Objective

2

To explore the combined characteristics of pulse sound and pulse pressure and the features of common pulse conditions in healthy adolescents， and to provide a traditional Chinese medicine （TCM） data-based auxiliary diagnostic basis for the assessment of adolescent physical health and early prevention of diseases.

Methods

2

A total of 213 enrolled subjects were divided into an adolescent group （

n

=103） and a young adult group （

n

=110） by age. The self-developed MYY-1 Pulse and Pulse Sound Intelligent Auscultator by the research team was used to collect and analyze the characteristic information and differences of pressure pulse waves and pulse sounds under different pulse conditions and age groups， and to explore the correlation between the time-frequency data of pressure pulse waves and the frequency-domain data of pulse sounds.

Results

2

①Compared with the young adult group， the adolescent group had significantly higher h

5

， t

1

/t， and t

4

/t

5

among the time-domain indices of pressure pulse waves （

P

<

0.05）， significantly lower h

3

， h

4

， h

3

/h

1

， h

4

/h

1

， t， t

4

， and t

5

of the same indices （

P

<

0.05）， significantly higher frequency-domain indices of pressure pulse waves including ApEn， MSF， RMSF， FV， FSD and PF1 （

P

<

0.05）， and significantly higher frequency-domain indices of pulse sounds such as E， MSF， RMSF， FV and FSD （

P

<

0.05）. The trend of results in the female subgroup was consistent with the general trend. ②Compared with the young adult group， the adolescent group had a lower pressure pulse wave time-domain index t

4

across

the slippery and wiry pulses （

P

<

0.05）； in the slippery pulse， the adolescent group had lower h

4

， t， t

5

， h

3

/h

1

， h

4

/h

1

（

P

<

0.05） but higher h

5

and t

1

/t （

P

<

0.05）； in the wiry pulse， this group had lower t and t

5

（

P

<

0.05） but higher t

1

/t and t

4

/t

5

（

P

<

0.05）. The adolescent group also had higher pressure wave frequency-domain indices including MSF， RMSF， FV and FSD across the normal， slippery and wiry pulses （

P

<

0.05）； in the slippery pulse， ApEn， PF1， PA2 and PA3 were higher （

P

<

0.05）； in the wiry pulse， ApEn， PF1 and PF2 were higher （

P

<

0.05）， while PF3 and PA3 were lower （

P

<

0.05）. Additionally， the adolescent group exhibited higher pulse sound frequency-domain indices including MSF， RMSF， FV and FSD in the normal and slippery pulses （

P

<

0.05）， with a higher E index in the slippery pulse alone （

P

<

0.05）. The results in the female subgroup were consistent with the over all trends. ③Compared with normal pulse， slippery pulse showed higher pressure pulse wave time-domain indices including h

5

， t

1

， t

1

/t （

P

<

0.05） but lower h

4

， t， t

4

， t

5

， h

3

/h

1

， h

4

/h

1

（

P

<

0.05）， while wiry pulse had higher h

4

/h

1

， t

1

/t， w/t （

P

<

0.05）. Compared with slippery pulse， wiry pulse showed higher pressure pulse wave time-domain indices including h

4

， h

3

/h

1

， h

4

/h

1

， w/t （

P

<

0.05） but lower h

5

（

P

<

0.05）. Compared with normal pulse， slippery pulse showed higher pressure pulse wave frequency-domain indices including

ApEn， MSF， RMSF， FV， FSD， PF1， PA2 and PA3 （

P

<

0.05）. Compared with slippery pulse， wiry pulse showed a higher pressure pulse wave frequency-domain index PF3 （

P

<

0.05） but lower PA2 and PA3 （

P

<

0.05）. Pulse sound frequency-domain analysis revealed statistically significant differences in the E index among normal， wiry and slippery pulses （

P

<

0.05）. ④The correlation between the time-domain and frequency-domain indices of pressure pulse waves was most significant in the total population and the adolescent population （

P

<

0.05）.

Conclusions

2

The pulse conditions of adolescents present age-specific characteristics of "high energy and rapid conduction"， suggesting a vigorous metabolic state of the cardiovascular system in adolescents. The combined characteristic analysis of pulse sound and pulse pressure provides a new quantifiable TCM diagnostic method for the early screening of sub-health status in adolescents.