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Volume 60 期 5，2026 2026年第60卷第5期

    JING Xiaoshuo, WEI Yanbo, LIAO Yating, ZHANG Shaohui, YANG Ping, ZHAO Guoying, YAN Junfeng

    DOI：10.16305/j.1007-1334.2026.z20250813005
    摘要：With the rapid advancement of artificial intelligence， generative large language models （LLMs） have attracted growing attention for their potential applications in the medical field. This study evaluates six representative generative LLMs—including four general-purpose models and two specialized models for traditional Chinese medicine （TCM）—on a constructed dataset of TCM medical records related to mental disorders. A comprehensive comparison was conducted from two aspects： the models' diagnostic and therapeutic capabilities， and the quality of their generated outputs， aiming to assess their applicability in the diagnosis and treatment of mental disorders within TCM. The results show that while all models demonstrate certain competence in this domain， their performance varies significantly. Under the specific test conditions and specific dataset of this study， DeepSeek， Ernie Bot， and ChatGLM exhibited relatively outstanding overall applicability. Specialized TCM models， however， still show room for improvement in areas such as depth of data processing， integration of domain knowledge， and clinical logical reasoning. Looking forward， with the continuous expansion of high-quality TCM datasets， ongoing optimization of model architectures， and the gradual improvement of clinical validation systems， the application prospects of generative LLMs in the field of TCM are expected to broaden considerably.  
    关键词：generative artificial intelligence;large language model;traditional Chinese medicine;mental disorders;diagnosis;treatment   
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    SHI Hong, DAI Yancheng, MA Guizhi, LIU Lusheng, ZHANG Haitang, GUO Jinsheng

    DOI：10.16305/j.1007-1334.2026.z20251210001
    摘要：Irritable bowel syndrome （IBS） is a common functional bowel disease that significantly impacts patients' quality of life. This paper reviews the basic and clinical research progress on the mechanism， methods and therapeutic effects of acupuncture and moxibustion for IBS in recent years， aiming to provide references for further investigation and standardized clinical application. Acupuncture and moxibustion have demonstrated definite therapeutic effects on IBS， with significant advantages particularly in relieving core symptoms （abdominal pain and diarrhea）， improving quality of life and emotional disorders （anxiety and depression） in patients with diarrhea-predominant IBS （IBS-D）. The treatment emphasizes individualized acupoint selection， and focuses on "treatment based on syndrome differentiation" and "standardized operation". Its mechanisms involve regulating peripheral and central pain conduction， balancing the secretion of brain-gut peptides， remodeling the intestinal microecosystem， and reducing visceral hypersensitivity.  
    关键词：irritable bowel syndrome;acupuncture and moxibustion;anxiety;depression;brain-gut peptide;gut microbiota;research progress   
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    ZHANG Jingzhi, SHI Dongping, LIU Zhiheng, FAN Xutong, ZHANG Yuping, YUAN Bing

    DOI：10.16305/j.1007-1334.2026.z20250718006
    摘要：By systematically reviewing ancient and modern literature， this paper conducts textual research and analysis on the historical evolution and key information of the classic formula Qiangen San from seven aspects： historical origin， medicinal composition， dosage， decoction and administration methods， medicinal origin and processing， formula interpretation as well as efficacy and indications， and modern clinical application. It provides a theoretical reference for the clinical application and subsequent research and development of classic famous formula Qiangen San.  
    关键词：classic famous formula;Qiangen San;textual research;key information;clinical application   
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    ZHOU Linqiong, ZHANG Wei

    DOI：10.16305/j.1007-1334.2026.z20251007003
    摘要：Metabolic reprogramming of macrophages plays a critical role in the immune response to viral infections. Viral infection induces a shift in macrophage metabolism from oxidative phosphorylation to enhanced glycolysis， driving pro-inflammatory M1 polarization. This process exacerbates inflammatory responses and tissue damage， ultimately forming a pathological pattern characterized by "healthy qi （Zheng Qi） deficiency and pathogenic factors （Xie Qi） excessiveness". The struggle between healthy qi and pathogenic factors and metabolism-immune disorders run through the disease process of influenza. Mitochondrial dysfunction inhibits oxidative phosphorylation， weakening the anti-inflammatory and repair ability of M2 macrophages and creating a microenvironment susceptible to invasion by external pathogenic factors. The exuberance of these pathogenic factors induces disease by promoting the excessive activation of glycolysis-dependent M1 macrophages and the release of proinflammatory cytokines， resulting in the inflammatory damage characteristic of a state where "healthy qi fails to overcome pathogenic factors". With healthy qi deficiency and pathogenic factors excessiveness as the core pathogenesis of influenza， treatment should place equal emphasis on strengthening healthy qi and eliminating pathogenic factors. Based on the theory of "Zheng and Xie"， this study systematically elucidates the pathological mechanism of "metabolic disorder–inflammatory-immune imbalance" in influenza， while exploring the role of traditional Chinese medicine in regulating macrophage metabolic phenotypes and preventing/treating influenza. The findings provide insights for clinical application and promote the deep integration of classical theories with modern diagnosis and treatment systems.  
    关键词：influenza;theory of healthy qi and pathogenic factors;macrophages;metabolic reprogramming;immunoregulation;traditional Chinese medicine therapy   
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    更新时间：2026-04-30

    WANG Yirong, WANG Xue, GUO Haijing, SUN Yunhong, DAI Liang, MAO Xiyan, WANG Kai, JI Guang, ZHOU Wenjun

    DOI：10.16305/j.1007-1334.2026.z20250818003
    摘要：ObjectiveTo investigate the mechanism by which Linggui Zhugan Decoction （LGZG） alleviates methionine-choline-deficient （MCD） diet-induced metabolic dysfunction-associated steatohepatitis （MASH） via modulation of lysophosphatidylcholine （LPC） metabolism.Methods①The chemical constituents of LGZG were identified using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry （UPLC-Q-TOF/MS）， and a “compound-target-pathway” network was constructed via network pharmacology to predict the key signaling pathways involved. ②The MASH model SD rats were randomly divided into model group， LGZG group （16.56 g·kg⁻¹·d⁻¹）， vitamin E group （40 mg·kg⁻¹·d⁻¹）， and normal control group （n=6）， with intervention for 4 weeks. The levels of alanine aminotransferase （ALT） and aspartate aminotransferase （AST） in rat serum， as well as the levels of triglycerides （TG） and total cholesterol （TC） in the liver were measured. Histopathological changes and lipid deposition of liver were assessed via hematoxylin-eosin （HE） and oil red O staining. Hepatic protein expression levels of peroxisome proliferator-activated receptor （PPAR）α， PPARγ coactivator 1α （PGC1α）， carnitine palmitoyltransferase 1a （CPT1a）， and major facilitator superfamily domain-containing protein 2a （Mfsd2a） were determined by Western blot. Hepatic metabolomics was employed to analyze alterations in the LPC metabolic profile. ③An AML12 hepatocyte lipid deposition model was established， and after intervention with LPC （18∶0）， the cell viability was determined by the CCK-8 assay， while lipid deposition was evaluated by oil red O staining and TG content measurement. The activation effect of the PPARα pathway by LPC（18∶0） was validated using Western blot and a luciferase reporter gene assay.Results①Network pharmacology analysis indicated that the PPAR signaling pathway is a potential key pathway for LGZG in treating MASH. ②In vivo experiments showed that LGZG could significantly reduce the serum ALT and AST levels and hepatic TG level in the rats， as well as improve liver steatosis， inflammatory infiltration and NAS score. The mechanism is related to the upregulation of liver PPARα， PGC1a， and CPT1a protein expressions， as well as the increase in phosphorylated acetyl-CoA carboxylase （p-ACC） level. Metabolomics studies revealed that LGZG significantly reversed the downregulation of various LPCs in the liver of MASH rats. Among them， the level of LPC（18∶0） significantly increased， accompanied by the upregulation of the Mfsd2a transporter protein expression. Correlation analysis revealed a significant inverse relationship between hepatic TG levels and LPC（18∶0） content. ③Cell experiments further confirmed that LPC（18∶0） could dose-dependently reduce the TG level in hepatocytes， activate PPARα transcriptional activity， and up-regulate CPT1a protein expression and the p-ACC/ACC ratio.ConclusionsLGZG may promote the accumulation of endogenous LPC（18∶0） by regulating Mfsd2a， and then activate the PPARα signaling pathway， thereby improving the lipid metabolism disorder in MASH liver by promoting fatty acid β-oxidation and inhibiting lipid de novo lipogenesis.  
    关键词：metabolic dysfunction-associated steatohepatitis;Linggui Zhugan Decoction;UPLC-Q-TOF/MS;network pharmacology;metabolomics;lipid metabolism;classic famous formula   
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Shanghai Journal of Traditional

Chinese Medicine

 

 
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  • Cover Inscription：SHEN Yanbing
  • Supervisor：Shanghai Municipal Education Commission
  • Sponsors：Shanghai University of Traditional Chinese Medicine  
  • Shanghai Association of Traditional Chinese Medicine
  • Editor-in-Chief：YAN Shiyun
  • President：NI Liqiang
  • Director of Editorial Department：HUANG Botao
  • ISSN：1007-1334
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