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1.上海中医药大学附属市中医医院妇科(上海 200071)
2.上海市老年医学中心(复旦大学附属中山医院闵行院区)妇科(上海 201110)
Received:09 July 2025,
Published:10 April 2026
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李佾晟,许华,万怡婷,等.糖酵解代谢重编程与子宫内膜异位症不孕的相关机制及中西医治疗进展[J].上海中医药杂志,2026,60(4):93-100.
LI Yisheng,XU Hua,WAN Yiting,et al.Mechanism of glycolytic metabolic reprogramming and infertility caused by endometriosis and treatment progress of traditional Chinese and Western medicine[J].Shanghai Journal of Traditional Chinese Medicine,2026,60(4):93-100.
李佾晟,许华,万怡婷,等.糖酵解代谢重编程与子宫内膜异位症不孕的相关机制及中西医治疗进展[J].上海中医药杂志,2026,60(4):93-100. DOI: 10.16305/j.1007-1334.2026.z20250709004.
LI Yisheng,XU Hua,WAN Yiting,et al.Mechanism of glycolytic metabolic reprogramming and infertility caused by endometriosis and treatment progress of traditional Chinese and Western medicine[J].Shanghai Journal of Traditional Chinese Medicine,2026,60(4):93-100. DOI: 10.16305/j.1007-1334.2026.z20250709004.
归纳糖酵解促进子宫内膜异位症(EMs)发展及导致不孕的发病机制,并综述中西医在抗糖酵解治疗EMs方面的研究进展。研究证明,EMs中存在糖酵解代谢重编程现象,以葡萄糖摄取增加、糖酵解相关酶活性增强、乳酸产生增多等为主要特征,其可促进EMs病情进展并降低卵泡质量及卵巢储备功能、损害子宫内膜容受性、影响盆腔微环境等。西药主要通过抑制葡萄糖的摄取、调节糖酵解相关酶及重要调控因子的表达而抗糖酵解,中药单体及中药提取物可通过多途径、多靶点有效降低糖酵解通量而治疗EMs。
This paper summarizes the pathogenesis by which glycolysis promotes the development of endometriosis (EMs) and leads to infertility, and reviews the research progress in the anti-glycolysis treatment of EMs in both traditional Chinese medicine and Western medicine.Research has demonstrated that there is a phenomenon of glycolytic metabolic reprogramming in EMs. It is mainly characterized by increased glucose uptake, enhanced activities of glycolysis-related enzymes, and increased lactate production. This phenomenon promotes the progression of EMs, reduces the quality of follicles and ovarian reserve function, impairs endometrial receptivity, and affects the pelvic microenvironment.In Western medicine, anti-glycolysis is mainly achieved by inhibiting glucose uptake and regulating the expression of glycolysis-related enzymes and key regulatory factors. Monomers and extracts of traditional Chinese medicine can effectively reduce glycolytic flux and treat EMs through multiple pathways and multiple targets.
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