最新刊期
卷 58 ， 期 10 ， 2024
- 摘要：Depression syndrome is a condition with a high incidence rate and complex etiology and pathogenesis. Yan Shiyun， a national master of traditional Chinese medicine （TCM）， approaches the treatment of depression syndrome from the perspective of TCM principles， specifically the concept of "seeking harmony through changes". He advocates for a comprehensive consideration of qi and blood， yin and yang， organs and emotions， aiming to understand the root causes and pathogeneses of the disease. His approach features a distinctive strategy in prescription and medication， emphasizing the prioritization of qi and blood， the mutual support of yin and yang， the coordinated adjustment of organs， and the simultaneous treatment of body and mind， and ultimately aiming to achieve overall harmony through adaption to changes. Two proven cases are included for illustration.关键词：depression syndrome;depression;seeking harmony through changes;traditional Chinese medicine therapy;famous doctor's experience
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发布时间：2024-09-30 - 摘要：In recent years， there has been a surge of interest in the research on the intelligentization of traditional Chinese medicine （TCM） diagnostics， with intelligent pulse diagnosis being a focal point. The intelligentization of pulse diagnosis primarily focuses on pulse acquisition and data processing. The challenges in pulse acquisition mainly lie in sensors and pulse acquisition tools， and there is currently no unified industry standard for data sources or processing methods. Present research predominantly focuses on pulse waveform variations and radial artery ultrasound data. This paper introduces data annotation methods based on the eight key elements of pulse diagnosis （pulse position， pulse strength， pulse beats， pulse rhythm， pulse length， pulse width， fluency and tension）， compares the advantages and disadvantages of pulse waveform and radial artery ultrasound， and explores the feasibility of using three-dimensional pulse waveforms as a form of pulse diagnosis data annotation. It further discusses the current front-end processing methods for pulse waveforms and the application of artificial intelligence and machine learning in pulse waveform data annotation， aiming to provide new research perspectives for the objectification of pulse diagnosis.关键词：traditional Chinese medicine diagnosis;artificial intelligence;pulse diagnosis devices;intelligent equipment;algorithm models
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发布时间：2024-09-30 - 摘要：Kongsheng Zhenzhong Dan is a classic famous formula commonly used in the clinical practice of treating encephalopathy. This paper investigates its name， composition， dosage， preparation methods， medicinal origins， therapeutic effects， primary indications and clinical applications. The earliest record of Kongsheng Zhenzhong Dan can be found in the Jiyan Fang （A Collection of Proven Formulas）. Despite the various names it has been known by， most names emphasize the concept of "Yizhi （enhancing intelligence）" except for Guijia San. The recommended formulation includes 1.25 grams each of Guijia （Testudinis Carapax et Plastrum）， Longgu （Fossilia Ossis Mastodi）， Shichangpu （Acori Tatarinowii Rhizoma）， and Yuanzhi （Polygalae Radix）， all ground into a fine powder. It is suggested to take 5 grams of the powder with warm rice wine， three times a day. The formula calms the heart， tranquilizes the spirit， nourishes the kidneys， strengthens the brain， and harmonizes the heart and kidneys. Historically and currently， its applications focus on neurological conditions such as amnesia and insomnia. Notably， it has shown unique advantages in treating neurodevelopmental disorders in children.关键词：classic famous formula;Kongsheng Zhenzhong Dan;insomnia;amnesia;historical evolution;textual research
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发布时间：2024-09-30 - 摘要：By systematically reviewing ancient literatures across various eras， this study traces and analyzes the historical evolution and key information of Guizhi Gancao Decoction from seven perspectives： the origin and historical development of the formula， the name and composition of the formula， historical medical commentaries and theoretical analysis， efficacy and indications， raw materials and processing methods， dosage， and preparation and administration methods. This analysis aims to provide a theoretical basis for the development and application of the classic famous formula Guizhi Gancao Decoction.关键词：classic famous formula;Guizhi Gancao Decoction;cardiovascular disease;historical evolution;efficacy and indications;textual research
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发布时间：2024-09-30 - 摘要：Shaoyao Tang was first documented by Jin dynasty scholar Liu Wansu in his work， Suwen Bingji Qiyi Baoming Ji （Collection on the Essential Questions of Disease Mechanisms and Qi Management for Preserving Life）， and it is also listed in the Catalogue of Ancient Classic Formulas （Second Batch） - Han Chinese Medicine， published by the National Administration of Traditional Chinese Medicine. Shaoyao Tang is composed of nine traditional Chinese medicinal herbs： Baishao （Paeoniae Radix Alba）， Danggui （Angelicae Sinensis Radix）， Huanglian （Coptidis Rhizoma）， Binglang （Arecae Semen）， Muxiang （Aucklandiae Radix）， Gancao （Glycyrrhizae Radix et Rhizoma）， Dahuang （Rhei Radix et Rhizoma）， Huangqin （Scutellariae Radix）， and Guangui （Cinnamomi Cortex）. The study employed bibliometric methods to examine and analyze the classical formula Shaoyao Tang from various aspects， including historical origin， prescription composition and dosage， medicinal basis and processing， decoction and administration method， therapeutic efficacy and primary indications， and modern clinical applications. After screening， the study included 51 ancient prescriptions that clearly documented the composition of Shaoyao Tang， 38 of which contained complete information on dosages ，decoction and administration methods. Additionally， 228 modern clinical studies on the use of Shaoyao Tang for treating diseases were incorporated into the research. Upon thorough analysis， the study recommends a modern dosage of Shaoyao Tang at 20.65 g per dose， consisting of 5.82 g of Baishao， 2.91 g each of Danggui， Huanglian， Huangqin， 1.75 g of Dahuang， 1.16 g each of Binglang， Muxiang， Gancao， and 0.87 g of Rougui. These herbs are to be coarsely ground and decocted with 600 mL of water until reduced to 300 mL. After removing the residue， the decoction should be taken warm after meals， three times a day. Shaoyao Tang is effective in clearing heat， promoting diuresis， regulating qi， and harmonizing blood. It is a classic traditional Chinese medicine prescription for treating damp-heat dysentery. In modern clinical practice， it is frequently used to treat gastrointestinal diseases such as ulcerative colitis， bacterial dysentery， and radiation-induced rectal damage.关键词：classic famous formula;Shaoyao Tang;literature research;clinical application;therapeutic efficacy and primary indications;traditional Chinese herbal medicine research
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发布时间：2024-09-30 - 摘要：ObjectiveTo investigate the distribution characteristics of traditional Chinese medicine （TCM） syndromes in patients with prostate cancer， providing reference for TCM treatment of prostate cancer.MethodsTCM four diagnostic information of 228 prostate cancer patients was collected. Principal component analysis was used for factor analysis of selected items. The characteristics of TCM syndrome elements in prostate cancer were determined based on syndrome element determination criteria. Systematic cluster analysis was then applied to the items to explore the distribution pattern of TCM syndromes in prostate cancer.Results①The top ten symptoms and signs were frequent urination， tidal fever with night sweats， dry stools， lumbar and knee soreness， dizziness， urgent urination， aversion to cold with cold limbs， fatigue， insomnia， and constipation. ②Cluster analysis showed that the most common TCM syndrome in prostate cancer was spleen-kidney deficiency syndrome （29.82%）， followed by kidney deficiency with static blockage syndrome （21.49%）， qi-yin deficiency syndrome （20.61%）， qi-blood deficiency syndrome （20.18%）， and qi stagnation and blood stasis syndrome （7.89%）. ③Factor analysis results showed that the pathogenic syndrome elements of prostate cancer included qi deficiency， yang deficiency， yin deficiency， blood stasis， blood deficiency， and damp-heat， while the affected organs were the kidney， spleen， liver， brain， and heart.ConclusionProstate cancer involves the kidney， spleen， liver， brain， and heart， often presenting with mixed deficiency and excess syndromes. Clinically， it can be categorized into spleen-kidney deficiency syndrome， kidney deficiency with static blockage syndrome， qi-yin deficiency syndrome， qi-blood deficiency syndrome， and qi stagnation and blood stasis syndrome， with spleen-kidney deficiency being the most prevalent.关键词：prostate cancer;traditional Chinese medicine syndrome elements;traditional Chinese medicine syndromes;cluster analysis;factor analysis
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发布时间：2024-09-30 - 摘要：By expounding the reverse and forward transmission pattern of pulmonary epidemic diseases， we propose a three-stage progression pattern： the latent period （pre-disease）， the onset period （forward transmission， and reverse transmission）， and the convalescence period （prolongation， neopathy， and recovery）. Considering the pathogenesis progression of SARS-CoV-2 infection， our focus lies on staging and syndrome-based prevention and treatment of pulmonary epidemic diseases. Strategies for prevention and treatment of SARS-CoV-2 infection are suggested， including prevention prior to infection， prevention of reverse transmission during infection， and prevention of neopathies after recovery. The aim is to provide theoretical support for potential future pulmonary epidemic diseases and further guide clinical practice.关键词：pulmonary epidemic diseases;SARS-CoV-2 infection;reverse and forward transmission pattern;prevention and treatment strategies;traditional Chinese medicine therapy
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发布时间：2024-09-30 - 摘要：This paper summarizs the clinical experience of professor Tan Xinhua in treating male infertility with seed Chinese medicine. Professor Tan points out that some seed Chinese medicines are in connection with male reproduction，which is suitable for male infertility caused by abnormal semen quality or sexual dysfunction. He thinks that the seed Chinese medicine with the functions of invigorating kidney and producing essence， invigorating spleen and stomach and transporting dampness，soothing liver and regulating qi and promoting blood can effectively improve semen quality. The seed Chinese medicine with the effect of warming kidney yang and consolidating kidney qi can effectively enhance sexual function. When used properly， it is hoped that infertile men will regain the ability to reproduce normally. One proven case is presented.关键词：male infertility;seed Chinese medicine;experience of famous doctors;traditional Chinese medicine therapy
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发布时间：2024-09-30 - 摘要：Lumbar disc herniation is a common and frequently occurring disease in modern society. Based on the technological achievements of "921 Zhentong Gao （921 Analgesic Ointment）"， Professor Qiu Zuping proposes a comprehensive triple therapy specifically for lumbar disc herniation， which combines acupoint-targeted injection， transdermal herbal application， and internal herbal decoction. The triple therapy has shown remarkable efficacy. A proven case is provided.关键词：lumbar disc herniation;Bi syndrome;921 Zhentong Gao （921 Analgesic Ointment）;acupoint injection;traditional Chinese medicine therapy;famous doctor's experience
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发布时间：2024-09-30 - 摘要：This article introduces Professor Zhan Libin's application of the theory of "removing the earth stagnation"， discussing the close relationship between "earth stagnation" and the pathogenesis of depression from the perspectives of "spleen deficiency causing soil depression"， "water invasion invading soil depression"， "liver wood riding on soil depression"， and "fire does not generate soil depression". It summarizes the principles commonly used by Professor Zhan in clinical practice to treat depression， such as "strengthening the spleen and promoting clarity to remove it"， "promoting water and eliminating dampness to remove it"， "relieving liver wood to remove it"， and "nourishing fire and supplementing soil to remove it". Professor Zhan is good at "relieving" and "guiding" depression patients in clinical practice， and uses language to guide them， achieving a good therapeutic effect of "treating depression with both body and mind". And a proven case is presented.关键词：depression;removing the earth stagnation;experience of famous doctor;traditional Chinese medicine therapy
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发布时间：2024-09-30 - 摘要：The core pathogenesis of metabolic associated fatty liver disease （MAFLD） is deficiency in the root and excess in manifestations. The root deficiency pertains to deficiency of the liver， spleen， and kidneys， while the excess in manifestations is predominantly marked by phlegm， dampness， stasis， and heat， often presenting as damp-heat accumulation syndrome clinically. Tufuling （Smilacis Glabrae Rhizoma） and Shengtoucao （Melilotus Suaveolens Ledeb） are frequently used in combination to treat damp-heat accumulation syndrome in MAFLD. This herbal pair addresses both internal and external factors， and treat the upper， middle， and lower energizers simultaneously， effectively clearing phlegm， dampness， and filthy turbidity， while also strengthening the spleen and harmonizing the middle energizer. The flexible application of this herbal pair can significantly alleviate damp-heat symptoms in patients with MAFLD. A proven case is included for illustration.关键词：metabolic associated fatty liver disease;non-alcoholic fatty liver disease;damp-heat accumulation syndrome;Tufuling （Smilacis Glabrae Rhizoma）;Shengtoucao （Melilotus Suaveolens Ledeb）;Peilan（Eupatorii Herba）;herbal pair;traditional Chinese medicine therapy
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发布时间：2024-09-30 - 摘要：ObjectiveTo explore the hypolipidemic mechanism of alisol A based on in vitro cell experiment， network pharmacology and molecular docking technology.MethodsHepG2 cells were selected for oil red O staining and the measurement of total cholesterol （TC） and triglyceride （TG） to preliminarily assess whether alisol A could improve lipid deposition in HepG2 cells. The potential targets of alisol A and hypolipidemic activity were identified through network pharmacology. The protein-protein interaction （PPI） network and an "alisol A-potential target-hypolipidemic activity-pathway" network were constructed based on the intersection targets. Gene Ontology （GO） and Kyoto Encyclopedia of Genes and Genomes （KEGG） enrichment analyses were conducted. Finally， alisol A was docked with the identified potential targets of hypolipidemic activity.ResultsThe cell experiment results showed that alisol A inhibited lipid deposition in an OA/PA-induced high-lipid HepG2 cell model. Network pharmacology identified 11 potential targets of hypolipidemic activity of alisol A. The target proteins were primarily enriched in pathways such as the peroxisome proliferator-activated receptor （PPAR） signaling pathway. The results of molecular docking showed that alisol A and potential targets had strong binding activity.ConclusionAlisol A effectively inhibited lipid deposition in a high-lipid HepG2 cell model， suggesting its potential hypolipidemic activity. The mechanism of action may involve multiple signaling pathways， including the PPAR signaling pathway and 11 targets such as serine/threonine kinase 1 （AKT1）. These findings provide a theoretical basis for further research into the hypolipidemic activity and mechanism of alisol A.关键词：hyperlipidemia;alisol A;hypolipidemic mechanism;HepG2 cells;network pharmacology;molecular docking;traditional Chinese herbal medicine research
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发布时间：2024-09-30 - 摘要：ObjectiveBased on the classic traditional Chinese medicine （TCM） theory of "Yougu Wuyun （existing defects without causing fatality）"， the study aimed to explore the different effects of Fuzi （Aconiti Lateralis Radix Praeparata） decoction on the heart of both healthy and chronic heart failure mice.MethodsEight-week-old male SPF C57BL/6J mice were randomly divided into control group （Ctrl）， Fuzi group （FZH）， doxorubicin group （Dox）， and doxorubicin plus Fuzi group （Dox+FZH）. Mice in Dox and Dox+FZH groups received intraperitoneal injections of 5 mg/kg doxorubicin every 3 days. Mice in Ctrl and FZH groups received equivalent volumes of saline （9 g/L） intraperitoneally. On the first day of the experiment， mice in Dox and Dox+FZH groups received intraperitoneal injections of 5 mg/kg doxorubicin， followed by daily gavage with 2 g/kg Fuzi Decoction for mice in FZH and Dox+FZH groups. Mice in Ctrl and Dox groups were gavaged with an equivalent volume of normal saline solution （9 g/L）. The modeling period lasted for 4 weeks. The general condition of the mice was observed， and survival rate， heart weight， body weight， heart weight ratio， heart-to-tibia length ratio， and echocardiographic parameters were statistically analyzed. The levels of brain natriuretic peptide （BNP） and cardiac troponin I （cTnI） in cardiac tissue and serum of mice were measured. Apoptosis-related protein expression in heart tissue was detected， and the cross-sectional area of individual cardiomyocytes was observed to assess the effects of Fuzi on myocardial injury in healthy and chronic heart failure mice.Results①In a healthy state， mice in Ctrl and FZH groups had shiny fur， proportional body shape， and normal limb movement， with no deaths observed in either group. Compared with mice in Ctrl group， mice in FZH group showed a decrease in heart weight， heart weight ratio， heart-to-tibia length ratio， left ventricular ejection fraction， left ventricular fractional shortening， heart rate， and systolic left ventricular posterior wall thickness （P<0.05）， along with an increase in left ventricular end-diastolic diameter （P<0.05）. Mice in FZH group showed higher Cleaved-caspase3 protein expression （P<0.05）， and lower Bcl2/Bax ratio （P<0.05） than mice in Ctrl group. There was no significant difference in serum BNP and cTnI levels （P>0.05）. The cross-sectional area of individual cardiomyocytes in heart tissue slices was significantly reduced in FZH group mice （P<0.05）. ANP gene expression in FZH group mice was higher than that in Ctrl group mice （P<0.05）. ②In a chronic heart failure state， mice in Dox group had dull fur， were emaciated， showed slow activity， and had reduced food intake， while mice in Dox+FZH group showed improved activity and food intake compared with mice in Dox group. There were 6 deaths in Dox group and 3 deaths in Dox+FZH group. Fuzi improved the survival rate of mice in pathological states， but the difference was not statistically significant （P>0.05）. Compared with mice in Dox group， mice in Dox+FZH group had a decrease in heart rates （P<0.05） and a slight increase in left ventricular ejection fraction， but not statistically significant （P>0.05）. The Bcl2/Bax ratio was significantly higher （P<0.05） and Cleaved-Caspase3 protein expression was lower in Dox+FZH group mice than in Dox group mice， but not statistically significant （P>0.05）. Serum BNP and cTnI levels were reduced （P<0.05）， and the cross-sectional area of individual cardiomyocytes in heart tissue slices was enlarged in Dox+FZH group mice （P<0.05）. There was no significant difference in ANP gene expression between Dox group mice and Dox+FZH group mice （P>0.05）.ConclusionFuzi has toxic effects on the heart of healthy mice， but has certain therapeutic effects on mice with chronic heart failure.关键词：Fuzi （Aconiti Lateralis Radix Praeparata）;chronic cardiac failure;traditional Chinese medicine theory;traditional Chinese herbal medicine;toxicity and efficiency study;medication safety
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发布时间：2024-09-30 - 摘要：ObjectiveTo explore the active ingredients of Ganmai Dazao Decoction （GDD） combined with Baihe Zhimu Decoction （BZD） and the potential targets for the treatment of depression by network pharmacology， and verify the interaction between the main active ingredients and the key targets by molecular docking， surface plasmon resonance （SPR）， and thermal shift assay experiments.MethodsTCMSP， HIT， BATMAN-TCM and ECTM databases were used to screen the effective compounds in GDD combined with BZD. TCMSP， CTD and PHARMAPPER databases were used to obtain the potential targets of GDD combined with BZD. GeneCards and GEO databases were used to obtain depression-related targets， and the potential therapeutic targets for depression were obtained after intersection with above targets. The target protein-protein interaction （PPI） network was constructed using String database. Gene Ontology （GO） and Kyoto Encyclopedia of Genes and Genomes （KEGG） enrichment analysis were performed using DAVID and KEGG databases. Cytoscape software was used to construct the corresponding network to obtain the main active ingredients and key targets. Discovery studio software was used for molecular docking. SPR technology was used to detect the binding activity of active ingredients and target. Thermal migration assay was used to detect the binding effect of main active ingredients and target.ResultsAfter ADMET screening， 160 active components of GDD combined with BZD were obtained， and 763 potential anti-depression targets were obtained after intersection of depression-related targets and differentially expressed genes of depressed patients. PPI network analysis， GO and KEGG enrichment analysis showed that 10 signaling pathways such as mitogen-activated protein kinase（MAPK） signaling pathway may play an important role， of which MAPK14 was the most important. Molecular docking and SPR experiments showed that formononetin， licochalcone A and vestitol were the main active ingredients of GDD combined with BZD， which could bind to MAPK14 protein with the affinity of 2.36 μmol/L， 26.01 μmol/L， 11.30 μmol/L， respectively. The thermal migration assay showed that these 3 molecules could significantly improve the thermal stability of MAPK14 after binding to MAPK14， indicating that these 3 molecules could interacted with MAPK14.ConclusionsMAPK14 is a potential target for the treatment of depression， GDD combined with BZD bind to MAPK14 through 3 active ingredients. The molecular mechanism of GDD combined with BZD in treating depression was explained from the point of view of direct action of active molecules for the first time.关键词：depression;Ganmai Dazao Decoction;Baihe Zhimu Decoction;surface plasmon resonance technology;network pharmacology;mechanism of action
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发布时间：2024-09-30 - 摘要：Diabetic nephropathy （DN） is one of the most common complications of diabetes. Traditional Chinese Medicine （TCM） identifies internal accumulation of damp-heat as the key pathogenesis in DN， recommending "clearing damp-heat" as the primary treatment method. The herb pair of Huangqin （Scutellariae Radix） and Huanglian （Coptidis Rhizoma） is a representative pair for clearing damp-heat. Modern studies have shown that this herb pair and its main active components have therapeutic effects on DN. This article reviews recent literature on the Huangqin （Scutellariae Radix） and Huanglian （Coptidis Rhizoma） herb pair and its primary active components， summarizing the effects from various perspectives including regulating glucose and lipid metabolism disorders， reducing renal cell apoptosis， alleviating renal inflammation and fibrosis， modulating gut microbiota， and regulating gene transcription. This article provides a systematic theoretical basis for the clinical application and development of the Huangqin （Scutellariae Radix） and Huanglian （Coptidis Rhizoma） herb pair.关键词：diabetic nephropathy;Huangqin （Scutellariae Radix）;Huanglian （Coptidis Rhizoma）;herb pair;berberine;baicalin;traditional Chinese herbal medicine research;mechanism of action
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发布时间：2024-09-30 - 摘要：Mechanism and research progress of Atractylodis Rhizoma tonifying spleen and resolving dampness is reviewed. Ancient physicians often used Atractylodis Rhizoma to treat various diseases related to spleen and stomach dampness. The components of Atractylodis Rhizoma can improve gastric emptying and small intestine propulsion rate， also can increase gastrin and motilin， and promote gastric acid secretion and enhance gastrointestinal motility. Moreover，it can decrease vasoative intestinal peptide levels and inhibit excessive intestinal peristalsis. Atractylodis Rhizoma can regulate gastrointestinal dysfunction in a bidirectional manner. It can improve abnormal morphology of gastric mucosa. It also can reduce gastric tissue injury and improve abnormal structure of intestinal tissue. The main effective component of Atractylodis Rhizoma in resolving dampness is volatile oil， which can lead to fluid loss， increased blood viscosity， affect salivary gland secretion， cause dry mouth， and decrease the expression of aquaporin 2 in the kidney. Atractylodis Rhizoma and its extracts can reduce the content of aquaporin in the stomach， colon， and urine of rats， regulating fluid metabolism in multiple organs. Therefore， Atractylodis Rhizoma achieves the effects of tonifying spleen and resolving dampness from various aspects such as organ morphology， gastrointestinal hormone level， and aquaporin expression.关键词：Atractylodis Rhizoma;tonifying spleen;resolving dampness;spleen deficiency dampness obstruction syndrome;mechanism of action;traditional Chinese herbal medicine research
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发布时间：2024-09-30
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