Research progress on chemical constituents, pharmacological effects and clinical applications of Glycyrrhizae Radix et Rhizoma

Wang Yixiao; Wang Nan; Yang Jun; Lim Xue Yee; Wu Xingyi; Zhang Tong; Li Ling

doi:10.16305/j.1007-1334.2025.z20250903005

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Research progress on chemical constituents, pharmacological effects and clinical applications of Glycyrrhizae Radix et Rhizoma

更新时间：2026-06-09

- Research progress on chemical constituents, pharmacological effects and clinical applications of Glycyrrhizae Radix et Rhizoma
- Shanghai Journal of Traditional Chinese Medicine (2026)
- 作者机构：
  
  1.上海中医药大学中药学院（上海 201203）
  2.上海市黄浦区香山中医医院药剂科（上海 200020）
  3.上海中医药大学国际教育学院（上海 201203）
  4.上海中医药大学经方与现代中药融合创新全国重点实验室（上海 201203）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2025.z20250903005
  CLC：
- Received：03 September 2025，
  
  Revised：2026-05-27，
  
  Accepted：07 June 2026，
- 稿件说明：
移动端阅览
Wang Yixiao, Wang Nan, Yang Jun, et al. Research progress on chemical constituents, pharmacological effects and clinical applications of Glycyrrhizae Radix et Rhizoma[J/OL]. Shanghai Journal of Traditional Chinese Medicine, 2026.
DOI：

Wang Yixiao, Wang Nan, Yang Jun, et al. Research progress on chemical constituents, pharmacological effects and clinical applications of Glycyrrhizae Radix et Rhizoma[J/OL]. Shanghai Journal of Traditional Chinese Medicine, 2026. DOI： 10.16305/j.1007-1334.2025.z20250903005.

摘要

甘草为豆科植物甘草、胀果甘草或光果甘草的干燥根及根茎，具有补脾益气、润肺止咳、清热解毒以及调和诸药的功效，其应用历史源远流长，是重要的补虚解毒药。近年来，学界对甘草开展了大量有关化学成分、药理作用和临床应用方面的研究，证实甘草化学成分主要包括三萜皂苷类、黄酮类、多糖类、香豆素类等化合物，以及多种氨基酸及挥发油；药理研究表明甘草具有抗肿瘤、抗病毒、抗炎、保护神经等作用；临床研究表明，甘草可用于治疗呼吸道疾病、胃肠道疾病、皮肤疾病等。参考近年来甘草的相关文献，从化学成分、药理作用及其临床应用等方面对甘草进行系统综述，助力甘草的基础研究与产业化发展。

Abstract

Glycyrrhizae Radix

Rhizoma (Gancao) is the dried roots and rhizomes of

Glycyrrhiza uralensis

Fisch

Glycyrrhiza inflata

Bat

Glycyrrhiza glabra

L. It possesses the efficacy of tonifying the spleen

reinforcing Qi

moistening the lungs to relieve cough

clearing heat and detoxifying

as well as harmonizing the properties of other medicinal herbs. With a long history of application

it serves as an important herb for replenishing deficiency and detoxification. In recent years

researchers have conducted extensive studies on the chemical constituents

pharmacological actions

and clinical applications of glycyrrhiza. These studies have confirmed that its chemical profile primarily comprises triterpenoid saponins

flavonoids

polysaccharides

coumarins

along with various amino acids and volatile oils. Pharmacological studies have demonstrated that glycyrrhiza possesses antitumor

antiviral

anti-inflammatory

and neuroprotective effects

etc. Clinical research has indicated its applicability in treating a range of conditions

including respiratory

gastrointestinal

and skin disorders. This paper reviews rele

vant literature on glycyrrhiza from recent years and provides a systematic summary of its chemical constituents

pharmacological actions

and clinical applications

aiming to facilitate further basic research and industrial development of this herb.

关键词

Keywords

references

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Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Institute of Spleen and Stomach Diseases， Shanghai University of Traditional Chinese Medicine

Institute of Liver Diseases,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

MOE Key Laboratory for Standardization of Chinese Medicines and SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines,Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine,Shanghai R&D Center for Standardization of Chinese Medicines

College of Business Administration,Jilin Engineering Normal University

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