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1.上海中医药大学中医健康服务协同创新中心(上海 201203)
2.上海中医药大学科技实验中心(上海 201203)
3.上海中医药大学技术转移中心(上海 201203)
杨喜梅,女,硕士研究生,主要从事中药新药研发及质量评价研究工作
刘梅,副研究员,硕士研究生导师; E-mail:liumeiy@aliyun.com
收稿:2025-05-24,
纸质出版:2025-10-10
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杨喜梅,冯静文,张磊,等.车前子在泌尿系统疾病中的药理作用机制及临床应用研究进展[J].上海中医药杂志,2025,59(10):94-100.
YANG Ximei,FENG Jingwen,ZHANG Lei,et al.Plantaginis Semen in urinary system diseases: research progress on pharmacological mechanisms and clinical applications[J].Shanghai Journal of Traditional Chinese Medicine,2025,59(10):94-100.
杨喜梅,冯静文,张磊,等.车前子在泌尿系统疾病中的药理作用机制及临床应用研究进展[J].上海中医药杂志,2025,59(10):94-100. DOI: 10.16305/j.1007-1334.2025.z20250524002.
YANG Ximei,FENG Jingwen,ZHANG Lei,et al.Plantaginis Semen in urinary system diseases: research progress on pharmacological mechanisms and clinical applications[J].Shanghai Journal of Traditional Chinese Medicine,2025,59(10):94-100. DOI: 10.16305/j.1007-1334.2025.z20250524002.
泌尿系统疾病包含肾小球肾炎、尿路感染、肾结石、前列腺疾病等多种类型。车前子通过抗炎、抗氧化、抗细胞凋亡及上皮间质转化、调节水通道蛋白等在泌尿系统疾病中发挥作用。其制剂在尿路感染、肾结石及慢性前列腺炎等疾病中疗效显著,能提高有效率、降低复发率,且安全性较高。现对车前子在泌尿系统疾病中的作用机制及临床应用进行综述,为后续临床研究提供依据。
Urinary system diseases encompass a diverse range of types, including glomerulonephritis, urinary tract infections (UTIs), kidney stones, and prostate disorders. Plantaginis Semen exerts therapeutic effects on these conditions through multiple mechanisms, such as anti-inflammatory, antioxidant, and anti-apoptotic activities, inhibition of epithelial-mesenchymal transition, and regulation of aquaporins. Compound formulations containing Plantaginis Semen have demonstrated remarkable efficacy in treating UTIs, kidney stones, and chronic prostatitis, enhancing therapeutic effectiveness, reducing recurrence rates, and exhibiting a favorable safety profile. This review summarizes recent research advances in the pharmacological mechanisms and clinical applications of Plantaginis Semen for urinary system diseases, aiming to provide a reference for its further clinical application.
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