最新刊期
期 11 ， 2022
- 摘要：ObjectiveTo evaluate the implementation effect of the national standard—Classification and Codes of Diseases and Patterns of Traditional Chinese Medicine （GB/T 15657—2021）—in China and discuss the problems in its implementation for the purpose of providing technical basis and suggestions for further promoting the implementation of the standard.MethodsA questionnaire survey was conducted from November to December 2021 on the implementation， application， and training of the new national standard—Classification and Codes of Diseases and Patterns of Traditional Chinese Medicine （GB/T 15657—2021）—in the TCM institutions of 27 provinces and municipalities directly under the central government， including Shanghai， Jiangsu， and Zhejiang. Literature analysis was also performed.ResultsIn this survey， 834 questionnaires were distributed and 834 valid questionnaires were returned， covering 242 hospitals in China， among which 73.02% were tertiary hospitals and 26.02% were secondary hospitals. According to the survey， 95.80% of the respondents reported that their hospitals had started to use the standard； 81.18% of the respondents believed that the terminology of the standard was more practical； 79.86% of the respondents thought that the classification of this standard was more practical； 84.65% of the respondents held that the doctors’ diagnosis had become more standard and accurate since the implementation of this standard； and 88.25% of the respondents believed that this edition of the standard met the needs of clinical diagnosis. By December 2021， National Administration of Traditional Chinese Medicine， National Health Commission of the People’s Republic of China， and National Healthcare Security Administration had all issued a document to announce the use of Classification and Codes of Diseases and Patterns of Traditional Chinese Medicine （GB/T 15657—2021）.ConclusionClassification and Codes of Diseases and Patterns of Traditional Chinese Medicine （GB/T 15657—2021） has reasonable classification criteria and scientific terminology， which transits smoothly from the previous edition， and its implementation facilitates doctors to make more standard and accurate diagnosis. It is recommended to further improve the system construction of the new edition of the standard in terms of publicity and implementation， monitoring and evaluation， and feedback mechanism.关键词：Classification and Codes of Diseases and Patterns of Traditional Chinese Medicine;new edition;standardization;classification of diseases;traditional Chinese medicine syndrome;terminology study;implementation effect evaluation
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发布时间：2022-11-12 - 摘要：Based on the ancient classics of traditional Chinese medicine （TCM） and modern medical literature， we summarize and analyze the overview of modern medical research， harmfulness， pathogenesis and current treatment dilemma of duodenogastroesophageal reflux disease （DGERD） in this article， and also discuss the TCM understanding and treatment strategies. DGERD involves the duodenum， stomach and esophagus， and is caused by the hypofunction of the above-mentioned organs and the synergistic movement disorder of the upper digestive tract. It has the characteristics of being influenced by both gastric and duodenal contents. The pathogenesis is complex， and its treatment concept is at odds with its pathogenesis. In TCM， the pathogenesis of DGERD is considered to be the qi movement disorder of the liver and gallbladder， and that of the spleen and stomach. Corresponding clinical treatment strategy was recorded in ancient classics， using acupuncture and moxibustion as a main approach， which provides new ideas for the treatment of DGERD.关键词：duodenogastroesophageal reflux disease;bile reflux;gastroesophageal reflux disease;acupuncture and moxibustion;therapeutic strategy
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发布时间：2022-11-12 - 摘要：ObjectiveTo explore the law of traditional Chinese medicine syndrome and treatment for congestive heart failure （CHF） in ancient literatures based on the data mining methods.MethodsThe medical records conforming to CHF diagnosis in ancient literatures from the databases including Chinese Medical Code （the fifth edition）， Chaoxing digital books， paper documents， etc were collected. The statistical analysis and data mining were carried out by R language and SPSS 25.0 software， and the analysis methods included frequency analysis， association analysis， co-occurrence analysis， factor analysis， cluster analysis， complex network analysis， etc.Results①The most common symptoms of CHF included asthma， cough， chest tightness， inability to lie down， shortness of breath， swollen feet and so on. The tongue image was mainly white coating and the pulse condition was mainly deep， thin and string pulse. The syndrome elements were mainly phlegm turbidity， fluid retention， yang deficiency， qi deficiency， yin deficiency and so on. ②The double-related symptoms mainly included asthma + cough， asthma + inability to lie down， asthma + shortness of breath， asthma + phlegm， asthma + swollen feet， inability to lie down + cough， asthma + chest tightness， etc， and the three associated symptoms were mainly asthma + inability to lie down + cough. ③Among disease nature elements， yang deficiency was most related to phlegm turbidity and fluid retention， qi deficiency was most related to phlegm turbidity， fluid retention and yin deficiency， and phlegm turbidity was most related to fluid retention and qi deficiency. Yang deficiency and fluid retention of disease nature elements were most related to lung， spleen and kidney of disease location elements. Phlegm turbidity and qi deficiency of disease nature elements were most related to heart， lung， spleen and kidney of disease location elements. Yin deficiency of disease nature elements was most related to heart of disease location elements. ④The core symptoms of yang deficiency and water flooding syndrome of CHF included swollen feet， cold limbs， ascites， swollen face， irritability， edema， spontaneous sweating， less urination， poor sleep， inability to lie down， and shortness of breath. The core symptoms of qi deficiency and phlegm turbidity syndrome included cough， phlegm， poor appetite， asthma， diarrhea， heartache， and poor sleep. The core symptoms of qi and yin deficiency syndrome included palpitations， coma， dizziness， constipation， fantod， less urination， weakness， poor sleep， and asthma， with soft pulse， rapid pulse， thin pulse， weak pulse， and so on according to the different degree of the disease. The core symptoms of qi deficiency and blood stasis syndrome included chest pain， chest tightness， heartache， poor appetite， asthma with moving， fatigue， shortness of breath， weakness， and less urination， with deep pulse， string pulse and weak pulse according to the different degree of the disease. ⑤The most commonly used Chinese medicines in the treatment of CHF included Proia， Aconiti Lateralis Radix Praeparata， Codonopsis Radix， Cinnamomi Cortex， Atractylodis Macrocephalae Rhizoma， Citri Reticulatae Pericarpium， Rehmanniae Radix Praeparata， Alismatis Rhizoma， etc. The main prescriptions included Jinkui Shenqi Pill， Jisheng Shenqi Pill， Tingli Dazao Xiefei Decoction， Zhenwu Decoction， Erchen Decoction， Gualou Xiebai Banxia Decoction， Sijunzi Decoction， Buzhong Yiqi Decoction， Tianwang Buxin Pill， etc.ConclusionThrough the data mining on medical records in ancient literatures， it can be seen that， the syndrome and treatment of CHF have certain laws and the therapeutic methods are multiple， which can provide an ancient literature evidence for clinical treatment.关键词：congestive heart failure;ancient literature;data mining;syndrome;prescription
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发布时间：2022-11-12 - 摘要：ObjectiveTo use data mining methods to analyze Professor Lu Jingen’s medication experience and prescription pattern of traditional Chinese medicine （TCM） in treating functional constipation and summarize treatment principles.MethodsThe cases of functional constipation treated by Professor Lu Jingen in Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine from January 2018 to January 2021 were collected. The prescription information was extracted with Microsoft Excel software， and data mining was performed with R language data analysis platform to analyze the use frequency， association rules and clustering of traditional Chinese herbal medicines （TCHMs）， and the correlation analysis was also performed.Results①A total of 261 TCM prescriptions were included， involving 129 TCHMs with a total frequency of 4，748 times. Fourteen TCHMs were used over 200 times， and TCHMs used more than 30 times were mainly categorized into deficiency-tonifying medicines， heat-clearing medicines， blood-activating and stasis-removing medicines， phlegm-resolving medicines， bowel-moistening medicines and qi-promoting medicines. ②Based on association rules and clustering analysis， two basic formulas were obtained， i.e.， formula No.1 was composed of Huangqi （Astragali Radix）， Baizhu （Atractylodis Macrocephalae Rhizoma）， Xuanshen （Scophulariae Radix）， Dihuang （Rehmanniae Radix）， Maidong （Ophiopogonis Radix）， Nanshashen （Adenophorae Radix） and Beishashen （Glehniae Radix）， and formula No. 2 was composed of Danggui （Angelicae Sinensis Radix）， Zhishi （Aurantii Fructus Immaturus）， Danshen （Salviae Miltiorrhizae Radix et Rhizoma）， Gualou （Trichosanthis Fructus）， Huomaren （Cannabis Fructus）， Laifuzi （Raphani Semen）， Jiegeng （Platycodonis Radix） and Gancao （Glycyrrhizae Radix et Rhizoma）； Two couplet medicines were obtained， i.e.， Kuxingren （Armeniacae Semen Amarum） – Yuliren （Pruni Semen）， and Honghua （Carthami Flos） – Taoren （Persicae Semen）； And two combinations of medicines were obtained， i.e.， Baihe （Lilii Bulbus） – Zhimu （Anemarrhenae Rhizoma） – Meiguihua （Rosae Rugosae Flos） – Shichangpu （Acori Tatarinowii Rhizoma）， and Dazao （Jujubae Fructus） – Huaixiaomai （Triticum aestivum L.） – Zhigancao （Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle） – Lingzhi （Ganoderma） – Taizishen （Pseudostellariae Radix）. ③The correlation analysis showed that the highly correlated couplet medicines were as follows： Honghua （Carthami Flos） – Taoren （Persicae Semen）， Nanshashen （Adenophorae Radix） – Beishashen （Glehniae Radix）， Baihe （Lilii Bulbus） – Zhimu （Anemarrhenae Rhizoma）， Dazao （Jujubae Fructus） – Huaixiaomai （Triticum aestivum L.）， and Meiguihua （Rosae Rugosae Flos） – Shichangpu （Acori Tatarinowii Rhizoma）.ConclusionsWhen treating functional constipation， Professor Lu Jingen takes invigorating qi and nourishing yin， dispersing lung and resolving turbidity as the general principles flexibly， chooses the methods of moving qi， activating blood， moistening bowels and calming mind， modifies individual prescription on the basis of “Yiqi Kaimi Formula” in clinical practice， and focuses on the use of TCHMs with the effects of supplementing qi， nourishing yin and invigorating spleen. Professor Lu’s clinical experience can provide ideas for clinical diagnosis and treatment of functional constipation.关键词：functional constipation;traditional Chinese medicine therapy;famous doctor’s experience;data mining;medication pattern
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发布时间：2022-11-12 - 摘要：The clinical experience of professor Fan Guanjie in the treatment of acute gouty arthritis by “eight methods of moving-definite sequence”. has been explored It considered that the main pathogenesis of this disease was spleen deficiency and dampness resistance， dampness heat and blood stasis. The treatment was clearing heat and dampness， strengthening the spleen， promoting blood circulation， removing blood stasis and relieving pain. The self-made formula of clearing heat， dampness and dredging collaterals was used， and the "eight methods" medicine string was added and subtracted in syndrome differentiation. And one proven case was presented.关键词：eight methods of moving-definite sequence;gouty arthritis;acute phase;traditional Chinese medicine therapy;famous doctor’s experience
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发布时间：2022-11-12 - 摘要：Sperm DNA damage is closely related to male infertility. According to the etiological analysis and syndrome differentiation， infection， tendon tumor （varicocele）， obesity and old age can trigger the production of turbid pathogen inside the body. Turbid pathogen may be an important pathological product bridging the high-risk cause of sperm DNA damage and sperm nucleus damage. Microscopic differentiation reveals that the turbid pathogen is the core pathogenesis of sperm nucleus damage. Huazhuo （turbidity-resolving） method of traditional Chinese medicine is an important measure to block sperm nucleus damage and prevent male infertility due to sperm DNA damage. A proven case is provided for exemplification.关键词：male infertility;turbid pathogen;sperm DNA damage;traditional Chinese medicine therapy
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发布时间：2022-11-12 - 摘要：This paper sorts out the current treatment situation of primary immune thrombocytopenia （ITP）， and according to the clinical reality， looks for the breakthrough point of ITP treatment in traditional Chinese medicine， and puts forward the decision-making ideas of ITP treatment in the integrative traditional Chinese and western medicine. Based on the standardized treatment of ITP in western medicine， combined with the accurate treatment based on syndrome differentiation of traditional Chinese medicine， the advantages are fostering strengths and avoiding weaknesses， even complementary. And two proven cases are presented.关键词：primary immune thrombocytopenia;idiopathic thrombocytopenic purpura;integrated Chinese and western medicine treatment;treatment based on syndrome differentiation;clinical experience
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发布时间：2022-11-12 - 摘要：Based on the theory of deficiency and excess， combined with clinical practice， it was considered that the pathogenesis of multiple system atrophy was deficiency in origin and excess in superficiality， and deficiency led to excess， and the comprehensive pathogenesis was deficiency of spleen and kidney， stagnation of liver qi and blockage of evil qi. The basic pathogenesis was deficiency of the kidney， deficiency of the spleen， stagnation of the liver qi， and internal obstruction of evil qi. Clinical treatment should follow the principle of strengthening the body resistance and eliminating pathogenic factors， tonifying deficiency and purging excess. Specific treatment should be tonifying the kidney and replenishing essence， strengthening the spleen and replenishing qi， strengthening the muscle and transforming the source， soothing the liver and relieving depression， regulating qi and blood， eliminating pathogenic factors based on syndrome differentiation， tonifying deficiency and purging excess. Clinical prescription selection and medication could refer to Roucong Rong Pill， Buzhong Yiqi Decoction， Chaihu Shugan Powder， Yueju Pill， Zhizi Chi Decoction.关键词：multiple system atrophy;deficiency and excess theory;pathogenesis;deficiency of spleen and kidney;stagnation of liver qi and blockage of evil qi
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发布时间：2022-11-12 - 摘要：Based on the tracing of traditional Chinese medicine theory and clinical observation，it was believed that the theory of “heart paralysis” in Neijing was closely related to the cardiovascular injury of rheumatoid arthritis. Combined with the connotation of the theory of “heart paralysis”， it was believed that the disorder of ying and wei was the key factor in the pathogenesis of cardiovascular injury in rheumatoid arthritis. At the same time，the correlation between the clinical manifestations of cardiovascular injury in rheumatoid arthritis and the syndrome of “pulse paralysis” and “heart paralysis” was analyzed. It was suggested that the treatment of rheumatoid arthritis complicated with cardiovascular injury could be done by “bao ci” the acupoint of Daling and harmonizing ying and wei method to improve heart and relieve paralysis as well as removing blood stasis and tonifying deficiency drugs， and less spicy-dry drugs to remove pathogenic factors.关键词：heart paralysis;rheumatoid arthritis;arthralgia;cardiovascular disease;traditional Chinese medicine therapy
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发布时间：2022-11-12 - 摘要：This paper expounded the clinical application of midnight-noon and ebb-flow doctrine in heart diseases， such as coronary heart disease， hypertension， heart failure， arrhythmia and other heart diseases from three aspects： midnight-noon ebb-flow doctrine and physiological rhythm of heart， pathological rhythm of heart diseases， and timing treatment of heart diseases ， so as to provide theoretical basis for timing treatment of heart diseases.关键词：heart diseases;midnight-noon and ebb-flow doctrine;circadian rhythm;timing therapy;therapy of traditional Chinese medicine;clinical application
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发布时间：2022-11-12 - 摘要：ObjectiveTo evaluate the efficacy and safety of Prof. Cai Gan’s treatment of chronic atrophic gastritis （CAG） in the real world.MethodsA total of 316 patients with CAG received Prof. Cai Gan’s traditional Chinese medicine （TCM） treatment （mainly based on Xinwei Decoction）for at least 6 months. TCM symptom scores after 2 and 4 weeks of treatment， as well as gastroscopy and gastric mucosa histopathology after 6 months of treatment were observed； the scores of MYMOP2， SAS and SDS before treatment were compared with those after 2 and 4 weeks of treatment， respectively； and the safety evaluation was also performed.Results①The total effective rate of TCM symptom was 95.8% after 2 weeks of treatment and reached 99.4% after 4 weeks of treatment. The improvement of TCM symptoms after 4 weeks of treatment was better than that after 2 weeks of treatment， and the difference was statistically significant （P<0.05）. ②The scores of MYMOP2， SAS and SDS were lower after 2 and 4 weeks of treatment than those before treatment （P<0.05）； The scores of MYMOP2， SAS and SDS after 4 weeks of treatment were lower than those after 2 weeks of treatment （P<0.05）. ③After 6 months of treatment， the gastroscopic pathological effective rate reached 71.2%， the total effective rate of pathological atrophy reached 54.8%， and that of pathological intestinal metaplasia reached 74.0%. ④No adverse reactions occurred during the treatment. There were no significant changes in the routine blood test， and the liver and kidney function test.ConclusionIn the real world， Prof. Cai Gan has achieved a satisfactory result in the treatment of CAG， as his therapy can significantly alleviate the indigestion symptoms of patients， effectively improve the pathological atrophy of gastric tissue and intestinal metaplasia in CAG patients with the prolongation of treatment， and simultaneously have good long-term safety.关键词：chronic atrophic gastritis;traditional Chinese medicine therapy;famous doctor’s experience;pathology;real world study
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发布时间：2022-11-12 - 摘要：ObjectiveTo explore the therapeutic effect and mechanism of Shi’s Diaoshang Ointment on improving synovitis in knee osteoarthritis （KOA）.MethodsForty male New Zealand rabbits were randomly divided into a blank group， a model group， an experimental group （Shi’s Diaoshang Ointment group） and a control group （compound Zijing Xiaoshang Ointment group）， with 10 rabbits in each group. The rabbits in the blank group were fed normally， and the rabbits in the other three groups were injected with a mixed solution of 4% papain and 0.03 mol/L L-cysteine （2∶1） at a dosage of 0.2 mL/kg on the 1st， 4th， 7th and 12th day respectively to make the synovitis model of the knee joint. After the model was successfully prepared， the rabbits were depilated around the right lower limb knee joint. In the experimental group： a 3 cm × 6 cm gauze was smeared with 2 mm thickness of Diaoshang Ointment and applied to the affected joints； In the control group： Compound Zijing Xiaoshang Ointment was cut into 3 cm × 6 cm pieces and applied to the affected joints； In the model group： a 3 cm × 6 cm gauze was coated with 2 mm thickness of Vaseline and applied to the affected joints； In the blank group： A medical gauze of the same size was applied to the corresponding joint， and then eight-character winding was used to wrap the joint with medical adhesive tape. The dressing was routinely applied for 5 hours every day for 14 consecutive days. The skin temperature of the right knee of experimental rabbits was monitored regularly during intervention. The inflammatory factors ［tumor necrosis factor-α （TNF-α）， interleukin-1β （IL-1β）， prostaglandin E2 （PGE2）］ in knee synovial fluid of rabbits were detected after 14 days of intervention. The pathological changes of synovial tissue were observed by HE staining， and the content of aquaporin-1 and 4 （AQP1， AQP4） was detected by immunofluorescence. Some rabbit knee joints were observed via nuclear magnetic resonance imaging （MRI）.ResultsThe ointment used in the experimental group was superior to compound Zijing Xiaoshang Ointment used in the control group in improving the time-effect relationship of knee skin temperature in synovitis rabbits. There was no significant difference in levels of TNF-α， IL-1β， PGE2 in synovial fluid between the experimental group and the control group （P>0.05）. There were significant differences in HE staining scores of pathological sections of synovium obtained from rabbits’ affected joints in four groups （P<0.05）. After intervention， the content of AQP1 and AQP4 in synovium decreased significantly； The differences in the content of AQP1 and AQP4 were significant between the control group and the model group and also between the experimental group and the model group （P<0.05）； There was no significant difference in the content of AQP1 between the control group and the blank group （P>0.05）； There was no significant difference in the content of AQP4 between the experimental group and the control group （P>0.05）. The articular cavity effusion in MRI images was less in the experimental group than that in other groups.ConclusionsShi’s Diaoshang Ointment had better time-effect relationship of improving skin temperature of affected knees of synovitis rabbits than compound Zijing Xiaoshang Ointment used in the control group. Shi’s Diaoshang Ointment can improve synovitis in KOA by improving skin temperature， reducing the expression of inflammatory factors in synovial fluid， lowering the content of AQP1 and AQP4 in synovial tissue of model rabbits， and reducing articular cavity effusion.关键词：knee osteoarthritis;knee synovitis;Shi’s Diaoshang Ointment;aquaporin;external therapy;TCM compound formula;mechanism research
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发布时间：2022-11-12 - 摘要：ObjectiveTo study the effect of Weichang’an on the expression of Rho guanosine triphosphatase activating protein 25 （ARHGAP25） in orthotopic xenografts of colon cancer in nude mice， and to explore the molecular mechanism of Weichang’an inhibiting the invasion and metastasis of colon cancer.MethodsThe orthotopic xenograft model was made by human colon cancer HCT-116 cells. The nude mice were randomly divided into empty vector group， ARHGAP25 overexpression group， empty vector + Weichang’an low concentration group and empty vector + Weichang’an high concentration group with 6 mice in each group. The body mass， volume and tumor inhibition rate of orthotopic xenografts were compared. The positive expression of ARHGAP25 was detected by immunohistochemistry， the expression of ARHGAP25 mRNA was detected by RT-PCR， and the protein expressions of ARHGAP25， matrix metalloproteinase-7 （MMP-7）， matrix metalloproteinase-9 （MMP-9）， E-box binding zinc finger protein 1 （ZEB1） and β-catenin （β-catenin） were detected by Western blot.ResultsThe rate of tumor formation in nude mice was 100%. The tumor inhibition rates of ARHGAP25 overexpression group， empty vector + Weichang’an low concentration group and empty vector + Weichang’an high concentration group were 88.03%， 22.79% and 51.48%， respectively. The weight of orthotopic xenografts in ARHGAP25 overexpression group was significantly lower than that in empty vector group （P<0.05）； the volume of orthotopic xenografts in ARHGAP25 overexpression group and empty vector + Weichang’an high concentration group was significantly smaller than that in empty vector group （P<0.05）. Compared with those in the empty vector group， the positive expression area of ARHGAP25 was significantly increased in ARHGAP25 overexpression group and empty vector + Weichang’an low concentration group （P<0.05）； the expression of ARHGAP25 mRNA was significantly up-regulated in ARHGAP25 overexpression group， empty vector + Weichang’an low concentration group and empty vector + Weichang’an high concentration group （P<0.05）； the expression of ARHGAP25 protein was significantly up-regulated （P<0.05）， while the expression of MMP-7， MMP-9， ZEB1 and β-catenin were significantly down-regulated （P<0.05） in ARHGAP25 overexpression group， empty vector + Weichang’an low concentration group and empty vector + Weichang’an high concentration group.ConclusionWeichang'an can inhibit the growth of orthotopic xenografts of colon cancer in nude mice， promote the expression of ARHGAP25， reduce the expression of epithelial-mesenchymal transition-related molecules including ZEB1， β-catenin， MMP-7 and MMP-9， restrict the invasion and metastasis of orthotopic colon cancer in nude mice.关键词：colon cancer;Weichang’an;ARHGAP25;epithelial-mesenchymal transition;tumor metastasis;traditional Chinese herbal medicine research
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发布时间：2022-11-12 - 摘要：ObjectiveTo study the effects of Pingchuan Recipe on high mobility group protein B1/Toll-like receptor 4 （TLR4）/nuclear factor-κB （NF-κB）， airway remodeling related factors IκB kinase family （IKKs） and transforming growth factor-β1 （TGF-β1） in asthmatic mice.MethodsThirty-two male Balb/c mice were randomly divided into 4 groups： blank group， model group， dexamethasone group， and Pingchuan Recipe group， with 8 mice in each group. The asthma model was established by intraperitoneal injection of ovalbumin （OVA） with aluminum hydroxide and aerosolized inhalation of 5% OVA. One hour after atomization on the same day， Pingchuan Recipe was administered by gavage for 14 days. Serum， bronchoalveolar lavage fluid （BALF） and lung tissues were collected from mice in each group after the last administration. HE staining was used to observe the histopathological changes in the lungs of mice. Immunohistochemical staining was used to observe the expression of HMGB1， TLR4 and NF-κB. The content of HMGB1， TLR4， TGF-β1 and IKKs in BALF and peripheral blood was determined by ELISA. The expression of HMGB1， TLR4， NF-κB and IKKs mRNA in lung tissues was detected by RT-PCR. The expression of HMGB1 and TLR4 proteins in lung tissues was detected by Western blot.ResultsCompared with the condition of the blank group， the model group had severe airway remodeling， increased expression of HMGB1， TLR4 and NF-κB， increased HMGB1， TLR4， TGF-β1 and IKKs secretion （P<0.05）， increased HMGB1， TLR4， NF⁃κB and IKKs mRNA expression （P<0.05）， and increased HMGB1 and TLR4 protein expression （P<0.05）. Compared with the condition of the model group， Pingchuan Recipe group had alleviated airway remodeling， significantly lower HMGB1， TLR4， TGF-β1 and IKKs secretion （P<0.05）， reduced HMGB1， TLR4， NF⁃κB and IKKs mRNA expression （P<0.05）， and decreased HMGB1 and TLR4 protein expression （P<0.05）.ConclusionPingchuan Recipe can reduce HMGB1， TLR4， NF-κB and IKKs mRNA expression， decrease IKKs and TGF-β1 secretion， lower HMGB1 and TLR4 protein expression， alleviate the inflammation of lung tissues， and improve the pathological changes of lung tissues in asthmatic model mice.关键词：asthma;Pingchuan Recipe;HMGB1/TLR4/NF-κB;IKKs;mouse model;traditional Chinese herbal medicine research
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发布时间：2022-11-12 - 摘要：The definition and research methods of metabolomics were explained. The advances in the application of metabolomics to the research of Renshen （Ginseng Radix et Rhizoma） were reviewed in terms of source identification， growth environment， harvesting time， processing methods and pharmacological activity. The problems and future development directions of metabolomics in the research of Renshen （Ginseng Radix et Rhizoma） were summarized to provide ideas for the in-depth research of Renshen （Ginseng Radix et Rhizoma）.关键词：Ginseng Radix et Rhizoma;ginsenosides;metabonomics;active ingredient;research progress;traditional Chinese herbal medicine research
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发布时间：2022-11-12 - 摘要：To review the mechanism of action of long non-coding RNA （lncRNA） in gastric cancer and the research progress of traditional Chinese medicine in the treatment of gastric cancer by regulating lncRNA. Studies have shown that lncRNAs affect the progression， diagnosis and treatment of gastric cancer at several levels， including epigenetic regulation， transcriptional regulation and post-transcriptional regulation. Chinese medicine monomers， such as polyphenols， flavonoids， terpenoids， saponins and alkaloids， target different lncRNA and exert anti-tumor effects by regulating the expression of cyclins in gastric cancer cells， inhibiting cell migration and invasion， regulating programmed cell death， reversing drug resistance of gastric cancer cells and other mechanisms.关键词：gastric cancer;traditional Chinese herbal medicine;long non-coding RNA;mechanism of action;research progress
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发布时间：2022-11-12 - 摘要：Acupotomy is different from traditional surgical treatment and acupuncture， but organically integrates the features of both therapies. Acupotomy is a minimally invasive treatment， which has the advantages of no irreversible damage to human tissues， no need for wound suturing， simple operation， short treatment duration， low incidence of infection， good efficacy， low cost， and high patient acceptance. Acupotomy has gradually become one of the important methods for clinical treatment of lateral epicondylitis （tennis elbow）. The etiology and pathogenesis of lateral epicondylitis， the mechanism of acupotomy treatment of lateral epicondylitis， as well as the application， summary and prospect of acupotomy in the clinical treatment of lateral epicondylitis are reviewed in this article.关键词：lateral epicondylitis;tennis elbow;acupotomy;minimally invasive treatment;clinical application;research progress
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发布时间：2022-11-12
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