最新刊期
期 8 ， 2023
- 摘要：Liver cirrhosis belongs to the category of “liver accumulation” in traditional Chinese medicine （TCM）， which has a high mortality rate with its progression. Disease-syndrome combined differentiation is the main TCM clinical treatment strategy in China today. The rapid development of antiviral drugs and minimally invasive technology， as well as the wide application of novel traditional Chinese patent medicines and TCM simple preparations against liver fibrosis， have demonstrated distinctive medical advantages in reducing the morbidity and mortality of cirrhosis in China. This paper mainly expounds several clinical issues in the application of disease-syndrome combined differentiation strategy in the diagnosis and treatment of liver cirrhosis and its complications， including： anti-liver fibrosis/cirrhosis by the method of strengthening vital qi and removing stasis； treatment of upper gastrointestinal bleeding due to cirrhosis by gastroscopy combined with the method of invigorating deficiency， removing stasis and clearing heat； TCM syndrome differentiation， diagnosis and treatment of refractory ascites due to liver cirrhosis； and the method of nourishing the kidney and liver to promote hepatocyte recovery and compensation. The evidence of clinical efficacy has revealed the evolution of the core pathogenesis of liver cirrhosis， namely “qi deficiency and blood stasis” and “yin deficiency and stasis-heat”， but more clinical research data are needed to support the finding. It requires more standardized evidence-based support to advance the establishment of clinical protocols for the disease-syndrome combined differentiation and treatment of cirrhosis and its complications.关键词：cirrhosis;disease-syndrome combined differentiation;qi deficiency and blood stasis;yin deficiency and stasis-heat;clinical research
- 29
- |
- 0
- |
- 0
发布时间：2023-08-05 - 摘要：As the common pathological basis of various chronic liver diseases， liver fibrosis could further progress to cirrhosis， causing liver dysfunction and portal hypertension. Anti-liver fibrosis has always been an important treatment strategy for chronic liver diseases and a research focus in hepatology. Traditional Chinese medicine （TCM） monotherapy or combination therapy with Western medicine can significantly alleviate liver fibrosis， prevent the decompensation of liver cirrhosis， improve long-term efficacy， reduce the incidence of liver cancer， and improve the prognosis. TCM has been playing an important role in the treatment of liver fibrosis by virtue of its precise clinical efficacy， overall regulation and low adverse effects.关键词：liver fibrosis;liver cirrhosis;traditional Chinese herbal medicine;clinical treatment;evidence-based medicine;review and commentary
- 39
- |
- 0
- |
- 0
发布时间：2023-08-05 - 摘要：This paper reviews the advances in the diagnosis and treatment of cirrhotic portal hypertension （CPHT） with integrated traditional Chinese and Western medicine （ITCWM）. CPHT is a series of clinical syndromes in decompensated cirrhosis characterized by elevated pressure in the portal venous system， with secondary disorders such as esophagogastric varices， refractory ascites， and hepatic encephalopathy. Currently， CPHT is mainly diagnosed and graded based on the hepatic venous pressure gradient measurement， but it is difficult to be carried out routinely in clinical practice. Therefore， various non-invasive diagnostic methods have become a hot research topic. The aim of CPHT treatment is to reduce portal vein pressure， prevent and treat various serious complications. The treatment options include etiological treatment， symptomatic treatment， antihepatic fibrosis， reducing portal venous blood flow， and lowering intrahepatic resistance， etc.， involving a variety of treatment methods such as drugs， endoscopy， intervention and surgery. The combined differentiation of disease and syndrome is the main pattern for the TCM treatment of CPHT， and the ITCWM has certain advantages in terms of efficacy. In the future， in order to better guide clinical practice， it is necessary to further clarify the competitive aspects and mechanism of action of the ITCWM， and to form standardized ITCWM treatment guidelines.关键词：liver cirrhosis;portal hypertension;integrated traditional Chinese and western medicine;clinical diagnosis and treatment;disease-syndrome combined differentiation
- 11
- |
- 0
- |
- 0
发布时间：2023-08-05 - 摘要：Cirrhotic ascites belongs to the category of “tympanites” in traditional Chinese medicine （TCM）. It is divided into uncomplicated type and refractory type in modern medicine， and the latter has a very poor prognosis. The TCM pathogenesis of cirrhotic ascites is intermingled deficiency and excess， and its deficiency syndrome mainly relates to spleen-kidney yang deficiency or liver-kidney yin deficiency. In this article， we reviewed the improvements in TCM and Western medicine understanding of intractable cirrhotic ascites， introduced the recent progress of diagnosis and treatment in modern medicine， and focused on the TCM syndrome differentiation and treatment and the diagnostic and treatment strategy of integrated medicine in order to improve the understanding and management of cirrhotic ascites.关键词：liver cirrhosis;refractory ascites;integrated traditional Chinese and western medicine;diagnosis;treatment;review and commentary
- 16
- |
- 0
- |
- 0
发布时间：2023-08-05 - 摘要：Primary hepatic carcinoma （PHC） has a high incidence and mortality in China. Cirrhosis and hepatic carcinoma are closely related. The degree of cirrhosis determines different treatment methods and prognosis， and the treatment of cirrhosis complicated with hepatic carcinoma is more difficult. There is still a lack of high-quality clinical studies on cirrhosis complicated with hepatic carcinoma， and most are case studies. Studies have shown that traditional Chinese medicine can improve the liver microenvironment and reduce the risk of recurrence and metastasis of hepatic carcinoma. It is suggested that clinical practice should focus on the joint treatment of hepatic carcinoma and cirrhosis to create optimal treatment options for patients. The use of integrated traditional Chinese and Western medicine can improve liver function and prevent various types of decompensation events.关键词：cirrhosis;hepatic carcinoma;integrated traditional Chinese and Western medicine therapy;strengthening vital qi to eliminate pathogenic factor
- 16
- |
- 0
- |
- 0
发布时间：2023-08-05 - 摘要：This article states that blood stasis is the pathogenesis of liver cirrhosis， and explains the theoretical basis and practical application of the blood-activating and stasis-resolving method in the treatment of liver cirrhosis from the perspective of integrated traditional Chinese and Western medicine. Focusing on the traditional Chinese medicine （TCM） pathogenesis as well as syndromes and treatment of liver cirrhosis， we first compare the similarities and differences in the concepts of liver between the two medical systems， and hold that the liver microcirculatory system is termed as “Gan Luo” （liver collaterals） in TCM， which help to maintain the physiological homeostasis of the liver； and that the microcirculatory disorder （or stasis and obstruction in “liver collaterals”） is the core pathology（pathogenesis） of liver cirrhosis. As has been proved in TCM classical literature， experience of famous TCM doctors in modern times and contemporary evidence-based medical evaluation， blood-activating and stasis-removing method is an important TCM treatment method for liver cirrhosis. However， it should be applied flexibly according to the different effects of herbs for activating blood and resolving stasis and different stages of the disease， and attention should also be paid to appropriate coordination with other treatment methods in the real practice. Finally， we propose that improving liver microcirculation is a pivot pharmacological basis and therapeutic strategy for the treatment of liver cirrhosis with blood-activating and stasis-resolving herbs to eliminate stasis and generate new blood.关键词：liver cirrhosis;activating blood and resolving stasis method;liver collateral;hepatic microcirculation;traditional Chinese herbal medicine;integrated traditional Chinese and western medicine
- 5
- |
- 0
- |
- 0
发布时间：2023-08-05 - 摘要：This article reviews the research progress on the active ingredients and mechanisms of hepatoprotective effects of oysters. The active ingredients of hepatoprotective effect of oyster soft tissue mainly include polysaccharide， taurine， protein （active peptide） and microelement， etc. The mechanisms of action are related to anti-inflammation， antioxidation， improvement of lipid metabolism， and regulation of gut microbiota， etc.关键词：oyster;liver diseases;alcoholic liver disease;autoimmune liver disease;active ingredient;mechanism of action;research progress
- 9
- |
- 0
- |
- 0
发布时间：2023-08-05 - 摘要：ObjectiveTo investigate the effect of hyperoside on lipid metabolism in a high-fat diet-induced non-alcoholic fatty liver disease （NAFLD） model rats and its mechanism of action.MethodsWistar rats were fed a high-fat diet for 6 weeks. After successful modeling， they were randomly divided into a high-fat diet （HFD） group （n=10）， a hyperoside low-dose group ［50 mg·kg-1 （LDG）， n=10］ and a hyperoside high-dose group ［100 mg·kg-1 （HDG）， n=10］. A negative control （NC） group was set with rats being fed with normal chow （n=10）. All groups were administered by gavage once a day. The weight of rats in each group was measured weekly. After 6 weeks of intervention， the liver function and lipid metabolism indexes of the rats were detected， the pathomorphological changes of rat liver tissues were observed with the hematoxylin-eosin （HE） staining， and the expression levels of lipid metabolism-related proteins in rat liver tissues were detected with Western blot method.ResultsThere was significant steatosis in the liver of rats in the HFD group compared with the condition in the NC group. Compared with the condition in the HFD group， there was significant improvement in lipid droplet vacuoles and hepatic steatosis in rats with high doses of hyperoside； the levels of total cholesterol （TC）， triacylglycerol （TG）， and low-density lipoprotein （LDL） in liver tissues decreased significantly （P<0.05）； the expression levels of lipid synthesis-related proteins including cholesterol regulatory element binding protein 1 （SREBP1）， acetyl coenzyme A carboxylase （ACC）， fatty acid synthase （FASN）， and stearoyl coenzyme A desaturase 1 （SCD1） were downregulated significantly （P<0.05）； the expression levels of lipolysis-related proteins including peroxisome proliferator-activated receptor α （PPARα）， carnitine palmitoyltransferase 1A （CPT1A） increased significantly （P<0.05）； and the expression level of phosphorylated adenylate-activated protein kinase α （p-AMPKα） also observably increased （P<0.05）. All the differences were statistically significant.ConclusionHyperoside may inhibit hepatic lipid synthesis and promote lipolysis by regulating the AMPK pathway， indicating that it could be a potential drug for the treatment of NAFLD.关键词：non-alcoholic fatty liver disease （NAFLD）;hyperoside;AMPK signaling pathway;lipid metabolism;rat model;traditional Chinese herbal medicine research
- 9
- |
- 0
- |
- 0
发布时间：2023-08-05 - 摘要：ObjectiveTo investigate the clinical characteristics and traditional Chinese medicine （TCM） constitution distribution pattern of lean metabolic associated fatty liver disease （MAFLD） in the elderly in Shanghai communities， and to provide an objective basis for the prevention and treatment of lean MAFLD.MethodsAccording to the prevalence of MAFLD， elderly people who participated in community-based physical examinations in Jiading District， Shanghai were selected and divided into lean MAFLD group，lean no-MAFLD group and non-lean MAFLD group to investigate their general information including gender， age， BMI， smoking and alcohol consumption， as well as fasting blood glucose （FBG）， triglyceride （TG）， total cholesterol （TC）， low-density lipoprotein cholesterol （LDL-C）， high-density lipoprotein cholesterol （HDL-C）， alanine aminotransferase （ALT）， aspartate aminotransferase （AST）， total bilirubin （TBil）， Serum creatinine （Scr）， uric acid （UA）， white blood cells （WBC）， neutrophil percentage （NEU%）， lymphocyte percentage （LYMPH%）， hemoglobin （Hb） and platelet count （PLT）， and other laboratory indices. The distribution pattern of TCM body constitution types was explored and the risk factors of lean MAFLD were analyzed with the logistic regression model.Results①A total of 48，448 study subjects were finally included， including 2，270 patients with lean MAFLD， with a prevalence of 4.7% in the community-based elderly population and a male-to-female ratio of 1：3.27. ②The male-to-female ratio and the proportion of smoking and alcohol consumption in the lean MAFLD group were lower than those in the lean no-MAFLD group （P<0.05）. The lean MAFLD group had lower levels of HDL-C， Scr， and NEU% （P<0.05） and higher levels of BMI， TG， TC， LDL-C， FBG， ALT， UA， WBC， LYMPH%， Hb and PLT （P<0.05） than the lean no-MAFLD group. The male-to-female ratio and the proportion of smoking and alcohol consumption were lower in the lean MAFLD group than those in the non-lean MAFLD group （P<0.05）. The lean MAFLD group had lower levels of TG， FBG， ALT， AST， Scr， WBC， and Hb （P<0.05） and higher levels of TC， LDL-C， HDL-C， UA， LYMPH% and PLT （P<0.05） than the non-lean MAFLD group. ③The lean MAFLD group had a higher proportion in TCM constitutions including yin deficiency （20.8%）， qi deficiency （18.2%）， phlegm-damp （9.3%）， damp-heat （8.2%） and blood stasis （3.0%） （P<0.05） than the lean no-MAFLD group. The lean MAFLD group had a higher proportion in TCM constitutions including qi deficiency （18.2%）， damp-heat （8.2%） and yang deficiency （5.3%） （P<0.05） than the non-lean MAFLD group. ④ Elevated levels of BMI， TG， LDL-C and FBG may be risk factors for the development of lean MAFLD in the elderly ［OR （95% CI） 1.500 （1.432-1.572）， 2.125 （1.896-2.382）， 2.089 （1.682-2.595） and 1.163 （1.133-1.192）， respectively］. The TCM constitution types of blood stasis， damp-heat， phlegm-damp， and yin deficiency may be risk factors for the development of lean MAFLD in the elderly ［OR （95% CI） 1.716 （1.256-2.346）， 1.702 （1.387-2.089）， 1.543 （1.272-1.873）， and 1.146 （1.003-1.310）， respectively］.ConclusionPrevention and treatment of lean MAFLD in the elderly over 60 years of age should focus on reducing BMI as well as lipid and uric acid levels， and controlling blood glucose. The identification of features of each TCM constitution type is recommended. Regular physical examinations and individualized treatment for the elderly with constitution types of phlegm-damp， damp-heat， blood-stasis and qi-deficiency and yin-deficiency （which are two main types in the elder） can help prevent and improve the symptoms of lean MAFLD.关键词：metabolic associated fatty liver disease;non-alcoholic fatty liver disease;the elderly;traditional Chinese medicine constitution;clinical characteristics
- 9
- |
- 0
- |
- 0
发布时间：2023-08-05 - 摘要：ObjectiveTo investigate the inhibitory effect of cinobufagin （CBF） on the proliferation of hepatocellular carcinoma （HCC） cells， reveal the related genes and signaling pathways by transcriptomic sequencing， and explore the possible mechanism of action of anti-HCC effect of CBF.MethodsSMMC-7721 and JHH7 cells were treated with CBF at different concentrations （0， 2， 4， 8， 16 and 32 μmol·L-1） at 24， 48 and 72 h. WST-1 assay was used to assess the proliferation rate of HCC cells. Based on the results of WST-1 assay， SMMC-7721 and JHH7 cells were intervened with CBF 2 μmol·L-1 for 24 h， differentially expressed genes were analyzed with transcriptomic gene expression sequencing， and bioinformatics analysis was performed. Based on literature reports and the TCGA database， the expression of a few differently expressed mRNAs in HCC tissues was discovered. The reverse transcription quantitative real-time polymerase chain reaction （RT-qPCR） was used to detect and validate the expression of CBF target genes.Results①CBF had a proliferation-inhibitory effect on SMMC-7721 and JHH7 cells in a concentration-time dependent manner. ②Transcriptomic sequencing results showed that in CBF-treated SMMC-7721 cells， a total of 578 differentially expressed genes （309 up-regulated genes and 269 down-regulated genes） were obtained； in CBF- treated JHH7 cells， a total of 611 differentially expressed genes （349 up-regulated genes and 262 down-regulated genes） were obtained； and a total of 106 intersecting genes were obtained in the two groups of cells （fold change>2， P<0.05）. ③Bioinformatics analysis showed that the transcript levels of ATF3， CBR1， CKAP4， GADD45B， KCNK5 and ORC5 were aberrantly expressed in HCC tissues and correlated with patient prognosis. ④The RT-qPCR results showed that CBF promoted the expression of ATF3， KCNK5 and GADD45B genes and inhibited the expression of CBR1， CKAP4 and ORC5 genes in SMMC-7721 and JHH7 cells， which was consistent with the sequencing results.ConclusionCBF can inhibit the proliferation of HCC cells， and the mechanism may be related to the regulation of ATF3， KCNK5， GADD45B， CBR1， CKAP4 and ORC5 expression.关键词：cinobufagin;hepatocellular carcinoma cells;transcriptomics;mechanism of action;research of traditional Chinese herbal medicine
- 5
- |
- 0
- |
- 0
发布时间：2023-08-05 - 摘要：The gut microbiota is an important factor in the development of hypertension. According to traditional Chinese medicine theory， the heart and small intestine are interconnected in meridians， cooperate with each other physiologically， and influence each other pathologically， i.e.， “the heart and small intestine are exteriorly and interiorly interrelated”. Based on the theory of “the heart and small intestine forming an exterior and interior relationship” and review of relevant literature， the correlation between gut microbiota and hypertension， and the preventive and therapeutic effects of traditional Chinese herbal medicines on hypertension through regulating gut microbiota were discussed， with a view to providing ideas for the clinical treatment of hypertension.关键词：hypertension;gut microbiota;the heart and small intestine forming an exterior and interior relationship;traditional Chinese herbal medicine;traditional Chinese medicine therapy
- 16
- |
- 0
- |
- 0
发布时间：2023-08-05 - 摘要：Clinical treatment mode of miscellaneous diseases initially left traces in fever， and then gradually formed a special field， and set up medicine rules of zang-fu organs， and finally established the disease-syndrome and treatment-medicine system. Nowadays， while paying attention to the inheritance of principle-method-recipe-medicines and the exchange of clinical experience， traditional Chinese medicine also attaches importance to exploring the rule of differentiation and treatment and special prescriptions in modern diseases.关键词：miscellaneous diseases;traditional Chinese medicine classics;syndrome;clinical treatment;ancient pattern;modern change
- 22
- |
- 0
- |
- 0
发布时间：2023-08-05 - 摘要：ObjectiveTo investigate the molecular mechanism of Yishen Juanbi Wan in the treatment of rheumatoid arthritis （RA） based on a network pharmacology approach.MethodsActive components of Yishen Juanbi Wan were obtained from the TCMSP、TCMIP、HERB and ETCM databases， and their targets of active components were predicted using the SwissTarget Prediction database. RA-related genes were retrieved from databases including GeneCards， DisGeNET、OMIM and TTD databases. The targets of Yishen Juanbi Wan and the targets related to RA were mapped to obtain the intersection targets， PPI networks were constructed with the help of STRING database， the key targets of Yishen Juanbi Wan in treating RA were screened using Cytoscape 3.7.2 software， and GO and KEGG enrichment analyses were performed with Cytoscape 3.9 software.ResultsA total of 185 active components were obtained for the treatment of RA， including those key components like kaempferol， luteolin， quercetin and palmatine， and the core gene targets were TNF， IL⁃6， IL⁃1β， VEGFA， and STAT3， etc. KEGG analysis showed that the main signaling pathways involved were TNF， MAPK， IL-17， VEGF， NF-κB， and rheumatoid arthritis.ConclusionWith the advantages of multi-component， multi-target and multi-pathway synergistic effects in the treatment of RA， Yishen Juanbi Wan can effectively regulate the body's immune function， affect apoptosis and inhibit inflammatory response by regulating relevant signaling pathways.关键词：rheumatoid arthritis;Yishen Juanbi Wan;traditional Chinese medicine therapy;network pharmacology;mechanism of action
- 12
- |
- 0
- |
- 0
发布时间：2023-08-05 - 摘要：The clinical application of fire acupuncture to improve the post-stroke spasticity was discussed based on Professor Shao Jingming's idea of treating Shen. We proposed the idea of regulating Shen of the channels and meridians as well as qi and blood， which was developed from Professor Shao's idea of regulating Shen of physician's body and mind and regulating Shen of patient's emotion and mind. The musculotendinous junctions， Dazhui （GV 14）， Fengchi （GB 20）， Baihui （GV 20）， Xinshu （BL 15）， Taichong （LV 3） and other points were selected for the treatment of post-stroke spasticity with fire acupuncture， and the clinical results were quite satisfactory. Two proven cases were provided.关键词：cerebral apoplexy;stroke;meridian⁃tendon disease;spastic hemiplegia;acupuncture;fire acupuncture;clinical experience
- 6
- |
- 0
- |
- 0
发布时间：2023-08-05 - 摘要：A new explanation was given to the controversial issues of Dahuang Gansui Decoction article in Synopsis of Golden Chamber. Through the method of collation and exegesis，the research result showed that the original appearance of “like dun style” was “like dun-dun style”. It was more accurate to extend “like dun-dun style” to the feeling of heavy and falling. The pronunciation of “Dui” should be the first tone instead of the fourth. The term “multipara” was not a new postpartum woman， but originally referred to a woman with childbearing history. Its modern connotation should be expanded to the women in the sexually active period. The blood formed by “the combination of water and blood” was the menstrual blood stasis rather than the postpartum lochia. This article might imply that the patient's menstruation was abnormal. Based on symptoms such as the feeling of lower abdomen falling down， slight difficulty in urination and the characteristics of susceptible persons， this article could be understood from pelvic inflammatory disease， urinary tract infection and other common female diseases.关键词：Synopsis of Golden Chamber;Gynecological diseases;Dahuang Gansui Decoction;Chinese classic formulas;interpretation
- 9
- |
- 0
- |
- 0
发布时间：2023-08-05 - 摘要：ObjectiveTo study the protective effects of Erlong Zuoci Wan （ELZC） on cochlear spiral ganglion neurons （SGNs） in mice with presbycusis and explore its mechanisms.Methods①Twenty-seven C57BL/6J mice were randomly divided into three groups： control group， ARHL group and ELZC group， with nine mice in each group. The 2-month-old C57BL/6J mice were taken as control， and the 3-month-old C57BL/6J mice were randomly divided into two groups that were fed diets containing Erlong Zuoci Wan （ELZC group） or standard diets （presbycusis group） for 6 months. Auditory brainstem response （ABR） was employed to test changes in hearing threshold. HE staining was used to evaluate the morphologic changes in mouse cochlear spiral ganglion neurons. The expression levels of LC3， p62 and SIRT1 in SGNs were detected by immunofluorescence. TUNEL assay was used to detect the apoptosis of SGNs. ②In the ex vivo study， cochlear basement membrane in C57BL/6J mice was used as an ex vivo culture model， which were divided into 5 groups： blank control group， H2O2 model group （0.3 mmol L-1） and ELZC groups with low， middle and high concentrations of ELZC （5 μg·mL-1， 10 μg·mL-1， 50 μg·mL-1）. The morphological changes in SGNs were assessed by NF200 immunohistochemistry. Western blot was employed to analyze the protein expressions of SIRT1， LC3-Ⅱ， p62， cleaved Caspase-3， and Caspase-3.Results①The mice （9 months old） in presbycusis group had significantly higher hearing threshold （P<0.05）， significantly fewer SGNs in cochlea （P<0.05）， significantly lower expression of SIRT1 protein （P<0.05）， higher expressions of autophagy related proteins LC3-Ⅱ and p62 （P<0.05）， and more TUNEL positive cells （P<0.05） than mice in control group. ELZC could significantly lower hearing threshold （P<0.05） and significantly improve SGNs survival （P<0.05） in mice with age-related hearing loss. The mice in ELZC group showed significantly higher SIRT1 protein expression （P<0.05）， lower LC3-Ⅱ and p62 expressions （P<0.05）， and significantly fewer TUNEL-positive cells （P<0.05） than those in presbycusis group. ②In the ex vivo study， exposure to H2O2 led to significant damage， shrinkage， and condensation of SGNs. After H2O2 exposure， SIRT1 protein expression was significantly lower （P<0.05）， and the protein expression levels of LC3-Ⅱ and p62 and the ratio of cleaved Caspase-3/Caspase-3 were higher than the condition in the blank control group （P<0.05）. SGNs damage and loss were alleviated， accompanied by the improvement of nerve fiber thinning and fragmentation in ELZC group compared with the condition in H2O2 model group. Besides， 10 μg·mL-1 and 50 μg·mL-1 ELZC treatment significantly increased SIRT1 expression （P<0.05）， and significantly downregulated the protein expressions of LC3-Ⅱ and p62 and the ratio of cleaved Caspase-3/Caspase-3 （P<0.05）.ConclusionELZC can reduce degeneration， improve autophagy and inhibit apoptosis of SGNs in presbycusis mice， and the mechanisms may be related to upregulation of SIRT1 protein expression.关键词：deafness;classical famous prescriptions;mechanism of action;autophagy;apoptosis;model mouse;traditional Chinese herbal medicine research
- 29
- |
- 0
- |
- 0
发布时间：2023-08-05 - 摘要：The research progress on the mechanism of traditional Chinese medicine（TCM） in regulating nuclear transcription factor-κB （NF-κB） signaling pathway to prevent endometriosis （EMT） is reviewed. In recent years， the use of TCM monomer and compound to regulate the NF-κB signaling pathway in the treatment of EMT has become a research focus. TCM plays an anti-inflammatory role by inhibiting the NF-κB signaling pathway that regulates the expression of target genes， including the matrix metalloproteinases（MMPs）family， interleukin（IL）family， cyclooxygenase-2 （COX-2）， vascular endothelial growth factor （VEGF）， prostaglandin E2 （PGE2）， intercellular adhesion molecule-1 （ICAM-1）， vascular cell adhesion molecule-1 （VCAM-1）， etc. These together act as anti-inflammatory and inhibit cell proliferation， adhesion， and invasion， then block the cell cycle， promote apoptosis， inhibit angiogenesis.关键词：endometriosis;NF-κB signaling pathway;traditional Chinese medicine;mechanism of action;research progress
- 25
- |
- 0
- |
- 0
发布时间：2023-08-05 - 摘要：Based on the pathological mechanism of intracerebral hemorrhage （ICH）， we reviewed the recent studies on the bidirectional interaction between neuroinflammation and gut microbiota after ICH， with the brain-gut axis as the core. The gut microbiota and its metabolites are important factors in the regulation of neuroinflammation after ICH， which may act through activation of immune cells， modulation of cytokines， intervention in the brain-gut axis （pro-inflammatory or anti-inflammatory）， or may directly affect intestinal function and inflammatory responses by acting on the intestinal environment. The brain-gut axis is a key pathway for these regulatory effects. Microbiota transplantation and traditional Chinese medicine therapy are promising treatment methods for ICH.关键词：intracerebral hemorrhage;stroke;neuroinflammation;gut microbiota;brain-gut axis;traditional Chinese medicine therapy;research progress
- 21
- |
- 0
- |
- 0
发布时间：2023-08-05
- Technical support is provided by Beijing Founder electronics co., LTD 沪ICP备13044091号
沪公网安备 31011502015228号 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
- Total Visits：70575 Visits Today：56
0