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1.福建中医药大学(福建 福州 350122)
2.福建中医药大学附属第二人民医院(福建 福州 350001)
林锦文,男,硕士研究生,主要从事针推效应评价及作用机制的研究工作
林栋,教授,博士研究生导师;E-mail:bluelike1@ sina.com
收稿日期:2024-06-28,
纸质出版日期:2025-03-10
移动端阅览
林锦文,齐诗仪,王世豪,等.基于眼电信号关联维数特征探讨针灸“治神”对得气针感的影响[J].上海中医药杂志,2025,59(3):12-17.
LIN Jinwen,QI Shiyi,WANG Shihao,et al.Exploring effect of acupuncture "treating the spirit" on sensation of Deqi based on correlation dimension characteristics of electrooculogram signals[J].Shanghai Journal of Traditional Chinese Medicine,2025,59(3):12-17.
林锦文,齐诗仪,王世豪,等.基于眼电信号关联维数特征探讨针灸“治神”对得气针感的影响[J].上海中医药杂志,2025,59(3):12-17. DOI: 10.16305/j.1007-1334.2025.z20240628004.
LIN Jinwen,QI Shiyi,WANG Shihao,et al.Exploring effect of acupuncture "treating the spirit" on sensation of Deqi based on correlation dimension characteristics of electrooculogram signals[J].Shanghai Journal of Traditional Chinese Medicine,2025,59(3):12-17. DOI: 10.16305/j.1007-1334.2025.z20240628004.
目的
2
基于眼电信号关联维数(D
2
)特征探讨得气针感在不同关注状态下针刺的表现形式、关注状态与得气针感强度的关系等,以期为针刺“治神”与得气理论提供科学依据。
方法
2
50例健康受试者以相同顺序依次接受3种关注状态下的足三里穴针刺,每次干预间隔7 d洗脱期。运用自主研发装置和中文改进版马萨诸塞医院针刺感觉量表(C-MMASS)采集眼电信号和得气针感,比较3种关注状态下得气针感强度、眼电信号D
2
以及二者间的相关性,利用受试者操作特征(ROC)曲线评估D
2
对得气结局的预测价值。
结果
2
①关注状态Ⅰ的马萨诸塞医院针刺感觉量表(MASS)指数、酸感、胀感显著高于关注状态Ⅱ(
P
<
0.05)及关注状态Ⅲ(
P
<
0.05),跳动感及其他针感
在关注状态Ⅰ中显著高于关注状态Ⅲ(
P
<
0.05)。轮廓分析显示,酸感、麻感、胀感、沉重感在3种关注状态下总体轮廓相互平行(
F
=0.916,
P
=0.484
>
0.05),不同状态间轮廓没有重合(
F
=5.804,
P
<
0.01);痛感、压迫感、钝痛感、刺感在3种关注状态下总体轮廓相互平行(
F
=0.608,
P
=0.484
>
0.05),不同状态间轮廓重合(
F
=10.812,
P
>
0.05)。②关注状态Ⅰ中D
2
显著低于关注状态Ⅱ(
P
<
0.05)及关注状态Ⅲ(
P
<
0.05),同时关注状态Ⅱ中D
2
也显著低于关注状态Ⅲ(
P
<
0.05)。③相关性分析显示,酸感(
P
<
0.01,
r
=-0.31)、刺感(
P
<
0.05,
r
=-0.19)、麻感(
P
<
0.05,
r
=-0.17)分别与D
2
存在低等程度负相关关系;胀感(
P
<
0.01,
r
=-0.43)、MASS指数(
P
<
0.01,
r
=-0.41)分别与D
2
呈现中等程度负相关关系。④D
2
预测得气结局的ROC曲线下面积(AUC)为0.804,D
2
=1.90为预测得气的临界值,灵敏度为85.2%,特异性为64.3%。
结论
2
得气针感的提高可能与受试者注意力专注于针刺全过程的“治神”状态有关;而采用眼电信号D
2
特征对得气结局进行预测具有可行性及较好的预测性能,有望成为临床医者研判“得气”的新方法。
Objective
2
To explore the manifestations of Deqi needling sensation under different attention states, and the relationship between attention states and the intensity of Deqi based on the correlation dimension (D
2
) characteristics of electrooculogram (EOG) signals, in order to provide scientific evidence for the theories of "treating the spirit" and Deqi in acupuncture.
Methods
2
In this study, 50 healthy participants underwent acupuncture at the Zusanli (ST36) point under three different attention states, with a 7-day washout period between each intervention. EOG signals and Deqi sensations were recorded using a self-developed device and the Chinese modified version of the Massachusetts General Hospital Acupuncture Sensation Scale (C-MMASS).The intensity of the Deqi sensations and the EOG signals D
2
under th
e three attention states, and correlation analysis between the two were compared. The ROC curve was used to evaluate the predictive value of D
2
for the outcome of Deqi.
Results
2
①The MASS index, soreness, and fullness sensations in attention state Ⅰ were significantly higher than those in state Ⅱ(
P
<
0.05) and state Ⅲ(
P
<
0.05). Throbbing and other needling sensations were significantly higher in attention state I than in state Ⅲ(
P
<
0.05). The contour analysis showed that the sensations of soreness, numbness, fullness, and heaviness exhibited parallel contours across the three attention states (
F
=0.916,
P
=0.484
>
0.05), with no overlap between states (
F
=5.804,
P
<
0.01). Pain, pressure, dull pain, and tingling sensations also showed parallel contours across the three attention states (
F
=0.608,
P
=0.484
>
0.05), with overlapping contours between states (
F
=10.812,
P
>
0.05). ②In attention state Ⅰ, D
2
level was significantly lower than that in state Ⅱ(
P
<
0.05) and state Ⅲ (
P
<
0.05), and D
2
level in attention state Ⅱ was also significantly lower than that in state Ⅲ(
P
<
0.05). ③Correlation analysis showed a weak negative correlation between D
2
and sensations of soreness (
P
<
0.01,
r
=-0.31), tingling (
P
<
0.05,
r
=-0.19), and numbness (
P
<
0.05,
r
=-0.17). A moderate negative correlation was found between D
2
and the sensations of fullness (
P
<
0.01,
r
=-0.43), and the MASS index (
P
<
0.01,
r
=-0.41). ④The area under the ROC curve (AUC) of D
2
for predicting outcomes of Deqi was 0.804, with a critical D
2
value of 1.90 as the threshold for Deqi prediction. The sensitivity was 85.2%, and the specificity was 64.3%.
Conclusions
2
The improvement in Deqi sensation may be related to the participants' attention being focused on the "treating the spirit" state throughout the acupuncture process. Additionally, using D
2
characteristics of EOG signals to predict Deqi outcomes is feasible and demonstrates good predictive performance, offering a potential new method for clinicians to assess "Deqi".
林驰 , 王培 , 吴桂雯 , 等 . 初探得气对健康受试者体感诱发电位的影响 [J]. 中华中医药杂志 , 2015 , 30 ( 5 ): 1651 - 1656 .
辛思源 , 李春华 , 刘玉祁 , 等 . 关于影响针刺得气的干预因素研究综述 [J]. 针灸临床杂志 , 2012 , 28 ( 12 ): 58 - 60 .
常晓波 , 樊小农 , 王舒 , 等 . “针刺量学”研究之探本溯源 [J]. 中医杂志 , 2011 , 52 ( 5 ): 363 - 366 .
严世芸 , 李其忠 . 新编简明中医辞典 [M]. 北京 : 人民卫生出版社 , 2007 .
许磊 , 王渊 . 针灸治神与心理正念关系探究 [C]//中国针灸学会. 2022年中国针灸学会年会论文集 . 济南 : 中国针灸学会工作组 , 2022 : 583 - 586 .
章思佳 . 基于眼电生物反馈技术调控经皮穴位电刺激治疗精神发育迟滞儿童的临床研究 [D]. 福州 : 福建中医药大学 , 2022 .
QI S Y , ZHANG S J , LIN L L , et al . Quantifying attention in children with intellectual and developmental disabilities through multicenter electrooculogram signal analysis [J]. Sci Rep , 2024 , 14 ( 1 ): 22186 .
国家市场监督管理总局 , 中国国家标准化管理委员会 . 经穴名称与定位 : GB/T 12346—2021 [S]. 北京 : 中国标准出版社 , 2021 .
YU D T , JONES A Y , PANG M Y . Development and validation of the Chinese version of the Massachusetts General Hospital Acupuncture Sensation Scale: an exploratory and methodological study [J]. Acupunct Med , 2012 , 30 ( 3 ): 214 - 221 .
KONG J , GOLLUB R , HUANG T , et al . Acupuncture de qi,from qualitative history to quantitative measurement [J]. J Altern Complement Med , 2007 , 13 ( 10 ): 1059 - 1070 .
胡妮娟 , 林驰 , 张鹏 , 等 . 关于如何进行针刺得气定性定量判断的思考 [J]. 上海针灸杂志 , 2015 , 34 ( 6 ): 493 - 497 .
林栋 , 林丽莉 . 一种眼电信号捡拾与优化分析方法及装置 : CN112932509B [P]. 2022-10-28 .
YUAN D , LI Y , WANG T , et al . A closed-loop electrical stimulation system triggered by EOG for acupuncture therapy [J]. Syst Sci Control Eng , 2020 , 8 ( 1 ): 128 - 140 .
BAREA R , BOQUETE L , ORTEGA S , et al . EOG-based eye movements codification for human computer interaction [J]. Expert Syst Appl , 2012 , 39 ( 3 ): 2677 - 2683 .
GRASSBERGER P , PROCACCIA I . Characterization of strange attractors [J]. Phys Rev Lett , 1983 , 50 ( 5 ): 346 .
付强 , 李晨溪 , 张朝曦 . 关于G-P算法计算混沌关联维的讨论 [J]. 解放军理工大学学报(自然科学版) , 2014 , 15 ( 3 ): 275 - 282 .
王富春 , 岳增辉 . 刺法灸法学 [M]. 北京 : 中国中医药出版社 , 2021 .
林驰 , 马良宵 , 苑鸿雯 , 等 . “得气”“气至”“针感”概念之我见 [J]. 中华中医药杂志 , 2014 , 29 ( 9 ): 2892 - 2895 .
陆凤燕 . 穴区不同组织结构针刺对得气针感的影响及其可能机制初探 [D]. 北京 : 中国中医科学院 , 2020 .
王培 , 辛思源 , 李静 , 等 . 针刺得气影响因素研究概况 [J]. 中医杂志 , 2018 , 59 ( 3 ): 254 - 258 .
周梅 , 罗佳 , 陈日新 . 陈日新教授“艾灸得气”学术思想及其临床应用 [J]. 上海针灸杂志 , 2019 , 38 ( 11 ): 1290 - 1294 .
王文炎 , 陈瑞 , 梁凤霞 . 对“凡刺之真,必先治神”的思考 [J]. 环球中医药 , 2021 , 14 ( 3 ): 474 - 477 .
曹志文 , 刘洁 , 黄红喜 , 等 . 基于《黄帝内经》理论的治神守气思想探析 [J]. 光明中医 , 2023 , 38 ( 5 ): 834 - 837 .
田鸿芳 , 周清辰 , 王雷 , 等 . 浅析“治神”在针灸治疗失眠中的重要性 [J]. 中华中医药杂志 , 2016 , 31 ( 12 ): 4935 - 4937 .
章思佳 , 林栋 , 齐诗仪 , 等 . 基于眼电信号近似熵探讨针灸治神的临床应用 [J]. 中国针灸 , 2023 , 43 ( 1 ): 79 - 82 .
高原 , 李涛 , 杜小正 , 等 . 从中医“神”的角度探讨眼动的应用 [J]. 中华中医药杂志 , 2022 , 37 ( 8 ): 4826 - 4829 .
韩映虹 , 闫国利 . 眼动分析法在学前儿童认知研究中的应用 [J]. 心理科学 , 2010 , 33 ( 1 ): 191 - 193 .
SHO'OURI N . EOG biofeedback protocol based on selecting distinctive features to treat or reduce ADHD symptoms [J]. Biomed Signal Process Control , 2022 , 71 : 102748 .
王侃 . 基于眼电信号的疲劳驾驶检测技术的研究 [D]. 吉林 : 东北电力大学 , 2022 .
解恒革 , 王晓红 , 王鲁宁 . 不同年龄和注意状态对事件相关电位的影响 [J]. 中国临床康复 , 2004 , 8 ( 10 ): 1826 - 1827 .
孟迎芳 , 叶秀敏 , 马慧姣 . 分类学习与混合学习下的注意促进效应比较 [J]. 心理学报 , 2020 , 52 ( 2 ): 139 - 148 .
PASHLER H , BADGIO P C . Visual attention and stimulus identification [J]. J Exp Psychol Hum Percept Perform , 1985 , 11 ( 2 ): 105 - 121 .
VILLEMURE C , SLOTNICK B M , BUSHNELL M C . Effects of odors on pain perception: deciphering the roles of emotion and attention [J]. Pain , 2003 , 106 ( 1-2 ): 101 - 108 .
JAMES J E , HARDARDOTTIR D . Influence of attention focus and trait anxiety on tolerance of acute pain [J]. Br J Health Psychol , 2002 , 7 ( Pt 2 ): 149 - 162 .
梁宁建 . 心理学导论 [M]. 上海 : 华东师范大学出版社 , 2013 .
段多喜 . 针刺得气量表的构建及测评 [D]. 成都 : 成都中医药大学 , 2018 .
宋言壮 , 孙红兵 , 李西亮 , 等 . 自身针感体验研究总结 [J]. 中国针灸 , 2018 , 38 ( 8 ): 853 - 856 .
郭峥嵘 , 钱桂凤 , 潘秋银 , 等 . 机体状态对针刺得气影响的数据挖掘研究 [J]. 华西医学 , 2014 , 29 ( 6 ): 1102 - 1105 .
ROA R Y , MILTNER W H , WEISS T . Pain-induced attention allocation effects versus distraction from pain.Competition over attention resources [J]. Schmerz , 2014 , 28 ( 4 ): 414 - 416 .
肖文迅 , 刘璐 , 赵洛鹏 , 等 . 针刺得气的客观化研究概况 [J]. 中华中医药杂志 , 2021 , 36 ( 12 ): 7216 - 7218 .
高源 , 吴楚婷 , 李铭旸 , 等 . 转化医学视角下针灸治疗原发性痛经的研究现状与思考 [J]. 上海中医药杂志 , 2024 , 58 ( 8 ): 7 - 13 .
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