最新刊期
卷 58 ， 期 11 ， 2024
- 摘要：With the development of electrostimulation technology， electroacupuncture has emerged within the field of acupuncture. Electroacupuncture leverages microcurrent stimulation of acupoints to achieve therapeutic effects and is widely used in clinical practice. However， the lack of clinical operation benchmark has affected its therapeutic efficacy， medical safety， and the reproducibility of treatment outcomes. In light of this， the World Federation of Acupuncture-Moxibustion Societies reviewed， approved， and released the Technical Benchmark of Acupuncture and Moxibustion： Electroacupuncture in 2023， which aims to standardize electroacupuncture procedures and enhance the standardization level of its clinical application. This paper discusses the practical significance and value of the Technical Benchmark of Acupuncture and Moxibustion： Electroacupuncture， reviews the development process， summarizes its characteristics， and shares insights from the development experience.关键词：electroacupuncture;acupuncture and moxibustion;technical benchmark;clinical practice;standardization;internationalization
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发布时间：2024-11-07 - 摘要：ObjectiveTo develop an objective and quantifiable traditional Chinese medicine （TCM） diagnostic tool for spleen qi deficiency， spleen damp-heat， and spleen deficiency with damp-heat syndromes， providing a methodological reference and example for the standardization and quantification of TCM syndromes.MethodsThe study constructed symptom item pools for the three syndromes using literature review， warehouse method， and selection method. The items were then optimized and screened through three rounds of Delphi expert surveys. A combined subjective-objective weighting method was used to assign weights to the items. Finally， the receiver operating characteristic curve （ROC） was constructed using physician diagnostic results as the gold standard， and the Youden index was used to determine the diagnostic thresholds for each syndrome.ResultsA total of 337 symptom items related to spleen qi deficiency， spleen damp-heat， and spleen deficiency with damp-heat syndromes were collected through literature research. After screening and optimization， spleen qi deficiency syndrome included 10 core factors such as poor appetite， lassitude， fatigue， and undigested food in stools； spleen damp-heat syndrome included 11 core factors such as heaviness in the limbs， heartburn， and sticky mouth； and spleen deficiency with damp-heat syndrome included 9 core factors such as lassitude， fatigue， heaviness in the limbs， and sticky mouth. The diagnostic thresholds for the three syndromes were 10 points， 16.5 points， and 12.5 points， respectively.ConclusionThe self-evaluation diagnostic scale for spleen qi deficiency， spleen damp-heat， and spleen deficiency with damp-heat syndromes can assist TCM physicians in clinical syndrome differentiation， and provides a quantifiable TCM diagnostic tool for non-TCM professionals.关键词：traditional Chinese medicine syndrome;standardization;spleen deficiency;spleen damp-heat;spleen deficiency with damp-heat;syndrome differentiation and treatment
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发布时间：2024-11-07 - 摘要：ObjectiveTo investigate the diagnostic experience of experts in identifying the syndrome of liver qi stagnation in psoriasis vulgaris， select diagnostic indicators for this syndrome， evaluate their importance， and establish diagnostic criteria for liver qi stagnation syndrome in psoriasis vulgaris.MethodsBased on literature research， a four-round Delphi survey was conducted with 32 national experts， analyzing the concentration and coordination of expert opinions. In the fourth round， diagnostic indicators were categorized as primary or secondary symptoms based on their weighted importance to form the diagnostic criteria for liver qi stagnation syndrome.ResultsBased on literature research， 27 potential diagnostic entries for the syndrome were initially identified. Based on the concentration and coordination of expert opinions， 19 diagnostic indicators were finalized and categorized into 3 primary and 7 secondary symptoms. There were two diagnostic criteria with high expert recognition.ConclusionsThe enthusiasm and professionalism of the experts were high， credibility of opinions was strong， and the level of coordination was substantial. After four rounds of surveys， diagnostic criteria for liver qi stagnation syndrome in psoriasis vulgaris were established.关键词：psoriasis vulgaris;traditional Chinese medicine syndrome;liver qi stagnation syndrome;diagnostic criteria;Delphi method;traditional Chinese medicine standardization
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发布时间：2024-11-07 - 摘要：ObjectiveTo explore potential subgroups among patients with chronic heart failure （CHF） of qi deficiency and blood stasis syndrome， providing an objective basis for precise traditional Chinese medicine （TCM） diagnosis and treatment of heart failure.MethodsNineteen symptoms/signs and 21 biochemical indicators were collected from 126 patients with CHF of qi deficiency and blood stasis syndrome. The K-medoids clustering algorithm was applied using R and Python software， and the optimal number of clusters was determined via the silhouette coefficient. For intergroup comparisons， continuous variables were analyzed using the Kruskal-Wallis test， and categorical variables were analyzed using Pearson's chi-squared test or Fisher's exact test.ResultsPatients with CHF of qi deficiency and blood stasis syndrome were clustered into three groups. Intergroup comparisons revealed that five symptoms/signs （shortness of breath， insomnia， jugular vein distention， poor appetite， and aversion to cold） and four clinical indicators （NYHA classification， NT-proBNP， hematocrit， and blood urea nitrogen） showed statistical significance （P<0.05）. Group 1 had relatively lower frequencies of symptoms/signs and less severe clinical indicators. Group 2 was characterized by a higher frequency of jugular vein distention compared to other groups， with tendencies toward elevated thyroid-stimulating hormone， total cholesterol， low-density lipoprotein， and decreased platelet counts. Group 3 exhibited significantly higher incidences of aversion to cold， poor appetite， and insomnia， accompanied by increased blood urea nitrogen and decreased hematocrit.ConclusionThree potential subtypes of qi deficiency and blood stasis syndrome in CHF patients have been identified： pure qi deficiency and blood stasis syndrome type， qi deficiency and blood stasis combined with phlegm-dampness type， and qi deficiency and blood stasis combined with yang deficiency type.关键词：chronic heart failure;qi deficiency and blood stasis syndrome;phlegm-dampness;yang deficiency;clustering algorithm;data mining;syndrome differentiation and treatment
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发布时间：2024-11-07 - 摘要：ObjectiveTo analyze the medication patterns of traditional Chinese medicine （TCM） external therapy for migraines based on TCM classics， providing a reference for establishing technical operation standards for the treatment of migraines.MethodsRelevant entries from ancient texts on TCM external therapy for migraines were searched and retrieved. Information on the names of the formulas， ingredients， dosage forms， administration routes， and onset time was extracted， standardized， and entered into a database using Excel. The frequency of the four properties， five flavors， and meridian tropism of the TCM ingredients was analyzed using the TCM inheritance support system V3.0 （TCMISS V3.0）. Additionally， association rule analysis and cluster analysis were performed on the TCM external therapy formulas.Results①A total of 171 external therapy formulas， involving 206 traditional Chinese herbal medicines （TCHMs）， were included， of which 44 were identified as fast-acting. ②The formulas involved six routes of administration： nasal， ocular， aural， oral， dermal， and other routes， with nasal administration being the most frequent （97 instances）. Over ten different dosage forms were identified， including powders， plasters， pastes， fresh herbs， aerosols， and pills， with powders being the most commonly used （74 instances）. ③The distribution of the four properties showed a predominance of warm properties， followed by cold properties； among the distribution of the five flavors， pungent is the most dominant， followed by bitter； the meridian tropism analysis showed a primary focus on the liver meridian， followed by the spleen and heart meridians. ④A total of 15 high-frequency TCHMs were identified， mainly including herbs for relieving exterior syndromes， blood-activating and stasis-dissolving herbs， and orifice-opening herbs. Seven core formula combinations were identified through association rule analysis， and five core herbal clusters were obtained through cluster analysis. ⑤Among the 44 fast-acting formulas， four routes of administration were identified： nasal， aural， ocular， and dermal， involving 11 dosage forms and 71 TCHMs， with nasal administration being the most frequent （27 instances） and powders being the most commonly used （20 instances）. The high-frequency TCHMs primarily included herbs for relieving exterior syndromes and blood-activating and stasis-dissolving herbs.ConclusionThere are many effective TCM external therapy formulas for migraines documented in ancient TCM texts， which hold valuable potential for further exploration. These findings can provide a reference for establishing technical operation standards for the TCM external treatment of migraines.关键词：migraine;traditional Chinese herbal medicines;external therapy;literature research;data mining;medication patterns
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发布时间：2024-11-07 -
Ancient and modern application and key information research of classic famous formula Xiangsu Powder
摘要：The classic famous formula Xiangsu Powder， included in the Catalogue of Ancient Classical Prescriptions （Second Batch）， consists of four herbs： Xiangfu （Cyperi Rhizoma）， Zisuye （Perillae Folium）， Gancao （Glycyrrhizae Radix et Rhizoma） and Chenpi （Citri Reticulatae Pericarpium）. It is traditionally used for treating common colds， epidemic diseases， abdominal pain， headaches， rheumatic pain in the legs， and cold injuries during pregnancy. In modern clinical practice， it is widely used to treat diseases of the digestive， respiratory， and nervous systems. We collected 36 related records from 32 ancient texts， and conducted statistical analysis and processing of the collected data in the study. Furthermore， we reviewed modern research literature to analyze the origins， composition， botanical origins， preparation and processing methods， decoction and administration practices， and clinical applications of Xiangsu Powder. The findings provide a foundation for further research and development of Xiangsu Powder.关键词：classic famous formula;Xiangsu Powder;action and indication;textual research;clinical applications;traditional Chinese herbal medicine research- 4
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发布时间：2024-11-07 - 摘要：Taking "ancient-modern" and "macro-micro" as axes， the system retrieves literature from ancient to modern times. It considers the original dose and ratio of Chaihu Jia Longgu Muli Decoction， reviews the evolution of doses over time， summarizes the characteristics of modern clinical applications， and consolidates the progress of dose-related experimental research. The study shows that the original dose of the formula is approximately 62.5 g of Bupleuri Radix （Chaihu）， 33.5 g of Pinelliae Rhizoma （Banxia）， 31.3 g of Rhei Radix Et Rhizoma （Dahuang）， approximately 23.4 g each of Ossa Draconis （Longgu）， Ostreae Concha （Muli）， Scutellariae Radix （Huangqin）， Zingiberis Rhizoma Recens （Shengjiang）， Plumbum Rubrum （Qiandan）， Ginseng Radix Et Rhizoma （Renshen）， Cinnamomi Ramulus （Guizhi） and Poria （Fuling）， along with 24 g of Jujubae Fructus （Dazao）. The ratio is close to 8∶4∶4∶3∶3∶3∶3∶3∶3∶3∶3∶3. The commonly used modern dose is about half of the original dose， accompanied by a decrease in the proportion of Dahuang and an increase in the proportions of Longgu and Muli. There are significant differences in the usage dosages of Chaihu Jia Longgu Muli Decoction between ancient and modern times. In contemporary clinical practice， it is neither advisable to "blindly follow and adhere rigidly to ancient prescriptions" nor to "make arbitrary modifications and adjustments." Therefore， based on a thorough study of classical texts， it is crucial to "seek the commonalities and discern the differences between ancient and modern times." The modernization research of "ancient prescriptions for modern use" still has a long way to go.关键词：Chaihu Jia Longgu Muli Decoction;classic famous formula;dosage;textual research;literature study
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发布时间：2024-11-07 - 摘要：Feilian， also known as cockroach， is one of the four traditional pests. There are rare reports summarizing its medicinal properties， efficacy and clinical compatibility as a traditional Chinese medicine. Represented by Periplaneta americana， Blattidae insects has a long history of medicinal use and has shown good efficacy in the treatment of many diseases. But other cockroaches， such as the Periplaneta australis and Blatta orientalis， have not been sufficiently emphasized， developed and applied. In order to further develop and apply the medicines of cockroach， it is necessary to know whether they are effective as medicines or not. Therefore， through reviewing a large number of materia medica and medical texts， the medicinal properties， efficacy and clinical application of cockroach were researched， in order to excavate the medicinal value of the harmful insects for the service of human health.关键词：Feilian;cockroach;property;efficacy;clinical application;herbal textual research;traditional Chinese medicine research
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发布时间：2024-11-07 - 摘要：Trichosanthis Fructus， Trichosanthis Semen and Trichosanthis Pericarpium are different parts of the same plant's fruit. In order to understand the application history of the three kinds of drugs and their mutual relations， the textual researches of the medicinal parts， processing methods， medicinal properties and effects of Trichosanthis Fructus， Trichosanthis Semen and Trichosanthis Pericarpium were carried out by systematically consulting the materia medica and medicine books of the past dynasties in this paper. The results showed that the plant name "Trichosanthes kirilowii " was commonly used instead of Trichosanthis Fructus in ancient books of the past dynasties. The different parts were used as medicine， such as fruit， seed， flesh， peel in ancient prescriptions. In ancient times， Trichosanthis Fructus， Trichosanthis Semen or Trichosanthis Pericarpium were processed by stir-frying， stir-frying with clam shell powder or Puerariae Thomsonii Radix powder， burning， calcination， steaming， removing oil， etc. At present， stir-frying and mix-frying with honey are commonly used methods for processes of these three drugs. Its properties and flavor were changed from "bitter， cold" to "sweet， cold". It was not until modern times that the meridian tropism of these three drugs was recorded. The efficacy of Trichosanthis Semen is inclined to moistening the lung and defecate， the efficacy of Trichosanthis Pericarpium is inclined to clearing heat， reducing phlegm， and widening the chest， and the efficacy of Trichosanthis Fructus includes all the above efficacies.关键词：Trichosanthis Fructus;Trichosanthis Semen;Trichosanthis Pericarpium;medicinal parts;processing methods;medicinal properties;efficacy;herbal textual research
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发布时间：2024-11-07 - 摘要：The research strategy of traditional Chinese medicine in Alzheimer's disease（AD） is discussed based on the theory of "turbid evils invading the clear orifice". It is believed that "turbid evils invading the clear orifice" is the core mechanism for the aggravation of the disease in the middle and late stages. It is proposed that deficiency of kidney essence is the basis of pathogenesis， and phlegm and stasis evils obstruction of the orifice is the key link of pathogenesis. Combined with clinical research and Chinese medicine pharmacology research， it is believed that tonifying deficiency and dispelling turbidity is the basic rule of treatment， and it is proposed that on the basis of tonifying the kidney and generating the marrow， the core treatments such as resolving phlegm and opening orifice， activating blood circulation and dispelling blood stasis should be combined.关键词：Alzheimer's disease;turbid evils invading the clear orifice;etiology and pathogenesis;traditional Chinese medicine therapy
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发布时间：2024-11-07 - 摘要：From the perspective of Zangxiang， the concept of "the heart governing the mind" focuses on the functional attributes of the heart， while "the heart governing the blood vessels" focuses on its anatomical attributes. In essence， the heart in traditional Chinese medicine represents an integrated system that combines both functional and anatomical aspects. To elaborate， the anatomical heart"system includes the heart， stomach （including other digestive organs） and brain， which serve as the material base of the spirit. And the functional heart system includes the brain and stomach （as well as other digestive organs like the gallbladder）， which manifest the function of the spirit. Anyway， considering all aspects， the brain serves as the ultimate conductor of internal organs that actually govern the mind， which is "single-minded".关键词：heart;heart's governing of mental and emotional activities;brain;functional viscera;anatomic viscera;mental disorder;traditional Chinese medicine theory
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发布时间：2024-11-07 - 摘要：Polycystic ovary syndrome （PCOS） is a complex reproductive metabolic disorder with a genetic predisposition， and its related symptoms can be transmitted across generations. Latent pathogens in traditional Chinese medicine （TCM） are considered as pathogenic factors that lie dormant within the body and do not immediately cause diseases， bearing similarities to the mechanisms of intergenerational effects observed in PCOS. Integrating the theory of latent pathogens from TCM with modern medical understandings of mechanisms of PCOS's intergenerational effects offers new insights for the early recognition and treatment of PCOS in TCM practice.关键词：polycystic ovary syndrome;theory of latent pathogens;intergenerational effect;traditional Chinese medicine theory;traditional Chinese medicine therapy
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发布时间：2024-11-07 - 摘要：This paper introduces the clinical experience of Director Chen Jing， the fifth generation inheritor of Zhu's gynaecology， in treating infertility caused by polycystic ovary syndrome （PCOS） based on the theory of "dredging reproductive axis and regulating Shen". She believes that the pathogenesis of infertility in PCOS is due to the blockage of tangible pathogens such as phlegm， dampness， and blood stasis in the＂kidney- Tiangui - thoroughfare and conception channels-uterus "reproductive axis， causing the Tiangui to be unable to travel smoothly in the two meridians of the thoroughfare and conception channels， resulting in a true excess disease with false deficient manifestation of infertility sign. The treatment should be formulated to dissolve phlegm， regulating the spleen， dispersing the stagnated liver qi and regulating the thoroughfare channels， dredging collaterals and removing blood stasis， and the method of regulating the spirit should be carried out throughout the treatment. In addition， acupuncture and moxibustion therapy and life intervention are used as auxiliary treatments. And a proven case is presented.关键词：polycystic ovary syndrome;infertility;dredging reproductive axis and regulating spirit;combination of acupuncture and medicine;expert experience
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发布时间：2024-11-07 - 摘要：This paper discusses the application of Red Ginseng Er Zhi Formula in the treatment of erectile dysfunction. The erectile dysfunction is caused by yin deficiency and blood stasis， resulting in the loss of nourishment of the penis， which is manifested as a syndrome of kidney deficiency and blood stasis. Referring to the medication concept of "brain-heart-kidney-essence chamber" axis， we analyze the clinical experience and perspectives of Red Ginseng Er Zhi Formula in the treatment of erectile dysfunction. One proven case is presented.关键词：impotence;erectile dysfunction;"brain-heart-kidney-essence chambe" axis;Red Ginseng Er Zhi Formula;traditional Chinese medicine therapy;clinical application
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发布时间：2024-11-07 - 摘要：Based on the theory of "treating blood before wind"， Professor Bai Yanping's experience in treating pruritus is discussed. In clinical diagnosis and treatment， Professor Bai often focuses on differentiating wind and blood syndrome. From the causes of disease， etiology and treatment and medication methods， we can see the application of the method of "treating blood before wind". Two proven cases are presented.关键词：skin disease;pruritus;neurodermatitis;atopic dermatitis;treating blood before wind;traditional Chinese medicine therapy;expert experience
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发布时间：2024-11-07 - 摘要：ObjectiveTo construct an efficacy evaluation model for common traditional Chinese medicine （TCM） syndromes of chronic insomnia based on deep features of tongue images.MethodsBased on the tongue images of 220 healthy controls， the deep convolutional neural network （ResNet50） was used to conduct binary classification learning on the tongue images of 241 patients with chronic insomnia of phlegm-heat disturbing the heart syndrome， 185 patients with heart-spleen deficiency syndrome， and 266 patients with heart-kidney non-interaction syndrome. Three different benchmark models with a classification accuracy of more than 95% in the verification set were obtained. After fixing their parameters， the images before and after TCM treatment were input into the model respectively to obtain the corresponding probability output， that is， the health likelihood of the case before and after treatment， and analysis was carried out.ResultsDuring the treatment period， the health likelihood of tongue image features of effective cases of TCM treatment for different syndromes of chronic insomnia showed a linear increasing trend； the change of health likelihood of tongue image features of ineffective cases of TCM treatment was related to TCM syndromes， showing a linear decreasing trend （phlegm-heat disturbing the heart syndrome）， first increasing and then decreasing to the pre-treatment level （heart-spleen deficiency syndrome）， and a slow increasing trend （heart-kidney non-interaction syndrome）， respectively.ConclusionThe efficacy evaluation method and visual presentation of treatment for chronic insomnia based on deep features of tongue images have good objectivity and readability.关键词：chronic insomnia;efficacy evaluation;tongue image features;deep neural network;deep learning;traditional Chinese medicine diagnosis;artificial intelligence
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发布时间：2024-11-07 - 摘要：ObjectiveTo investigate the effects of polysaccharides from Endothelium Corneum Gigeriae Galli （PECG）on the activity of islet β cells induced by high glucose， superoxide dismutase （SOD）， malondialdehyde （MDA） and nuclear factor E2 related factor 2 （Nrf2）.MethodsIslet β cells MIN6 were cultured to detect their activity and then divided into normal group （5.5 mmol·L-1 normal glucose treatmentfor for 4 h） and high glucose group （high lipid and high glucose treatment for 1 h， 33.3 mmol·L-1 glucose +0.25 mmol·L-1 palmitic acid）， low dose of PECG （20 μmol·L-1 PECG pretreatment for 4 h+ high fat and high sugar treatment for 24 h）， high dose of PECG （80 μmol·L-1 PECG pretreatment for 4 h+ high fat and high sugar treatment for 24 h）， cell proliferation rate was detected by 5-acetylidene-2' deoxyuracil ribonucleoside （EdU）， apoptosis was detected by notch end labeling （TUNEL）， cell cycle was analyzed， and migration function of MIN6 cells was detected by cell scratch assay. The levels of SOD and MDA in MIN6 cell culture medium were detected， and the protein expressions of Nrf2， quinone oxidoreductase 1 （NQO1） and heme monooxygenase-1 （HO-1） in MIN6 cells were detected by Western blot. Real-time fluorescence quantitative reverse transcription polymerase chain reaction （RT-qPCR） was used to detect Nrf2， HO⁃1 and NQO1 mRNA expression in MIN6 cells.ResultsCompared with the normal group， the high-glucose group showed decreased cell proliferation of MIN6 cells， as well as reduced levels of SOD and decreased expression of Nrf2， HO-1， and NQO1 mRNA and proteins. Additionally， there were increases in MDA levels and cell apoptosis （P<0.05）. Relative to the high-glucose group， the low-dose PECG group showed higher proliferation of MIN6 cells and elevated levels of SOD， as well as increased expression of Nrf2， HO-1， and NQO1 mRNA and proteins. It also showed lower MDA levels and reduced cell apoptosis （P<0.05）. Compared with the low-dose PECG group， the high-dose PECG group showed increased proliferation of MIN6 cells， elevated levels of SOD， and increased expression of Nrf2， HO-1， and NQO1 mRNA and proteins. There were reductions in MDA levels and cell apoptosis （P<0.05）. Compared with the normal group， the high-glucose group showed an increased G0/G1 phase and decreased S and G2/M phases in the cell cycle of MIN6 cells （P<0.05）. Compared with the high-glucose group， the low-dose PECG group showed a decrease in the G0/G1 phase and increases in the S and G2/M phases （P<0.05）. Compared with the low-dose PECG group， the high-dose PECG group showed further reductions in the G0/G1 phase and increases in the S and G2/M phases （P<0.05）. The scratch assay results revealed no differences in the gap area at 0 h among all groups. However， at 24 h， the gap area in the high-glucose group increased， whereas it decreased in the low-dose PECG group and was significantly narrowed in the high-dose PECG group.ConclusionPECG can promote the proliferation of MIN6 islet β cells and inhibit their apoptosis， and the effect is likely associated with the suppression of the Nrf2 signaling pathway and related pathways.关键词：diabetes mellitus;polysaccharides from Endothelium Corneum Gigeriae Galli （PECG）;islet β cell;nuclear factor E2-related factor （Nrf2）;mechanism of action;traditional Chinese herbal medicine research
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发布时间：2024-11-07 - 摘要：This review discusses the advancements in research on interventions using traditional Chinese herbal medicine （TCHM） for ischemic stroke through the RhoA/Rho-associated coiled-coil containing protein kinase （ROCK） signaling pathway. The RhoA/ROCK pathway plays a crucial role in the pathological process of ischemic stroke， primarily involving cellular apoptosis， excitotoxicity， neuroinflammation， the blood-brain barrier， and neural function. Various TCHM compound formulas and its active ingredients regulate the RhoA/ROCK signaling pathway and the expression of its upstream and downstream target genes to reduce neuronal apoptosis， alleviate inflammatory responses， decrease the size of cerebral infarctions， protect the blood-brain barrier， and promote synaptic repair and regeneration. These findings provide new insights for the study of mechanisms underlying TCHM treatments for ischemic stroke and the development of novel therapeutic targets.关键词：ischemic stroke;RhoA/ROCK signaling pathway;traditional Chinese herbal medicine;mechanisms of action;research progress
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发布时间：2024-11-07
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