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Volume 60 期 10，2026 2026年第60卷第10期

    Shen Fengying, Cai Zhongli, Chen Yun, Lao Zongding, Li Zhen, Fei Lingzhi

    DOI：10.16305/j.1007-1334.2026.z20250327006
    摘要：ObjectiveTo develop machine learning-based models for predicting the efficacy of acupuncture in patients with functional dyspepsia （FD） and to explore their utility in clinical decision support， thereby enhancing the personalization and effectiveness of acupuncture therapy.MethodsThis retrospective study collected clinical data from 2 584 patients with FD treated at the 72nd Group Army Hospital of the Chinese People's Liberation Army between April 2023 and October 2024， which served as the internal dataset ［internal training set （n=2 067）； internal testing set （n = 517）］. Concurrently， data from 276 patients with FD at the First People's Hospital of Huzhou were gathered as the external dataset （external testing set）. All patients received 20 acupuncture sessions over a 4-week period and completed the Nepean Dyspepsia Symptom Index （NDSI） and the Nepean Dyspepsia Life Quality Index （NDLQI）. Automated machine learning （AutoML） was used to construct predictive classification and regression models based on 28 distinct features. Comparative analyses were performed against conventional machine learning algorithms， including logistic regression， support vector machine， and extreme gradient boosting （XGBoost）.Results①In the predictive classification model， the critical features influencing response to acupuncture were ranked as follows： education level， sex， disease type， NDSI upper abdominal bloating score， NDSI upper abdominal pressure score， and NDSI irregular diet score. In the predictive regression model， the primary features impacting quality of life were education level， sex， disease type， NDLQI eating dimension score， and NDLQI knowledge/control dimension score. ②AutoML achieved the superior predictive performance across both internal and external testing sets for both classification and regression tasks. ③In the external testing set， the AutoML classification model yielded an area under the receiver operating characteristic curve （ROC-AUC） of 0.914 7 and a precision-recall AUC （PR-AUC） of 0.915 7， while the AutoML regression model achieved a coefficient of determination（R²）of 0.863 3. ④For classification prediction on the internal testing set， AutoML retained a high sensitivity of 98.15% while improving specificity to 77.72% compared with conventional models， significantly mitigating false-positive risks. ⑤For regression prediction on the external testing set， AutoML demonstrated a mean absolute error （MAE） of only 2.651 4， representing a 23.11% reduction compared with XGBoost， and a lower root mean square error-to-MAE ratio （RMSE/MAE） of 1.488.ConclusionsThis study established AutoML models to predict the clinical efficacy of acupuncture in patients with functional dyspepsia and developed a corresponding clinical decision support system. These predictive models hold promise for assisting clinicians in predicting patient responsiveness to acupuncture， thereby enabling the tailoring and adjustment of personalized acupuncture regimens， which may improve clinical outcomes in functional dyspepsia and optimize healthcare resource utilization.  
    关键词：functional dyspepsia;acupuncture;efficacy prediction;machine learning;artificial intelligence   
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    更新时间：2026-10-08

    Qi Qin, Chen Liming, Deng Zhihui, Huang Yan, Ma Zhe, Li Guona, Liu Huirong, Zheng Handan, Wang Zhaoqin, Wu Luyi

    DOI：10.16305/j.1007-1334.2026.z20251201006
    摘要：ObjectiveTo investigate the mechanism by which moxibustion restores the intestinal mucosal barrier in Crohn disease （CD） by regulating the histone deacetylase 2 （HDAC2）- mediated vitamin D receptor （VDR）/nuclear factor κB （NF-κB） pathway.MethodsTwenty-six healthy male SD rats were given 2，4，6-trinitrobenzenesulfonic acid solution （3 mL/kg， once weekly for 4 consecutive weeks） to establish the CD model. After modeling， 2 rats were randomly selected for model validation. The rats that met the modeling criteria were randomly assigned to 3 groups： a model group， a moxibustion group， and an inhibitor group， with 8 rats in each； While 8 healthy rats were used as the normal group. The moxibustion group received herb-partitioned moxibustion at bilateral Tianshu （ST25） and Qihai （CV6）， while the inhibitor group was intraperitoneally injected with the HDAC inhibitor entinostat （MS-275）， once daily for 7 consecutive days. Macroscopic colon damage and histopathological changes were scored. HE staining was performed to evaluate histopathological alterations in colon tissue， followed by scoring. Western blot was used to detect protein expression of HDAC2， VDR， NF-κB p65， occludin and zonula occludens protein-1 （ZO-1）. Immunohistochemistry was used to observe the protein localization and expression of VDR， NF-κB p65， occludin and ZO-1 in the colon. Real‑time fluorescence quantitative reverse transcription PCR （RT-qPCR） was used to measure mRNA expression of VDR and NF‑κB. The interaction between VDR and NF-κB p65 was detected by the co-immunoprecipitation （Co-IP）.ResultsCompared with the control group， the model group showed significantly higher colon gross injury score， colon tissue histological scores as well as expression levels of HDAC2， NF-κB p65 protein and NF-κB mRNA， while significantly lower expression levels of VDR protein and mRNA as well as occludin and ZO-1 proteins. Compared with the model group， the moxibustion group and the inhibitor group showed significantly lower colon gross injury scores， colon tissue histological scores， as well as expression levels of HDAC2 and NF-κB proteins as well as NF-κB mRNA， while significantly higher expression levels of VDR protein and mRNA as well as occludin and ZO-1 proteins. In addition， an interaction between VDR and NF‑κB p65 was confirmed.ConclusionMoxibustion can restore the intestinal mucosal barrier of CD rats by regulating the expression of key proteins in the HDAC2-mediated VDR/NF-κB pathway and upregulating the expression of tight junction proteins occludin and ZO-1.  
    关键词：Crohn disease;moxibustion;intestinal mucosal barrier;histone deacetylase;tight junction protein;mechanism of action   
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    更新时间：2026-10-08

    Liu Yang, Liao Yaqi, Bao Wenchu, Yan Rong, Wang Chen

    DOI：10.16305/j.1007-1334.2026.z20260403002
    摘要：This paper investigates the value of intestinal ultrasound （IUS） and magnetic resonance imaging （MRI） in the diagnosis and evaluation of Crohn disease （CD） from an integrated traditional Chinese and Western medicine perspective. IUS and MRI can address the limitations of the four diagnostic methods in traditional Chinese medicine （TCM）， specifically the concept of "inferring internal pathology from external manifestations"， thereby offering quantifiable reference points for CD syndrome differentiation and therapeutic effect evaluation. The combined application of IUS and MRI facilitates the development of an integrated diagnostic and therapeutic system that "couples disease differentiation with syndrome differentiation" in CD. Future prospective studies are needed to validate the correlations between imaging parameters and clinical outcomes of traditional Chinese medicine interventions.  
    关键词：Crohn disease;intestinal ultrasound;magnetic resonance imaging;integrated traditional Chinese and western medicine;diagnosis   
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    更新时间：2026-10-08

    Zhang Hui, Li Wei, Yan Shuxin, Li Chenlin, Zhong Xianggen

    DOI：10.16305/j.1007-1334.2026.z20260129009
    摘要：By systematically sorting out herbal works， formularies and non-medical literature， the authenticity and evolutionary trajectory of the tonic effect of Alismatis Rhizoma were verified. The results showed that Alismatis Rhizoma indeed possesses the effect of tonifying and nourishing the body. It can reinforce the kidney， relieve seminal emission caused by deficiency， and treat deficiency and consumptive diseases. During the Han and Tang Dynasties， tonifying consumptive damage was one of the core effects of Alismatis Rhizoma， which was widely applied for five labors and seven injuries as well as visceral consumptive damage. Since the Song Dynasty， possibly influenced by Faxiang pharmacology， the efficacy cognition of Alismatis Rhizoma has shifted towards "valuing diuresis over tonification". By the Ming and Qing Dynasties， academics either interpreted it as indirect nourishment or completely denied it， leading to the gradual vanishing of its ancient meaning. Re-exploring the tonic function of Alismatis Rhizoma can not only clarify its historical evolution， but also provide enlightenment for the modern clinical application and development.  
    关键词：Alismatis Rhizoma;nourishing five zang-organs;tonification;Chinese materia medica;efficacy   
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    更新时间：2026-10-08

    Jiang Wenyu, Ma Jie, Shen Lin, Yan Hua, Yan Shiyun

    DOI：10.16305/j.1007-1334.2026.z20251127005
    摘要：Cancer therapy-related cardiac dysfunction （CTRCD） is a chronic cardiac dysfunction induced by antineoplastic treatments. Based on the visceral manifestation syndrome differentiation system， Professor Yan Shiyun， as a master of traditional Chinese medicine in China， proposes that the fundamental pathogenesis of CTRCD is primarily attributed to the deficiency of heart and kidney yang qi， complicated by the internal obstruction of blood stasis and toxicity from tumor therapies.Therefore， CTRCD manifests as a complex syndrome of root-deficiency and branch-excess. This paper explores Professor Yan's academic thoughts and clinical experience in treating CTRCD with the therapeutic method of consolidating the root and strengthening the heart， activating blood and resolving toxicity to treat CTRCD， aiming to provide novel insights and therapeutic methods for clinical practice.  
    关键词：cancer;cardiac dysfunction;cardio-oncology;Qiangxinyin Formula;traditional Chinese medicine therapy;famous doctor's experience   
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    更新时间：2026-10-08
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Shanghai Journal of Traditional

Chinese Medicine

 

 
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  • Cover Inscription：SHEN Yanbing
  • Supervisor：Shanghai Municipal Education Commission
  • Sponsors：Shanghai University of Traditional Chinese Medicine  
  • Shanghai Association of Traditional Chinese Medicine
  • Editor-in-Chief：YAN Shiyun
  • President：NI Liqiang
  • Director of Editorial Department：HUANG Botao
  • ISSN：1007-1334
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