最新刊期
期 2 ， 2022
- 摘要：Lower limb chronic ulcer （ecthyma） is a common and frequently-occurring disease in the Department of Peripheral Vascular Diseases. It often occurs in the lower limbs， and is usually accompanied by a history of varicose veins in the lower limbs. The ulcer is difficult to heal， or it recurs due to injury after recovery， causing intractability in the clinical practice. The various internal and external treatments of traditional Chinese medicine （TCM） have unique advantages and remarkable efficacy in treating the lower limb chronic ulcer. Professional Committee on Peripheral Vascular Disease of Shanghai Association of Integrative Medicine organized domestic experts in the field of peripheral vascular diseases to form an expert consensus on TCM diagnosis， treatment and efficacy evaluation of the lower limb chronic ulcer so as to provide reference for the clinical diagnosis， treatment and scientific research work.关键词：lower limb chronic ulcer;traditional Chinese medicine diagnosis;traditional Chinese medicine treatment;efficacy evaluation standard;expert consensus
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发布时间：2022-07-10 - 摘要：According to traditional Chinese medicine （TCM） theory， the pathogenic characteristics of chemotherapy-induced thrombocytopenia （CIT） are summarized under the guidance of holistic concept and syndrome differentiation-based treatment， taking the deficiency of liver， spleen and kidney as the root， fire-exuberance and heat-toxin as the manifestation， and internal stagnation of blood stasis as the critical change. The therapeutic countermeasures are provided correspondingly. The method of invigorating spleen and nourishing liver is adopted to produce blood， the method of purging fire and removing toxicity is used to treat the symptoms and the method of activating blood and dispelling stasis is for the treatment of manifestation. Treating methods should be adjusted as the condition changes to achieve therapeutic effects. A proved case is attached for verification.关键词：tumor;chemotherapy;thrombocytopenia;traditional Chinese medicine pathogenesis;oral intake of a traditional Chinese medicine decoction;syndrome differentiation-based treatment
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发布时间：2022-07-10 - 摘要：ObjectiveTo explore the medication rules of traditional Chinese medicine （TCM） prescriptions for hyperprolactinemia （HPRL）， extract the core prescriptions， and preliminarily seek the relevant mechanisms based on text mining and bioinformatics methods， in order to guide the clinical treatment.MethodsThe literatures of TCM cases and clinical research on the treatment of HPRL were searched from China National Knowledge Infrastructure （CNKI）， WanFang Database （WangFang） and VIP Database （VIP）. The TCM syndrome types of HPRL， the nature， flavor and channel tropism of medicines， the rules of prescription and dosage and the prescription characteristics were analyzed， and the core herbs and prescriptions were mined through TCM Inheritance Auxiliary Platform. The effective targets and mechanisms of core prescriptions were analyzed by bioinformatics methods.ResultsA total of 75 cases with complete prescriptions were screened and input involving 75 relevant prescriptions and 147 Chinese medicinal herbs. The main TCM syndrome of HPRL was liver stagnation and kidney deficiency syndrome， the nature and flavor of the Chinese medicinal herbs were mostly warm， flat， sweet， bitter and spicy， and the Chinese medicinal herbs mainly belonged to the liver， spleen and kidney channels. The dosage of raw barley germinating fruit in treating HPRL was mostly 60 g. The high-frequency Chinese medicinal herbs included root of common peony， root of Chinese angelica， root of Chinese thorowax， raw barley germinating fruit， Indian bread， root of ural licorice and so on， and 40 relevant herb groups were obtained. The extracted core prescription was modified Xiaoyaosan Decoction， and could be used to treat HPRL through 28 target proteins involving 928 biological processes and 36 signaling pathways. The key therapeutic effects were closely related to the PI3K-Akt signaling pathway， JAK-STAT signaling pathway， VEGF signaling pathway， Th17 cell differentiation signaling pathway， and dopaminergic neurosynaptic conduction pathway.ConclusionThe therapeutic method of TCM on HPRL is mainly soothing liver， strengthening spleen and nourishing kidney， which could be summarized as the regulation of three internal organs. The nature and flavour of herbs is sweet， warm and mild. The core prescription is based on Xiaoyaosan Decoction， and the analysis of bioinformatics method shows that each herb in the core prescription can effectively act on HPRL， which has potential guidance value for TCM in treating HPRL.关键词：hyperprolactinemia;lactorrhea;Xiaoyaosan Decoction;text mining;traditional Chinese herbal medicine research;biological information
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发布时间：2022-07-10 - 摘要：The purpose of this paper is to summarize Professor Liu Ping’s clinical experience in the treatment of insomnia with liver cirrhosis based on the theory of “liver storing soul”. It is considered that the basic pathogenesis of insomnia with liver cirrhosis is deficiency of yin and blood of the live and failure of the liver to storing soul. Hence， the basic therapy is enriching yin and nourishing blood as well as clearing heat， and the prescription used is the decoction of modified Yiguanjian. And one proven case is presented.关键词：insomnia;liver cirrhosis;liver storing soul;enriching yin and nourish blood;Yiguanjian;traditional Chinese medicine therapy
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发布时间：2022-07-10 - 摘要：The purpose of this paper is to introduce Professor Xu Lianwei's experience in treating infertility caused by polycystic ovary syndrome （PCOS） with Wuzi Yanzong Pill. Professor Xu Lianwei believes that Wuzi Yanzong Pill not only has the effect of tonifying the kidney and replenishing essence， but also can replenishes the yin， yang， qi and blood of the liver and kidney， which is suitable for PCOS infertility. It is also analyzed about the drug composition and the experience of adding and subtracting drugs in prescribing the prescription. And one proven case is presented．关键词：infertility;polycystic ovary syndrome;Wuzi Yanzong Pill;traditional Chinese medicine therapy
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发布时间：2022-07-10 - 摘要：This paper introduces the clinical experience of applying Guizhi Fuling Pill combined with other prescriptions in the treatment of miscellaneous diseases. They are the cases of frequent micturition treated with Guizhi Fuling Pill and Sini San， the cases of unhealing ulcer of dorsum of foot treated with Guizhi Fuling Pill and Siwei Jianbu Decoction， the cases of lip numbness treated with Guizhi Fuling Pill and Dachaihu Decoction， the cases of ardor urinae treated with Guizhi Fuling Pill and Zhuling Decoction and the cases of feverish sensation over the palm and sole treated with Guizhi Fuling Pill and Sanwu Huangqin Decoction. It is considered that the differentiation and treatment of the diseases should be combined with constitution of the patients and by the method of correspondence between prescriptions and syndromes.关键词：frequent micturition;unhealing ulcer;lip numbness ardor urinae;feverish sensation over the palm and sole;Guizhi Fuling Pill;traditional Chinese medicine therapy
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发布时间：2022-07-10 - 摘要：Based on the cause of disease， this paper explored the concept， nature and pathogenic characteristics of endogenous hidden pathogen， and analyzed the relationship between endogenous hidden pathogen and causes of disease and pathogenesis of part of the clinical intractable diseases. On this basis， it was put forward that the clinical treatments of the diseases induced by endogenous hidden pathogens were adjusting the functions of zang-fu and meridian， strengthening and consolidating body resistance， regulating the metabolism of qi， blood and fluid， coordinating the nature of hidden pathogens， and guiding the hidden pathogens to transform into vital qi eventually.关键词：endogenous hidden pathogen;concept;pathogenic characteristics;treatment ideas
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发布时间：2022-07-10 - 摘要：ObjectiveTo explore the distribution of traditional Chinese medicine （TCM） syndromes in patients with colorectal precancerous lesions， and follow up their recurrence rate and canceration rate.MethodsThe patients with colorectal precancerous lesions admitted to Changzheng Hospital affiliated to Naval Military Medical University from January 2010 to December 2015 were enrolled as the research objects， and their baseline conditions （pathological type， gender， age， adenoma location and size， etc.）， TCM syndrome differentiation， recurrence rate and canceration rate were analyzed retrospectively.Results①In the course of study， a total of 316 effective cases were collected. Among them， there were 217 cases of low-grade intraepithelial neoplasia （LGIN） and 99 cases of high-grade intraepithelial neoplasia （HGIN）； there were slightly more males （58.54%） than females （41.46%）； the age range of most patients was from the age of 40 to 60 （65.82%）； precancerous lesions mostly occurred in the left colon （73.42%）； most tumors were less than 2 cm in size （86.08%）. ②There were 73 cases of spleen deficiency and qi stagnation syndrome， 86 cases of damp-heat accumulation and binding syndrome， 85 cases of excessive phlegm-turbidity stagnation syndrome， 37 cases of yang deficiency and cold coagulation syndrome， and 35 cases of blood stasis syndrome. ③The results of TCM syndrome differentiation showed that the cases with damp-heat accumulation and binding syndrome and excessive phlegm-turbidity stagnation syndrome accounted for 27.22% and 26.90% respectively， followed by cases with spleen deficiency and qi stagnation syndrome （23.10%）. In the LGIN group， the cases with spleen deficiency and qi stagnation syndrome （27.65%） and damp-heat accumulation and binding syndrome （27.65%） were in the majority； In the HGIN group， the cases with excessive phlegm-turbidity stagnation syndrome accounted for 32.32%， which was the highest proportion， followed by the cases with damp-heat accumulation and binding syndrome， which accounted for 26.26%. ④In the LGIN group， cases with the damp-heat accumulation and binding syndrome had the highest 5-year recurrence rate （61.67%）， followed by the cases with yang deficiency and cold coagulation syndrome （58.33%）， excessive phlegm-turbidity stagnation syndrome （56.6%） and spleen deficiency and qi stagnation syndrome （40.00%）， and cases with blood stasis syndrome had the lowest 5-year recurrence rate （35.00%）. In the HGIN group， cases with the blood stasis syndrome had the highest 5-year recurrence rate （80.00%）， followed by cases with damp-heat accumulation and binding syndrome （69.23%）， excessive phlegm-turbidity stagnation syndrome （62.50%）， spleen deficiency and qi stagnation syndrome （53.85%） and yang deficiency and cold coagulation syndrome （53.85%）. ⑤In terms of canceration rate， patients with canceration usually had excessive phlegm-turbidity stagnation syndrome， damp-heat accumulation and binding syndrome or blood stasis syndrome， and the canceration rates of each syndrome were 9.38%， 6.67% and 3.85% respectively.ConclusionsPatients with colorectal precancerous lesions mostly have damp-heat accumulation and binding syndrome， excessive phlegm-turbidity stagnation syndrome or spleen deficiency and qi stagnation syndrome. Phlegm-turbidity， damp-heat and blood stasis are not only pathological products， but also important pathogenic factors leading to the recurrence and canceration of colorectal precancerous lesions， which should be paid special attention to in clinical practice.关键词：colorectal cancer;precancerous lesion;adenomatous polyp;after colonoscopic resection;TCM syndrome;recurrence;prognostic outcome
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发布时间：2022-07-10 - 摘要：ObjectiveTo observe the short-term efficacy of Kangliu Jiandu Recipe on patients with non-small cell lung cancer （NSCLC） undergoing chemotherapy and its effect on serum vascular endothelial growth factor （VEGF） level.MethodsSeventy patients with NSCLC were randomly divided into the treatment group and control group， 35 cases in each group. The control group was treated with simple chemotherapy （TP scheme）， and the treatment group was treated with Kangliu Jiandu Recipe on the basis of chemotherapy. Twenty eight days were taken as one course of treatment， and a total of two courses were performed. The short-term efficacy of the two groups were observed， the change of serum VEGF level was compared， and the effects of the two therapy schemes on hematopoietic function， liver and kidney function and gastrointestinal function were compared.Results①During the trial， 5 cases in the treatment group and 5 cases in the control group fell off， finally 60 cases completed the trial， including 30 cases in the treatment group and 30 cases in the control group. ②The disease control rates of the treatment group and the control group were 93.33% and 70.00% respectively. The short⁃term efficacy of the treatment group was better than that of the control group （P<0.05）. ③Compared with that before treatment， the serum level of VEGF was decreased in the treatment group but increased in the control group （P<0.05）. After treatment， there was no statistically significant difference in serum VEGF level between the two groups （P>0.05）. ④The incidence rates of nausea， vomiting and leucopenia in the treatment group were lower than those in the control group （P<0.05）. There was no statistically significant difference in the incidence of adverse reactions related to liver and kidney function between the two groups （P>0.05）.ConclusionKangliu Jiandu Recipe can effectively improve the efficacy of NSCLC patients undergoing chemotherapy， reduce the serum level of VEGF and alleviate the toxic and side reactions of chemotherapy drugs.关键词：non-small cell lung cancer;Kangliu Jiandu Recipe;chemotherapy;vascular endothelial growth factor;reducing toxicity and enhancing efficiency;clinical trial
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发布时间：2022-07-10 - 摘要：ObjectiveTo observe the clinical efficacy of external application of Longteng Tongluo Decoction （LTD） in the treatment of oxaliplatin-induced peripheral neuropathy （OIPN）.MethodsTotally 120 patients with OIPN were randomly divided into a treatment group， a placebo group and a control group， with 40 cases in each group. The treatment group was administered with LTD for external application， the placebo group was administered with LTD placebo for external application， and the control group was administered with methylcobalt for oral administration. The treatment lasted 28 days in each group. The clinical efficacy was observed， and the changes in peripheral neurotoxicity grading， quality of survival （FACT/GOG-Ntx scale score， EORTC QOL C30 v3.0 scale score）， TCM syndrome scores and serum nerve growth factor （NGF） levels were compared， and safety evaluation was also performed.Results①In the treatment group and placebo group 4 cases dropped out or were removed， and there was 1 drop-out case in the control group. Finally， 36 cases each in the treatment group and placebo group and 39 cases in the control group completed the trial. ②On peripheral neurotoxicity grading： the total effective rates of the treatment group， placebo group and control group were 72.22%， 16.67% and 35.90%， respectively. The efficacy of the treatment group was better than that of the placebo group and control group （P<0.01）. There was no significant difference in the efficacy between the placebo group and the control group （P>0.05）. On TCM syndrome scores： the total effective rates of the treatment group， placebo group and control group were 72.22%， 36.11% and 33.33%， respectively， and the efficacy of the treatment group was better than that of the placebo group and control group （P<0.01）. There was no significant difference in the efficacy between the placebo group and the control group （P>0.05）. ③The improvement in the peripheral neurotoxicity grading was observed after 7 days of treatment in the treatment group （P<0.05）， after 21 days of treatment in the placebo group （P<0.05）， and after treatment in the control group （P<0.05）. There was no statistically significant difference in peripheral neurotoxicity grading among three groups after 7 days and 14 days of treatment （P>0.05）. After 21 days of treatment， the peripheral neurotoxicity grading of the treatment group was better than that of the placebo group （P<0.05）， but there was no statistically significant difference in the peripheral neurotoxicity grading between the treatment group and the control group， and between the control group and the placebo group （P>0.05）. After 28 days of treatment， the peripheral neurotoxicity grading of the treatment group was better than that of the placebo group and the control group （P<0.01）， and there was no statistically significant difference in the peripheral neurotoxicity grading between the placebo group and the control group （P>0.05）.④According to the intra-group comparison before and after treatment， the scores of palpitation and shortness of breath， fatigue， spontaneous sweating， dizziness， insomnia and forgetfulness， and numbness of hands and feet decreased in the treatment group （P<0.05）， the scores of palpitation and shortness of breath， insomnia and forgetfulness dropped in the placebo group （P<0.05）， the scores of numbness of hands and feet decreased in the control group （P<0.05）. According to the inter-group comparison after treatment， no significant differences were found in the scores of dizziness， insomnia and forgetfulness among the three groups （P>0.05）； the scores of palpitation and shortness of breath， spontaneous sweating and numbness of hands and feet in the treatment group were lower than those in the control group （P<0.05， P<0.01）， and the scores of fatigue and numbness of hands and feet in the treatment group were lower than those in the placebo group （P<0.05， P<0.01）； and the scores of palpitation and shortness of breath in the placebo group were lower than those in the control group （P<0.01）. ⑤The intra-group comparison before and after treatment showed that the FACT/GOG-Ntx scale scores decreased in each group （P<0.05）. After treatment， the FACT/GOG-Ntx scale scores in the treatment group were lower than those in the control group and placebo group （P<0.05， P<0.01）， and there was no statistically significant difference in the FACT/GOG-Ntx scale scores between the control group and placebo group （P>0.05）. ⑥According to the intra-group comparison， the scores of the 5 functional scales （physical， role， cognitive， emotional， and social function） and the total health status scores increased in the treatment group （P<0.05）， the scores of physical， role and cognitive function and the total health status scores increased in the placebo group （P<0.05）， and only the scores of role function and the total health status scores increased in the control group （P<0.05）. After treatment， the differences in scores of cognitive function and social function were not statistically significant （P>0.05）； the scores of emotional， physical and role function and the total health status scores in the treatment group were higher than those in the placebo group （P<0.05， P<0.01）， and the scores of role function and the total health status scores in the treatment group were higher than those in the control group （P<0.05， P<0.01）. The differences in the scores of each subscale of the EORTC QOL C30 v3.0 scale were not statistically significant between the control group and the placebo group （P>0.05）. ⑦The differences in serum NGF levels were not statistically significant when compared within and between groups before and after treatment （P>0.05）.ConclusionLongteng Tongluo Decoction can effectively improve the clinical symptoms of OIPN and the quality of survival of patients with better safety.关键词：tumor;chemotherapy;oxaliplatin;peripheral neuropathy;Longteng Tongluo Decoction;external treatment of traditional Chinese Medicine;clinical trial
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发布时间：2022-07-10 - 摘要：ObjectiveTo observe the clinical efficacy of oral administration of modified Linggui Zhugan Decoction combined with external application of Xiaoshui Recipe in treating lung cancer with pleural effusion.MethodsSixty-four patients of lung cancer with pleural effusion were randomly divided into the treatment group and control group， 32 cases in each group. The control group was treated with conventional western medicine， and the treatment group was treated with Linggui Zhugan Decoction by oral administration and Xiaoshui Recipe by external application based on the treatment for the control group. The treatment course was 7 days in both groups. The clinical efficacy was observed， the changes of Chinese medical syndrome scores， immune indexes， inflammatory factors and tumor indexes were compared， as well as the puncture and drainage of pleural effusion and the use of diuretics.Results①During the trial， two cases in the treatment group and two cases in the control group fell off， finally 60 cases completed the trail， among 30 cases in the treatment group and 30 cases in the control group. ②The total effective rates of the treatment group and the control group were 86.7% and 60.0% respectively. The clinical efficacy of the treatment group was better than that of the control group （P<0.05）. ③Compared with those before treatment， the total score of Chinese medical syndrome and the scores of cough， shortness of breath， chest tightness and mental fatigue were decreased in the treatment group after treatment （P<0.05）， while the total score of Chinese medical syndrome and the score of shortness of breath were increased in the control group （P<0.05）. After treatment， the total score of Chinese medical syndrome and the scores of cough， shortness of breath， chest tightness and mental fatigue in the treatment group were lower than those in the control group （P<0.05）. ④Compared with those before treatment， the levels of CD3+ and CD4+ in peripheral blood were increased and the levels of interleukin-2 （IL-2）， interleukin-6 （IL-6）， interleukin-8 （IL-8）， malignant tumor specific growth factor （TSGF） and carcinoembryonic antigen （CEA） were decreased in the treatment group （P<0.05）， but there were no statistically significant differences on the immune， tumor and inflammatory factors in the control group after treatment （P>0.05）. After treatment， the levels of CD3+ and CD4+ in the treatment group were higher than those in the control group， and the levels of IL-2 and IL-6 in the treatment group were lower than those in the control group （P<0.05）. ⑤The rate of pleural effusion puncture and drainage in the treatment group was lower than that in the control group （P<0.05）， and there was no statistically significant difference in the use of diuretics between the two groups （P>0.05）.ConclusionOral administration of modified Linggui Zhugan Decoction combined with external application of Xiaoshui Recipe shows good efficacy in treating lung cancer with pleural effusion， which can effectively reduce pleural effusion and improve the clinical symptoms of patients.关键词：lung cancer;pleural effusion;Linggui Zhugan Decoction;Xiaoshui Recipe;external application of Chinese medicine;clinical trial
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发布时间：2022-07-10 - 摘要：ObjectiveTo observe the clinical effect of Sanjie Tongluo Granule combined with western medicine on the treatment of bone metastases （BMs） of malignant tumor.MethodsSeventy patients with BMs of malignant tumor were randomly divided into treatment group （n=35） and control group （n=35）. The control group was administered with conventional western medicine， while the treatment group was administered with Sanjie Tongluo Granule besides the conventional treatment measures of the control group. The course of treatment in both groups was 6 months. We observed the clinical effect， progression-free survival （PFS） and medication safety， and compared the changes in scores of related indicators including numerical rating scale （NRS） for pain， serum calcium （Ca2+）， alkaline phosphatase （ALP）， serum tumor markers， immune function， TCM syndrome， and quality of life scale.Results①Finally， 33 cases in the treatment group and 33 cases in the control group completed the trial. ②According to the result of inter-group comparison， the treatment group showed significantly better treatment effect than the control group （P<0.05）； The average and median PFS in the treatment group were significantly higher than those in the control group （P<0.05）. ③The pain NRS score in the treatment group was significantly lower than that in the control group （P<0.05）； The duration of pain relief was significantly longer and the dosage of oxycodone in 24 hours was significantly lower in the treatment group than those in the control group （P<0.05）. ④After treatment， the ALP level in the treatment group was significantly lower than that in the control group （P<0.05）. ⑤After treatment， the levels of CA15-3 and CEA in the treatment group were significantly lower than those in the control group （P<0.05）. ⑥After treatment， the levels of CD3+ and CD4+ in the treatment group were significantly higher than those in the control group （P<0.05）. ⑦After treatment， the TCM syndrome scores in the treatment group were significantly lower than those in the control group （P<0.05）. ⑧After treatment， the scores of pain location， dysfunction and social psychological modules of the quality of life scale in the treatment group were significantly lower than those in the control group （P<0.05）.ConclusionSanjie Tongluo Granule combined with western medicine has achieved more satisfactory clinical effect than western medicine alone in treating bone metastases of malignant tumor.关键词：malignant tumor;bone metastasis;metastatic bone tumor;intermingled phlegm and blood stasis syndrome;Sanjie Tongluo Granule;bone metastasis pain;progression-free survival;integrated traditional Chinese and western medicine
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发布时间：2022-07-10 - 摘要：ObjectiveTo explore the mechanism of anti-colorectal cancer activity of Canmei Formula at the transcriptome level by second generation sequencing.MethodsMume Fructus and Bombyx Batryticatus， the core drugs for the treatment of intestine wind from the Compendium of Materia Medica， were selected to compose of Canmei Formula and to interfere with RKO cells （intestinal cancer cells）. The control group（RKO-Control）and the experimental group （RKO-treatment）were sequenced by the second generation high-throughput sequencing platform （IlluminaHi-Seq）， and the biological function enrichment analysis was carried out by using gene ontology （GO） and Kyoto encyclopedia of genes and genomes （KEGG）. Molecular docking methods was used to verify the binding effect of active ingredients with key targets. Results The number of differential genes was 2 516， including 1 279 up-regulated genes and 1 237 down-regulated genes. Three core differential genes related to colorectal cancer， FOXD1， FBLN2 and LDLRAD2， were screened. GO analysis showed that the differential genes were mainly involved in single-organism metabolic process， cell cycle and response to organic substance， while KEGG analysis showed that differentially expressed genes were mainly involved in metabolic pathway， cell cycle and RNA transport. Molecular docking results preliminarily verified that the main active components of Canmei Formula had high affinity with core targets.ConclusionCanmei Formula may play a role in anti-colorectal cancer from the aspects of gene transcriptional expression， cell metabolism and apoptosis through multi-target and multi-pathway.关键词：Canmei Formula;colorectal cancer;transcriptomics;metabolic pathway;high-throughput sequencing platform;traditional Chinese herbal medicine research
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发布时间：2022-07-10 - 摘要：ObjectiveStudy the effect of different doses of Wuzhuyu Decoction on cisplatin induced chemotherapy-related vomiting and intestinal mucositis in rats， and further explore its mechanism.MethodsThe active components of Wuzhuyu Decoction were identified by time-of-flight high-resolution mass spectrometry. Totally 48 SD rats were randomly divided into the control group， the model group， the different concentrations of Wuzhuyu Decoction groups （5，10，20 mL/kg） and the positive control group（tolansetron group），with 8 rats in each group. The heterophilic kaolin rats was observed on the 1st， 3rd， 5th and 7th day after modeling. The concentration of serum 5-hydroxytryptamine （5-HT） rats in each group was quantified by liquid chromatography-mass spectrometry （LC/MS）， and the changes of colonic tissue and the expression of γ-H2AX and CD45 were observed by HE staining and immunofluorescence.ResultsEvodiamine and rutaecarpine are the main components of Wuzhuyu Decoction. After treatment， compared with the model group， the amount of heterophilic kaolin and the concentration of serum 5-HT in the high and medium dose groups of Wuzhuyu Decoction decreased significantly （P<0.01）， and the pathomorphological observation showed that the high and medium dose groups of Wuzhuyu Decoction had protective effect on rat colonic mucosa and decreased the expression of γ-H2AX and CD45 （P<0.01）.ConclusionWuzhuyu Decoction can treat cisplatin-induced vomiting and reduce intestinal inflammation in rats， and its mechanism may be related to reducing the concentration of 5-HT in serum and inhibiting the expression of γ-H2AX and CD45 in intestinal tract.关键词：Wuzhuyu Decoction;chemotherapy induced nausea and vomiting;5-HT;γ-H2AX;CD45;model rat;traditional Chinese herbal medicine research
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发布时间：2022-07-10 - 摘要：ObjectiveTo elucidate the effect and mechanism of Yiqi Fuzheng Prescription in regulating the phenotypic transformation of tumor-associated macrophages （TAMs）.Methods①The model of M2 TAMs was established in vitro. The concentration of Yiqi Fuzheng Prescription was determined by CCK-8 experiment. The expression of M1 and M2 TAMs was identified by flow cytometry. The mRNA expression levels of CCL2， AMPK and mTOR were detected by RT-PCR， and Western blot was used to detect the expression of CCL2， AMPK and mTOR in TAMs. ②The subcutaneous transplanted tumor model of Lewis lung cancer in mice was established， and the proportion of M1 and M2 TAMs in each group was detected by flow cytometry.Results① Yiqi Fuzheng Prescription could down regulate the expression of M2 TAMs and up regulate the expression of M1 type TAMs in vitro； At the same time， Yiqi Fuzheng Decoction down regulated the mRNA expression of CCL2 and mTOR in M2 TAMs （P<0.001）， and up regulated the mRNA expression of AMPK （P<0.05）； Western blot showed that compared with the model group， the expressions of CCL2 and mTOR were down regulated and the expression of AMPK was up-regulated in the TCM group （P<0.001）. ②Animal experiments showed that Yiqi Fuzheng Prescription could inhibit the growth of Lewis lung cancer transplanted tumor in mice. The flow cytometry results of tumor cells showed that Yiqi Fuzheng Prescription could inhibit the expression of M2 TAMs， up regulate the expression of M1 TAMs in tumor tissues， and the difference was statistically significant （P<0.05）.ConclusionYiqi Fuzheng Prescription can inhibit the transformation of TAMs into the M2 phenotype， and it plays a role in regulating the expression of each signaling molecule in CCL2/AMPK/mTOR， an important signaling pathway of TAMs polarization， suggesting that Yiqi Fuzheng Prescription may intervene in the TAMs polarizationto inhibit tumor metastasis through regulating the signaling pathway CCL2/AMPK/mTOR.关键词：Yiqi Fuzheng Prescription;tumor-associated macrophages;lung cancer;model mouse;traditional Chinese herbal medicine research
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发布时间：2022-07-10 - 摘要：ObjectiveTo establish UPLC fingerprint of Dahuang Zhechong Pill， as well as pattern recognition， and provide ideas and references for the establishment of corresponding quality evaluation system.MethodsWaters Acquity UPLC HSS T3 column （2.1 mm×100 mm， 1.8 μm） was taken， and acetonitrile-0.2% formic acid solution with gradient elution was used as mobile phase. The detection wavelength switching procedure was optimized according to the peak sequence of the main components of various medicinal materials. The column temperature was 35 ℃，and the flow rate was 0.3 mL/min. The TCM chromatographic fingerprint similarity evaluation system （version 2012.1） was used to establish the control fingerprint of Dahuang Zhechong Pill and evaluate the similarity， and then ChemPattern chemometrics software （version 2017） was used for cluster analysis， principal component analysis （PCA）， partial least squares regression analysis （PLS） and pattern recognition.ResultsIn the fingerprint， 30 common peaks were confirmed. According to the chromatographic peak behavior， reference ion fragments in UPLC-ESI-QTOF-MS and literature information， 13 known components were identified and other common peaks were attributed. The similarity of samples from B， C， F and G manufacturers was more than 0.90. PLS analysis could clearly distinguish the differences of samples from different manufacturers. Amygdalin and several main components of Scutellariae Radix and Rhei Radix et Rhizoma were selected as strong characteristic peaks. The results of cluster analysis， PCA and PLS were mutually verified.ConclusionThe UPLC fingerprint of Dahuang Zhechong Pill shows good stability and repeatability. Combined with chemical pattern recognition method， it can quickly and accurately reflect the overall quality of Dahuang Zhechong Pill， which can provide the basis for its quality control and evaluation.关键词：Dahuang Zhechong Pill;ultra performance liquid chromatography;fingerprint;chemical pattern recognition;similarity evaluation;traditional Chinese herbal medicine research
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发布时间：2022-07-10 - 摘要：This article reviews the resistance mechanism of epidermal growth factor receptor （EGFR） targeted therapy for colorectal cancer and the research progress of traditional Chinese herbal medicines （TCHMs）. Molecular mutation of the EGFR signaling pathway and abnormal activation of the compensatory signaling pathway are the main mechanisms for the resistance to anti-EGFR therapy. TCHMs have shown an obvious advantage in reversing tumor drug resistance owing to their multi-targeting effects. A variety of traditional Chinese herbal medicines and their active components not only have direct anti-tumor effects， but also can enhance the sensitivity of anti-tumor drugs and inhibit tumor drug resistance when used in combination with targeted drugs， which therefore are worthy of further in-depth study.关键词：colorectal cancer;epidermal growth factor receptor;targeted therapy;tumor drug resistance;traditional Chinese herbal medicine research;review
- 16
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- 665
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- 0
发布时间：2022-07-10 - 摘要：This paper reviews the research progress on the specific mechanism of the antitumor effect of bufalin in recent years. The antitumor mechanism of bufalin is mainly reflected in the induction of tumor cell apoptosis， inhibition of tumor cell proliferation and tumor angiogenesis and so on. And the antitumor drugs derived from bufalin can optimize the antitumor effect of bufalin， and reduce side effects.关键词：bufalin;antitumor;mechanism of action;review
- 30
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- 607
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- 0
发布时间：2022-07-10 - 摘要：The purpose of this paper is to explore the advantages and potential prospects of combined therapy of Chinese and western medicine in the prevention and treatment of tumor recurrence and metastasis based on the analysis of the advantages and limitations of monotherapy in the prevention and treatment of tumor recurrence and metastasis as well as the advantages of combination of traditional Chinese and western medicine in the prevention and treatment of tumor recurrence and metastasis. It is concluded that traditional Chinese medicine combined with chemotherapy， targeted therapy， chemotherapy and targeted combination therapy and immunotherapy are superior to monotherapy， which can not only significantly decrease the drug side effects and improve the quality of life， but also more importantly prevent recurrence and metastasis and prolong the progression-free survival and overall survival of patients.关键词：tumor;recurrence and metastasis;Chinese medicine;western medicine;integrated Chinese and western medicine treatment;review
- 22
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- 688
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- 0
发布时间：2022-07-10 - 摘要：This review summarized current studies on how traditional Chinese medicine influenced epigenetic modifications in women with polycystic ovary syndrome （PCOS） during gestation. Studies suggested hyperandrogenic intrauterine environment associate with altered fetal epigenetic modification and placental structure and functions， which in turn caused changes of fetal programming and influences offspring’s health in their adulthoods. Traditional Chinese medicine provided a new target for disease prevention and treatment through reversing altered epigenetic modification induced by hyperandrogenic intrauterine environment in women with PCOS.关键词：polycystic ovary syndrome;placenta;epigenetics;intrauterine environment;traditional Chinese medicine therapy;review
- 15
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- 455
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- 0
发布时间：2022-07-10
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