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黑龙江中医药大学基础医学院(黑龙江 哈尔滨 150040)
姜欢宁,女,硕士研究生,主要从事中医治则治法及中医药防治脑病的研究工作
李全,副教授,硕士研究生导师; E-mail:liquan_hljucm@163.com
收稿日期:2024-06-27,
纸质出版日期:2025-02-10
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姜欢宁,周妍妍,王琪,等.中医药调控铁死亡干预阿尔茨海默病的研究进展[J].上海中医药杂志,2025,59(2):93-101.
JIANG Huanning,ZHOU Yanyan,WANG Qi,et al.Research progress of traditional Chinese medicine regulating ferroptosis in intervention of Alzheimer's disease[J].Shanghai Journal of Traditional Chinese Medicine,2025,59(2):93-101.
姜欢宁,周妍妍,王琪,等.中医药调控铁死亡干预阿尔茨海默病的研究进展[J].上海中医药杂志,2025,59(2):93-101. DOI: 10.16305/j.1007-1334.2025.z20240627006.
JIANG Huanning,ZHOU Yanyan,WANG Qi,et al.Research progress of traditional Chinese medicine regulating ferroptosis in intervention of Alzheimer's disease[J].Shanghai Journal of Traditional Chinese Medicine,2025,59(2):93-101. DOI: 10.16305/j.1007-1334.2025.z20240627006.
综述中医药调控铁死亡干预阿尔茨海默病(AD)的研究进展。研究表明,铁死亡与AD的发生发展密切相关,其机制涉及铁离子代谢异常和脂质过氧化物积累。中医药具有多组分、多靶点的特性,可通过调节铁死亡途径,抑制β淀粉样蛋白沉积、微管相关蛋白tau(tau蛋白)过度磷酸化和脂质过氧化物产生,进而保护神经元,提高学习记忆能力并改善认知功能障碍,为AD的治疗提供新的思路和方法。
Traditional Chinese medicine regulating ferroptosis in intervention of Alzheimer's disease(AD) is reviewed. There is increasing evidence that ferroptosis is closely related to the occurrence and development of AD, and its mechanisms involve abnormal iron ion metabolism and lipid peroxide accumulation, which may further exacerbate neuronal damage and dysfunction. Traditional Chinese medicine has the characteristics of multi-component and multi-target, regulate the ferroptosis pathway, inhibit β-like amyloid deposition, tau protein hyperphosphorylation and lipid peroxide production. In addition, it protects neurons, improves learning and memory ability and cognitive dysfunction. It provides new ideas and methods for the treatment of AD.
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