最新刊期
期 9 ， 2022
- 摘要：ObjectiveTo observe the clinical effect of Ganjiang Xiaochaihu Decoction on patients with mild infection of COVID-19 Omicron variant.MethodsOne hundred and forty-five patients with mild infection of COVID-19 Omicron variant were randomly divided into a treatment group （n=97） and a control group （n=48）. The control group was given basic routine treatment， while the treatment group was administered with Ganjiang Xiaochaihu Decoction and the basic routine treatment. After 5 days of treatment， the clinical effect was observed， and TCM syndrome scores， self-rating depression scale （SDS） scores， self-rating anxiety scale （SAS） scores and nucleic acid conversion time （NCT） were compared between the two groups.Results①During the trial， 1 case in the control group dropped out， and finally 97 cases in the treatment group and 47 cases in the control group completed the trial. ②The total effective rate of the treatment group was 99.0%， and that of the control group was 78.7%. The treatment group showed a better clinical effect compared with the control group （P<0.05）. ③After 5 days of treatment， the TCM syndrome sub-item scores and total scores in both groups decreased， and the differences were statistically significant （P<0.05）； After 5 days of treatment， the sub-item scores of pharyngeal discomfort， nasal obstruction and runny nose， loss of appetite， irritability， palpitation and the TCM syndrome total scores in the treatment group were lower than those in the control group， and the differences were statistically significant （P<0.05）. ④The scores of SDS and SAS in the two groups decreased after 5 days of treatment compared with those before treatment， and the differences were statistically significant （P<0.05）； After 5 days of treatment， the scores of SDS and SAS in the treatment group were lower than those in the control group， and the differences were statistically significant （P<0.05）. ⑤There was no statistically significant difference between the two groups in terms of nucleic acid conversion time （P>0.05）.ConclusionGanjiang Xiaochaihu Decoction has achieved a satisfactory result in treating patients with mild infection of COVID-19 Omicron variant because it can effectively improve the patients’ TCM syndromes， relieve depression and anxiety， and has the effect of “simultaneous treatment of infection and depression”.关键词：COVID-19;SARS-CoV-2;Omicron variant;Xiaochaihu Decoction;classical representative famous prescription;anxiety;depression;clinical trial
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发布时间：2022-09-30 - 关键词：COVID-19;SARS-CoV-2;Omicron variant;dog-days acupoint application;acupoint application;children;expert consensus
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发布时间：2022-09-30 - 关键词：respiratory diseases;treating winter diseases in summer;acupoint application;Shanghai style traditional Chinese medicine pediatrics;children;expert consensus
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发布时间：2022-09-30 - 摘要：Based on the theory of “treating upper portion for lower disorder， rising first for subsequent descending”， Professor Wang Xixing considers that deficiency of middle qi and lucid yang failing to rise are the key pathogenesis of prostate cancer with deficiency syndrome. Buzhong Yiqi Decoction can be used for replenishing middle jiao and strengthening vital qi to tonify qi， products with efficacy of ascending lucidity could be applied for elevating spleen qi and improving qi movement of the whole body， so as to promote qi transformation of san jiao and urination. And one proven case is presented.关键词：prostate cancer;Buzhong Yiqi Decoction;famous doctor’s experience;traditional Chinese medicine therapy
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发布时间：2022-09-30 - 摘要：Understanding febrile diseases was closely related to clinical practice. This paper explained febrile diseases from illness， text， miscellaneous diseases， quasi-diseases， and discussed clinical practice of traditional Chinese medicine from law of fever， rule of miscellaneous diseases， basis of syndrome differentiation and pattern of diagnosis and treatment. Understanding febrile diseases would contribute to the inheritance and innovation of modern Chinese medicine.关键词：Febrile Diseases;Treatise on Febrile Disease;Synopsis of Golden Chamber;clinical practice;treatment based on syndrome differentiation
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发布时间：2022-09-30 - 摘要：ObjectiveThe study used a network pharmacology approach and molecular docking technology to identify the pharmacological mechanisms of Compound Tripterygium Wilfordii Painkiller Granules（ CTWPGs ）treating rheumatoid arthritis （RA）.MethodsThe main active ingredients and targets of CTWPGs were obtained by using TCMSP， ETCM and BATMAN. RA-related targets were obtained from OMIM， Drug Bank， Gene Cards and TTD databases. Intersection targets were acquired after drug and disease target mapping. Then the protein-protein interaction network was constructed by String database to analyze the interactions and screened the core genes by topology. Finally， the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis of the core genes were carried out through Database for Annotation， Visualization， and Integrated Discovery. The visual network of “active ingredients-targets-signaling pathways” was constructed by Cytoscape3.6.0 software.ResultsA total of 47 ingredients and 34 core genes were obtained. GO enrichment analysis obtained 357 items （P<0.05）， including 299 Biological Processes， 21 Cellular Components and 37 Molecular Functions （P<0.05）. And results of KEGG enrichment analysis showed 107 signaling pathways （P<0.05）， including TNF signaling pathway， Toll-like receptor signaling pathway， and MAPK signaling pathway. Finally， the results suggested that the key active ingredients of CTWPGs included quercetin， luteolin， and triptolide. And core genes were PTGS2， JUN， AKT1， MAPK1， RELA， MAPK14， MAPK3 and TNF. The molecular mocking showed that luteolin and MAPK3， PTGS2， triptolide and MAPK3， TNF， kaempferol and MAPK14， GA30 and MAPK3， TNF， AKT1， PTGS2， baicalein and MAPK3 had good docking activity.ConclusionNetwork pharmacological studies showed that CTWPGs could play an intervention role in RA through multi-ingredients， multi-targets and multi-pathways， which had certain clinical application value.关键词：Compound Tripterygium Wilfordii Painkiller Granules;rheumatoid arthritis;network pharmacology;molecular docking
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发布时间：2022-09-30 - 摘要：The purpose of this paper is to sort out the academic thought and origin of the method of reinforcing yang and enriching yin in Xu’s pediatrics. It is considered that the TCM etiology and pathogenesis of ventricular premature beats in children may be the imbalance of qi and blood， yin and yang， and the external floating of yang deficiency due to the failure of yin deficiency to control yang. The disease is treated with Xiao’er Fumai Decoction by the method of reinforcing yang and enriching yin， and nourishing the heart and stopping palpitation. And one proven case is presented.关键词：children’s ventricular premature beats;Xu’s pediatrics;reinforcing yang and enriching yin;traditional Chinese medicine therapy
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发布时间：2022-09-30 - 摘要：The purpose of this paper is to summarize and analyze the meaning and clinical significance of professor Xu youjia’s core clinical diagnosis and treatment idea of “harmonizing the spleen and stomach” in pediatrics. He puts forward the academic viewpoint that “the child is the body of deficiency and cold”， explains the necessity of “harmonizing the spleen and stomach”， and holds that when using the method of treating different diseases with the same therapy the pathogenesis evolution and syndrome differentiation should be based on the “spleen and stomach”. Professor Xu youjia’s experience is summarized of treating different diseases with the same therapy by flexible application of the method of “harmonizing the spleen and stomach” in the diagnosis and treatment of common diseases， frequently-occurring diseases and difficult diseases in pediatrics. And two proven cases are presented.关键词：harmonizing the spleen and stomach;treating different diseases with same therapy;pediatrics;traditional Chinese medicine therapy
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发布时间：2022-09-30 - 摘要：The article introduces Professor Wang Yaoguang’s experience in the clinical diagnosis and treatment of chronic kidney disease combined with sleep disorders. Professor Wang considers that it is more applicable to treat this disease based on five zang viscera. Different syndromes are divided， including deficiency of liver blood， stagnation of liver qi， fluid retained in heart and lung， deficiency of both heart and spleen， deficiency of kidney yin， deficiency of kidney yang， and deficiency of kidney qi. It is proposed that the treatment based on cause of disease should be combined with syndrome differentiation and treatment， and multiple treatment methods could be applied together. One proven case is presented.关键词：chronic kidney disease;sleep disorder;insomnia;visceral syndrome differentiation;treatment based on syndrome differentiation;traditional Chinese medicine therapy
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发布时间：2022-09-30 - 摘要：By explaining the meaning of blood stasis and toxin and summarizing the relationship between blood stasis， toxin and ischemic stroke， this paper discussed the prevention， treatment and recovery of ischemic stroke from the microscopic indicators of blood stasis and toxin. The microscopic indicators of blood stasis and toxin could be used as risk factors and markers for the occurrence， aggravation， and recurrence of ischemic stroke. These microscopic indicators reflected changes in the micro-environment of regional tissue during the occurrence and development of ischemic stroke. What’s more， these microscopic indicators not only could prompt and improve the macroscopic syndrome differentiation of ischemic stroke， but also provided a reference for the choice of ischemic stroke treatment plan.关键词：ischemic stroke;blood stasis;toxin;microscopic indicators;preventive treatment of disease
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发布时间：2022-09-30 - 摘要：This paper summarized professor Wang Yiqin’s characteristics of clinical experience in syndrome differentiation and treatment of asthma. Professor Wang claimed that the mixture of deficiency and excess was the pathogenesis of asthma， and the combination of phlegm and blood stasis was the long-standing root of asthma. The treatment principle of asthma was to give priority to the symptoms and give consideration to the fundamental treatment in the attack period， while give priority to the fundamental treatment and give consideration to the symptoms in the remission period. Professor Wang frequently used ancient classic prescriptions and adapted to clinical symptoms. She advocated that qi should be treated first during the attack of asthma， phlegm and blood stasis should be treated at the same time， and spleen and stomach should be protected from beginning to end. According to the clinical characteristics of phlegm dampness in most children as well as phlegm and blood stasis in most adults during the attack period， she proposed Xiaopingchuan formula and Dapingchuan formula added and subtracted from classic prescriptions to treat them separately， made good use of insect drugs and pair of drugs， and paid attention to children’s inspection， auscultation， and mild medication.关键词：asthma;classic prescription;traditional Chinese medicine therapy;experience of famous doctor
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发布时间：2022-09-30 - 摘要：ObjectiveTo study the clinical efficacy of oral administration of traditional Chinese herbal medicines （TCHMs） combined with transcutaneous electrical acupoint stimulation （TEAS） in the treatment of spinal cord injury （SCI） based on the theory of warming kidneys and unblocking Du channel.MethodsTotally 100 SCI patients were randomly divided into a treatment group （n=50） and a control group （n=50）. The control group was given basic treatment and rehabilitation training， while the treatment group was treated with oral administration of TCHMs plus TEAS based on the theory of warming kidneys and unblocking Du channel besides the therapeutic measures of the control group. The duration of treatment for both groups was 12 weeks. The American Spinal Injury Association （ASIA） impairment scale grade， spinal cord neurological function scores， evoked potentials， and changes in nerve-related growth factors were compared between the two groups， and the incidence of complications was also observed.Results①During the trial， there were 2 drop-out cases in the treatment group and 4 drop-out cases in the control group； Finally 94 cases completed the trial， with 48 cases in the treatment group and 46 cases in the control group. ②After treatment， the percentage of grade D and E evaluated with ASIA impairment scale was higher in the treatment group than that in the control group （P<0.05）. ③After treatment， pain score， tactile score， and motor score were higher in the treatment group than those in the control group （P<0.05）. ④After treatment， the somatosensory evoked potentials （SEP） amplitude and motor evoked potentials （MEP） amplitude were higher in the treatment group than those in the control group （P<0.05）. ⑤After treatment， the serum levels of nerve growth factor （NGF）， brain-derived neurotrophic factor （BDNF） and neurotrophin-3 （NT-3） were higher in the treatment group than those in the control group （P<0.05）. ⑥The incidence of complications in the treatment group was lower than that in the control group， and the difference was statistically significant （P<0.05）.ConclusionOral administration of TCHMs combined with TEAS based on the theory of warming kidneys and unblocking Du channel is effective in the treatment of SCI， which can improve spinal nerve function and reduce the incidence of complications. The mechanism may be related to the enhancement of spinal cord conduction and the promotion of nerve cell repair and regeneration.关键词：spinal cord injury;traditional Chinese herbal medicine;acupuncture;transcutaneous electrical acupoint stimulation;nerve growth factor;complications;clinical trial
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发布时间：2022-09-30 - 摘要：ObjectiveTo observe the efficacy of Qingfei Huayu Decoction combined with pirfenidone in the treatment of progressive fibrosing interstitial lung disease （PF-ILD） associated with rheumatoid arthritis of lung in heat and blood stasis syndrome type.MethodsSeventy-three patients with rheumatoid arthritis-related PF-ILD were randomly divided into the control group （n=37） and the traditional Chinese medicine（TCM） group （n=36）. The control group was treated with conventional western medicine plus pirfenidone for rheumatoid arthritis， and the TCM group was treated with Qingfei Huayu Decoction on the basis of the control group. After treatment for 6 months， the clinical efficacy， forced vital capacity （FVC）， decreased forced vital capacity （ΔFVC）， lung HRCT semi-quantitative score， TCM score， erythrocyte sedimentation rate （ESR）， disease activity score （DAS28-ESR）， serum KL-6， TGF-β1 levels， maximum dose of pirfenidone and adverse reactions were compared between the two groups.Results① During the trial， 3 cases dropped out in the TCM group， 4 cases dropped out in the control group， 66 cases finally completed the trial， and 33 cases in each group. ② The total effective rate of the TCM group was 51.52%， and the total effective rate of the control group was 36.36%. There was significant difference in the overall efficacy between the two groups （P<0.05）.After treatment， the effective rate of TCM was 69.70% in the TCM group and 33.33% in the control group， and there was significant difference between the two groups （P<0.05）. ③ After treatment， the FVC in the control group and the TCM group was lower than that before treatment （P<0.05）.The FVC in the TCM group was higher than that in the control group （P<0.05）.The ΔFVC was lower in the TCM group than in the control group （P<0.05）. ④ There was no significant difference in lung HRCT semiquantitative score in the two groups before and after treatment （P>0.05）. The TCM score of the two groups was lower than that before treatment （P<0.05）.The TCM score of the TCM group was lower than that of the control group （P<0.05）. ⑤After treatment， the ESR、DAS28-ESR scores、KL-6 and TGF-β1 in the control group and the TCM group were lower than those before treatment （P<0.05）； The ESR、DAS28-ESR scores、KL-6 and TGF-β1 in the TCM group were lower than those in the control group （P<0.05）. ⑥There was no statistically significant difference in the maximum dose of pirfenidone used between the two groups （P>0.05）.ConclusionsQingfei Huayu Decoction combined with pirfenidone has a satisfactory therapeutic effect on rheumatoid arthritis-related PF-ILD. Compared with western medicine， Qingfei Huayu Decoction can improve the TCM syndrome of patients better and delay the decline of measured FVC， and the mechanism may be related to the down-regulation of serum TGF-β1 expression level.关键词：rheumatoid arthritis;interstitial lung disease;pulmonary fibrosis;Qingfei Huayu Decoction;therapy of traditional Chinese medicine;clinic trial
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发布时间：2022-09-30 - 摘要：ObjectiveTo explore the regulatory effect of serum containing traditional Chinese medicine compound with the function of tonifying the kidney and disinhibiting dampness on neutrophilic alkaline phosphatase 6（NALP6） signal transduction pathway in fibroblast-like synoviocytes of gouty arthritis （GA） rats.MethodsThe gouty arthritis model was established by adding sodium urate microcrystalline into the rat fibroblast synovial cell culture medium. The drug containing serum which is most suitable for the survival of rat synovial cells was added into the culture medium for cell experiment. The cells were divided into the blank group （normal synoviocytes）， the model group （synoviocytes + sodium urate） and the treatment group （synoviocytes + sodium urate + drug-containing serum） and each group carried on the corresponding intervention. The expression of NALP6 mRNA in synovial cells was detected by RT-PCR， the expression of NALP6， NF-κB， IκB by Western blot， the Caspase-1 activity by Colorimetric Method and IL-1β content in synovial cells of each group by ELISA.ResultsIn the model group， compared with the blank group， the expressions of NALP6 mRNA， NALP6 and NF-κB proteins were up-regulated， while the expression of IκB protein was down-regulated. Caspase-1 activity and IL-1β content were increased（all P<0.05）. In the treatment group， compared with the model group， the serum containing TCM compound could significantly inhibit the expressions of NALP6 mRNA， NALP6 and NF-κB proteins， inhibit the activity of Caspase-1， reduce the content of IL-1β， and stimulate the expression of IκB protein in fibroblast synovial cells（all P<0.05）.ConclusionBlocking the “NALP6-Caspase-1-IL-1β” inflammatory signal pathway may be one of the most important mechanisms for preventing and treating the gouty arthritis through tonifying the kidney and disinhibiting dampness therapy.关键词：gouty arthritis;tonifying the kidney and disinhibiting dampness therapy;NALP6;fibroblast-like synoviocyte;traditional Chinese herbal medicine research
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发布时间：2022-09-30 - 摘要：ObjectiveTo investigate the effect of Dachengqi Decoction on the expression of high mobility group protein B1 （HMGB1） and NOD-like receptor protein 3 （NLRP3） inflammasomes in mice with severe acute pancreatitis （SAP） model.MethodsMale C57BL/6 mice were randomly divided into a control group， a model group， and low， medium and high dose groups of Dachengqi Decoction， with 6 mice in each group. The control group was given intraperitoneal injection of 0.9% NaCl solution， and the rest mice were given intraperitoneal injection of caerulein and lipopolysaccharide to induce SAP model. Dachengqi Decoction was given to the low， medium and high dose groups by gavage at 0 h， 8 h and 16 h after the successful establishment of the model， respectively. After 18 h of modeling， the serum myeloperoxidase （MPO）， lactate dehydrogenase （LDH） and trypsin levels were detected by the kit. Serum levels of HMGB1， interleukin-1β （IL-1β） and interleukin-18 （IL-18） were detected by ELISA. After HE staining， the morphological changes of pancreatic tissue were observed under light microscope. Immunohistochemistry and Western blot analysis were used to detect the expression levels of P2X purinoceptor 7 （P2X7）， NLRP3， apoptosis-associated speck-like protein （ASC） and aspartate-specific cysteine protease 1 （Caspase-1） in pancreatic tissue.Results①The serum levels of HMGB1， IL-1β， IL-18， trypsin， LDH and MPO in the model group were higher than those in the control group （P<0.05）； Compared with the model group， the Dachengqi Decoction low dose group had lower level of serum trypsin （P<0.05）， and the medium and high dose groups had lower serum levels of HMGB1， IL-1β， IL-18， trypsin， LDH and MPO （P<0.05）. ②There were edema， hemorrhage and inflammatory necrosis in the pancreatic tissue of mice in the model group. Dachengqi Decoction could alleviate the above injuries and protect the pancreatic tissue. ③The Dachengqi Decoction medium and high dose groups could significantly inhibit the expression of upstream P2X7 and its components NLRP3， ASC and Caspase-1 of NLRP3 inflammasomes in SAP mice （P<0.05）.ConclusionDachengqi Decoction can effectively inhibit the expression of HMGB1， the activation of NLRP3 inflammasomes and the production of inflammatory factors， thus improving the pancreatic function of SAP model mice.关键词：severe acute pancreatitis;Dachengqi Decoction;high mobility group protein B1;NLRP3;mice model;classical representative famous prescription
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发布时间：2022-09-30 - 摘要：ObjectiveTo elucidate the beneficial effects of Tiaoxin Bushen Formula （TXBSF） on synapse loss and tau hyperphosphorylation in the prefrontal cortex （PFC） of Alzheimer’s disease （AD） model mice with presenilin 1/2 conditional double knockout （PS cDKO）.MethodsMice aged 3～3.5 months， half male and half female， were randomly divided into three groups： Wildtype group （WT， n=6）， PS cDKO group （cDKO， n=6）， and PS cDKO+TXBSF group （cDKO+TXBSF， n=6）. The mice in the WT and cDKO groups were continuously fed with standard chow， and mice in cDKO+TXBSF group were fed with TXBSF （2.55 g/kg）. After 90 days of treatment， Western blot analysis was used to evaluate the protein expression levels of synapse-associated proteins in the PFC of mice， such as N-methyl-d-aspartate receptor （NMDAR） subunits （NR1， NR2A， NR2B）， Microtubule associated protein-2 （MAP2） and tau hyperphosphorylation； qRT-PCR was used to detect the mRNA levels of synapse-associated proteins in the PFC of mice， including NR1， NR2A， NR2B， and MAP2.ResultsWestern blot results showed that compared with mice in cDKO group， mice in cDKO+TXBSF group had higher protein expression levels of synapse-related proteins （NR1， NR2A， NR2B and MAP2） （P<0.05） and lower expression level of p-tau （ser 396/404） （P<0.05）. The qRT-PCR analysis showed that compared with mice in cDKO group， mice in the cDKO+TXBSF group had higher mRNA levels of synapse-related proteins （NR1， NR2A， NR2B， and MAP2） in the PFC of mice （P<0.05）.ConclusionTXBSF has the potential to improve memory impairments in PS cDKO mice， which could be achieved by attenuating tau hyperphosphorylation and up-regulating expression of synaptic proteins in the PFC.关键词：Alzheimer’s disease;Tiaoxin Bushen Formula;prefrontal cortex;synapse loss;tau protein;mouse model;traditional Chinese herbal medicine research
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发布时间：2022-09-30 - 摘要：ObjectiveTo study the role of marein in mediating SIRT3/SREBP-1 signaling pathway to repair renal fibrosis in diabetic nephropathy （DN）.MethodsRats’ glomerular mesangial cells （HBZY-1） were induced by high glucose （HG） and palmitic acid （PA） to establish a DN model in vitro. The cells were divided into normal control group， model group and different dosage groups of marein. Inverted microscope was used to observe the changes in the number and morphology of cells in each group. Western blot was used to detect the expression levels of SIRT3/SREBP-1 pathway protein， fibrosis damage-related proteins transforming growth factor-β1 （TGF-β1）， p-Smad2， p-Smad3 and Smad4 in each group. Discovery studio was used to molecularly dock marein with silent information regulator 3 （SIRT3）. Immunofluorescence method was used to detect the expression and localization of fibronectin （FN） and Collagen Ⅳ of cells in each group.ResultsMarein inhibited the proliferation of HBZY-1 cells induced by HG and PA， which increased the intercellular and decreased the cell density. Marein down-regulated the expression of SREBP-1， TGF-β1， p-Smad2， p-Smad3 and Smad4 proteins in model cells. Marein up-regulated the expression of active SIRT3， and the molecular docking results showed that marein and SIRT3 protein binded well. Marein inhibited the expression of FN and Collagen Ⅳ protein in cells induced by HG and PA.ConclusionMarein may reduce the kidney inflammation and fibrosis damage induced by HG and PA in HBZY-1 cells by activating SIRT3 protein， mediating the SIRT3/SREBP-1 pathway and down-regulating the TGF-β1/Smads signaling pathway protein.关键词：diabetic nephropathy;renal fibrosis;marein;Coreopsis Tinctoria;pharmacologic effect;traditional Chinese herbal medicine
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发布时间：2022-09-30 - 摘要：Peucedani Radix in the Umbelliferae family as one of the major traditional Chinese medicinal materials （TCMMs） contains coumarins， organic acids， sterols， volatile oils and other chemical components. Coumarins are recognized as the main bioactive constituents responsible for its effectiveness， and play a positive role in relieving cough and asthma， strengthening the heart function， as well as preventing and treating cardiovascular diseases. With the increasing attention paid to traditional Chinese medicine （TCM） in the post-pandemic environment and the progressive research on traditional Chinese herbal medicines （TCHMs）， Peucedani Radix and the coumarin-like components have occupied certain domestic and international markets and are gradually being developed and exploited. In this paper， we reviewed the research progress of coumarin-like chemical components in Peucedani Radix， as well as their analytical methods and pharmacological effects， aiming to provide reference for the quality evaluation， pharmacological and efficacy research of Peucedani Radix and new drug development of coumarins in Peucedani Radix.关键词：Peucedani Radix;coumarins;chemical composition;quality evaluation;pharmacological effect;traditional Chinese herbal medicines research;review
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发布时间：2022-09-30 - 摘要：The research progress on anti-hepatic cancer mechanism of Scutellariae Barbatae Herba is reviewed. The main chemical components of Scutellariae Barbatae Herba are flavonoids， diterpenoids， polysaccharides， and volatile oils， etc， which have many biological effects. Its mechanism includes inhibiting cell proliferation， blocking cell cycle， inducing apoptosis andautophagy， inhibiting tumor metastasis and tumor angiogenesis， as well as enhancing immunity and chemotherapeutic effects.关键词：hepatic cancer;Scutellariae Barbatae Herba;mechanism of action;research progress;research of traditional Chinese medicine
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发布时间：2022-09-30 - 摘要：This paper reviewed the research progress on the mechanism of traditional Chinese medicine on pulmonary disease / hypoxia induced pulmonary hypertension. It was found that there were multiple molecular signaling pathways to promote pulmonary vasoconstriction and pulmonary vascular remodeling， including hypoxia inducible factor / transient receptor potential canonical （TRPC）， mitogen activated protein kinases（MAPK）， Rho / Rho kinase （ROCK）， phosphatidylinositol 3-kinase / protein kinase B （PI3K/AKT）， bone morphogenic protein/ transforming growth factor β（BMP / TGF-β）， nuclear factor kappa-B （NF-κB）. Traditional Chinese medicine compound， traditional Chinese medicine extract and Chinese patent medicine could inhibit multiple signal pathways， inhibit pulmonary vascular remodeling and delay the process of pulmonary hypertension.关键词：pulmonary hypertension;chronic obstructive pulmonary disease;traditional Chinese herbal medicine;signal path;pharmacologic effect;research progress
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发布时间：2022-09-30
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