM syndromes in newly diagnosed ESCC patients. The proportions of spleen deficiency/dampness-heat related syndromes were 40.8% in the discovery cohort and 41.9% in the validation cohort. ③Surgery disturbed spleen deficiency and dampness-heat syndromes in patients and exacerbated the manifestation of yellow， thick and greasy tongue coating.④Metabolomic analysis showed that the metabolic profiles of the DHS group and CS group were significantly deviated from those of the NSD/DHS group. Syndrome-specific metabolites were identified： indoxyl sulfate and pseudouridine for spleen deficiency syndrome； obacunone and threonine for dampness-heat syndrome； ranaconitine and salicylic acid for combined syndrome.⑤Survival analysis indicated that high expressions of indoxyl sulfate， pseudouridine and ranaconitine predicted poor overall survival， whereas high expression of obacunone indicated favorable prognosis.ConclusionsMachine learning-assisted analysis of PRO Scale data can accurately identify TCM syndromes and their dynamic changes in newly diagnosed ESCC patients. Each syndrome corresponds to specific metabolic profiles and characteristic metabolites， and some of these metabolites have independent predictive value for prognosis.  
    关键词：esophageal cancer;machine learning;spleen deficiency syndrome;dampness-heat syndrome;metabolomics;traditional Chinese medicine syndrome;exogenous metabolite   
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    更新时间：2026-03-17

    QIU Manli, SONG Zheyu, CHEN Yuan, ZHAO Chaorong, MA Yuanyuan, TAO Jie, LI Jing

    DOI：10.16305/j.1007-1334.2026.z20250730001
    摘要：Mild cognitive impairment （MCI） is an unstable transitional state between cognitive decline associated with normal brain aging and Alzheimer's disease. In traditional Chinese medicine （TCM）， MCI is classified under conditions such as "amnesia"， and its occurrence is considered to be associated with spleen deficiency. The spleen is regarded as the source of qi and blood transformation， and its function of ascending clear yang is essential for maintaining vitality， providing a continuous postnatal material basis for the storage of "intent and intellect" attributed to the spleen. With aging， spleen deficiency may result in impaired transformation and transportation， insufficient generation of qi and blood， deficiency of nutritive blood， and weakened ascending of clear yang. Consequently， clear yang fails to ascend， the brain orifices are deprived of nourishment， turbid yin is generated internally and ascends to disturb the clear orifices， ultimately leading to dysfunction of mental activities.This pathophysiological interpretation offers an integrated perspective on the multifactorial mechanisms of MCI identified by modern medicine， including lipid metabolism disorders， increased oxidative stress， neuroinflammatory responses， and gut microbiota dysbiosis. As a non-pharmacological therapy that regulates visceral qi dynamics， acupuncture and moxibustion may act on multiple pathological processes of MCI by strengthening the spleen and promoting the ascending of clear yang， thereby improving cognitive function. From the TCM theoretical perspective of treating MCI through the spleen， acupuncture and moxibustion intervention strategies are proposed to provide new insights and clinical references for the comprehensive management of MCI.  
    关键词：mild cognitive impairment;Alzheimer's disease;spleen governs ascending lucidity;acupuncture and moxibustion;lipid metabolism;gut microbiota;oxidative stress;mechanism of action   
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    WANG Ting, LYU Yubao, WANG Xuan, YANG Yi, SU Shiyu, CAO Yuxue, HUANG Dayu

    DOI：10.16305/j.1007-1334.2026.z20251107002
    摘要：Xuefu Zhuyu Decoction， recorded in Yilin Gaicuo （Corrections of Errors in Medical Classics） written by Wang Qingren in the Qing Dynasty， is a classic famous formula for promoting blood circulation and resolving stasis in traditional Chinese medicine. In recent years， this prescription has shown potential value for oncological treatment. Clinical studies have suggested that its combination with chemotherapy can enhance the anti-tumor effect. By systematically reviewing the role of Xuefu Zhuyu Decoction in the treatment of lung cancer， this paper focuses on exploring the pharmacological effects and molecular mechanisms of its active components in inhibiting tumor angiogenesis， blocking metastasis process， regulating cellular senescence， and remodeling the tumor immune microenvironment. The aim is to elaborate the modern scientific connotation of the anti-lung cancer effects of Xuefu Zhuyu Decoction.  
    关键词：Xuefu Zhuyu Decoction;lung cancer;active components;blood stasis syndrome;anti-tumor mechanism;classic famous formula   
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    SUN Meng, HUANG Yi, WU Di, LIU Tong, SHI Mengyao, XU Haoran, HAN Mingxiang, LI Zegeng

    DOI：10.16305/j.1007-1334.2026.z20250817002
    摘要：This paper introduces the clinical experience of National Master of Traditional Chinese Medicine Han Mingxiang in the diagnosis and treatment of allergic rhinitis based on the theory that “the nose serves as the orifice of the lung”.Based on this theory， Professor Han Mingxiang posits that the core pathogenesis of allergic rhinitis involves dysfunction of the lung leading to obstruction of the nasal orifice. Specifically， the fundamental cause lies in the failure of the lung to disperse and descend， resulting in nasal blockage； the predisposing factor is the invasion of wind pathogens into the lung and weakness of the defensive exterior； and the key to persistent recurrence is deficiency of both the lung and spleen with depletion of vital qi. The treatment should adhere to the principle of regulating the lung and unblocking the nasal orifice. During the acute phase， the approach focuses on dispelling wind， dispersing the lung， and unblocking the orifice， utilizing modified formulations of Shengjiang San combined with Jingfang Baidu San. In the remission phase， treatment aims to tonify the lung， boost qi， and consolidate the exterior， employing modified formulations of Yupingfeng San combined with Wenfei Tang. During the stable phase， the strategy involves reinforcing both the lung and spleen， strengthening vital qi， and consolidating the foundation， using modified formulations of Liu Junzi Tang combined with Huangqi Jianzhong Tang.  
    关键词：allergic rhinitis;traditional Chinese medicine therapy;syndrome differentiation and treatment;experience of renowned physician   
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    MA Xiaomin, LIU Zhen, YANG Yumeng, LI Jiaochang, ZHANG Tianyu, ZHANG Wenhan, WU Zhenqi

    DOI：10.16305/j.1007-1334.2025.z20250217003
    摘要：ObjectiveTo systematically review the clinical efficacy and safety of traditional Chinese medicine （TCM） compound prescriptions in the treatment of post-infectious cough （PIC） in children.MethodsA computer-based search was conducted in eight databases， including China National Knowledge Infrastructure （CNKI）， WanFang Data， VIP （Chinese Journals Service Platform）， SinoMed， PubMed， Embase， Cochrane Library， and Web of Science， for relevant literature on the treatment of PIC in children， with publication dates from the inception of the databases up to December 10， 2024. The quality of the included studies was assessed using the Cochrane Handbook for Systematic Reviews of Interventions， and meta-analysis was performed using Review Manager 5.4 software.Results①A total of 17 studies were included， involving 1，296 children （691 males， and 605 females） aged 1 to 17 years. ②The risk of bias in the included studies was assessed using the RoB 2 tool， indicating some studies had potential bias risks. ③Meta-analysis results showed that the experimental group had a higher clinical efficacy rate and better TCM syndrome efficacy than the control group ［RR=1.18， 95% CI （1.13， 1.24）， P<0.000 01； RR=1.38， 95% CI （1.14， 1.68）， P=0.001］. The experimental group also showed better improvement in cough， expectoration， and TCM syndrome scores ［SMD=-0.67， 95% CI （-0.84，-0.50）， P<0.000 01； SMD=-0.52， 95% CI （-0.82， -0.21）， P=0.000 9； SMD=-1.02， 95% CI （-1.21， -0.82）， P<0.000 01］. The experimental group had a shorter onset and cure time than the control group ［SMD=-1.10， 95% CI （-1.82， -0.37）， P=0.003； SMD=-0.38， 95% CI （-0.71， -0.05）， P=0.02］. The recurrence rate of PIC in children of the experimental group was lower than that in the control group ［RR=0.34， 95% CI （0.12， 0.95）， P=0.04］. 10 articles included in the literature reported adverse reactions， but no adverse events occurred.ConclusionsCompared to Western medicine， the use of TCM compound prescriptions alone is more effective in improving cough， expectoration， and TCM syndrome symptoms in children with PIC. It also enhances clinical efficacy， shortens treatment time， and demonstrates high safety. However， the limited number and quality of the included studies require further validation of these findings.  
    关键词：post-infectious cough;children;Chinese materia medica;Meta-analysis;evidence-based medicine   
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Shanghai Journal of Traditional

Chinese Medicine

 

 
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  • Cover Inscription：SHEN Yanbing
  • Supervisor：Shanghai Municipal Education Commission
  • Sponsors：Shanghai University of Traditional Chinese Medicine  
  • Shanghai Association of Traditional Chinese Medicine
  • Editor-in-Chief：YAN Shiyun
  • President：NI Liqiang
  • Director of Editorial Department：HUANG Botao
  • ISSN：1007-1334
  • CN：31-1276/R
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