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湖南中医药大学针灸推拿与康复学院(湖南 长沙 410208)
唐玥,女,硕士研究生,主要从事针灸作用机制的研究工作
郁洁,副教授,硕士研究生导师;E-mail: 4706063@qq.com
收稿:2025-04-08,
纸质出版:2025-11-10
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唐玥,陆梦,车宏,等.针刺治疗心肌缺血再灌注损伤的机制:聚焦神经⁃内分泌⁃免疫网络交互作用[J].上海中医药杂志,2025,59(11):9-16.
TANG Yue,LU Meng,CHE Hong,et al.Mechanism of acupuncture in treating myocardial ischemia reperfusion injury: focusing on neuro⁃endocrine⁃immune network interactions[J].Shanghai Journal of Traditional Chinese Medicine,2025,59(11):9-16.
唐玥,陆梦,车宏,等.针刺治疗心肌缺血再灌注损伤的机制:聚焦神经⁃内分泌⁃免疫网络交互作用[J].上海中医药杂志,2025,59(11):9-16. DOI: 10.16305/j.1007-1334.2025.z20250408001.
TANG Yue,LU Meng,CHE Hong,et al.Mechanism of acupuncture in treating myocardial ischemia reperfusion injury: focusing on neuro⁃endocrine⁃immune network interactions[J].Shanghai Journal of Traditional Chinese Medicine,2025,59(11):9-16. DOI: 10.16305/j.1007-1334.2025.z20250408001.
针刺防治心肌缺血再灌注损伤(MIRI)的机制与其激活神经-内分泌-免疫(NEI)网络密切相关。该网络通过神经递质、激素和免疫因子介导系统间交互,协同调控心脏。通过针刺激发NEI级联反应,在穴位局部产生生物学响应,以NEI网络为枢纽实现系统性调控效应,最终改善MIRI病理进程。聚焦MIRI的针刺干预,分别从神经信号传导、内分泌激素调控和免疫调节3个维度解析其作用路径,并基于NEI网络整体观,阐释针刺多靶点调节MIRI的分子机制,为深入理解其作用原理提供思路。
The mechanism by which acupuncture prevents and treats myocardial ischemia reperfusion injury (MIRI) is closely related to its activation of the neuro-endocrine-immune (NEI) network. This network mediates inter-system communication via neurotransmitters, hormones, and immune factors, coordinately regulates cardiac function. Acupuncture triggers NEI cascade reactions, which generates local biological responses at acupoints. Using the NEI network as a hub, acupuncture achieves systemic regulatory effects, ultimately ameliorating the pathological progression of MIRI. This study focuses on the acupuncture intervention for MIRI. It analyzes its pathways of action from three dimensions: neural signaling pathways, endocrine hormonal regulation, and immune modulation. Furthermore, based on the holistic concept of the NEI network, it elucidates the molecular mechanisms underlying acupuncture's multi-target modulation of MIRI, providing insights for a deeper understanding of its therapeutic principles.
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