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1.天津中医药大学第一附属医院肾内科(天津 300380)
2.国家中医针灸临床医学研究中心(天津 300380)
路晓洁,女,硕士研究生,医师,主要从事中医药治疗肾脏病的研究工作
杨波,主任医师,博士研究生导师;E-mail: yb8203@126.com
收稿:2025-01-14,
纸质出版:2025-12-10
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路晓洁,赵悦彤,吴爽,等.中医药调控肠道微生物干预高尿酸血症的研究进展[J].上海中医药杂志,2025,59(12):103-110.
LU Xiaojie,ZHAO Yuetong,WU Shuang,et al.Research progress on regulation of intestinal microbiota by traditional Chinese medicine in intervention of hyperuricemia[J].Shanghai Journal of Traditional Chinese Medicine,2025,59(12):103-110.
路晓洁,赵悦彤,吴爽,等.中医药调控肠道微生物干预高尿酸血症的研究进展[J].上海中医药杂志,2025,59(12):103-110. DOI: 10.16305/j.1007-1334.2025.z20250114003.
LU Xiaojie,ZHAO Yuetong,WU Shuang,et al.Research progress on regulation of intestinal microbiota by traditional Chinese medicine in intervention of hyperuricemia[J].Shanghai Journal of Traditional Chinese Medicine,2025,59(12):103-110. DOI: 10.16305/j.1007-1334.2025.z20250114003.
高尿酸血症是一种代谢性疾病,中医认为其病机与肝、脾、肾有关,并与肠道微生物群落失衡密切相关。肠道微生物通过多种途径影响尿酸代谢。基于此,中医采用多种方法调节肠道微生物,以治疗高尿酸血症。这些方法安全有效,为高尿酸血症的防治提供了新思路。然而,仍需进一步研究临床转化、个体化治疗和长期安全性等问题。综述中医药调控肠道微生物干预高尿酸血症的研究进展,旨在为中医药防治高尿酸血症的应用提供参考。
Hyperuricemia (HUA) is a metabolic disease. According to traditional Chinese medicine (TCM) theory, its pathogenesis is closely linked to dysfunction of the liver, spleen, and kidneys, as well as an imbalance in the intestinal microbiota. The intestinal microbiota influence uric acid metabolism via multiple pathways. Based on this understanding, TCM utilizes various approaches to modulate the intestinal microbiota to treat HUA. These methods are characterized by their safety and efficacy, offering novel insights into preventing and treating HUA. Nevertheless, further investigation is warranted regarding issues such as clinical translation, personalized treatment strategies, and long-term safety. This article reviews the research progress of TCM regulating intestinal microflora to intervene HUA, in order to provide reference for the application of TCM in the prevention and treatment of HUA.
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