最新刊期
期 1 ， 2022
- 摘要：Parkinson’s disease （PD） is a degenerative disease of the central nervous system that commonly affects the middle-aged and elderly people. It is necessary to develop a long-term treatment strategy as patients diagnosed with PD have an average life expectancy of 17 years. Moreover， PD progresses rapidly in the early stage， and no sufficient evidence has been provided to prove that there is a single treatment or drug that can slow down the progression. Therefore， it is more significant to standardize the treatment of early-stage PD. Traditional Chinese medicine （TCM） is one of the most frequently used therapies for early-stage PD， and recent clinical studies have confirmed the efficacy enhancing， toxicity reducing and neuroprotective effects of integrated traditional Chinese and western medicine in the treatment of early PD. The Neurology Branch of the Shanghai Association of Chinese Medicine invited Chinese experts in the field of Chinese and western medicine for the treatment of Parkinson’s disease to reach an expert consensus on the integrated traditional Chinese and western medicine treatment of early-stage Parkinson’s disease for the purpose of providing reference for clinicians in the clinical treatment of early-stage Parkinson’s disease.关键词：Parkinson’s disease;early stage;tremor syndrome;integrated traditional Chinese and western medicine;diagnosis and treatment;expert consensus
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发布时间：2022-09-26 - 摘要：Electroencephalogram （EEG） is a non-invasive technology to explore brain functional activities. Microstate is a relatively stable EEG topological map in a certain period of time. Different microstates of EEG are the results of different clustering activities of neurons， representing the consistent activation in the whole brain functional network at the sub-second level. This paper briefly introduces the concept of EEG microstate and its general analysis process and steps. It is proposed that EEG microstate analysis can， on the one hand， serve as an entry point for the study of the mechanism of acupuncture action and its acupoint specificity； on the other hand， through the conversion between microstate time series and electrical signals， the microstates closely related to the therapeutic effect of acupuncture can be converted into electrical stimulation signals， thus proposing an optimal pathway for the selection of feedback therapy stimulation parameters to facilitate the transformation research of acupuncture.关键词：electroencephalogram （EEG）;microstate;acupuncture effect;clustering analysis;time series;neurophysiology
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发布时间：2022-09-26 - 摘要：Annular drainage with electric pyropuncture needle therapy has been gradually applied in clinical practice. The existing studies suggest that its action mechanism is to promote the formation of “protective field” around the wound， control the spread of infection and promote the healing of the wound through full exposure of the wound and adequate drainage. A large number of modern clinical studies have demonstrated that fire needle has the effects of clearing heat and outthrusting pathogens， warming meridians and dredging collaterals， strengthening the healthy qi and eliminating pathogens. After research， it is believed that annular drainage with electric pyropuncture needle therapy plays an indispensable role in accelerating the healing of wounds because in the treatment of abscesses it can not only provide adequate drainage and establish a protective field， induce heat to expel pathogens， which exist in the deep layer of skin and thick flesh， but also mobilize the body’s healthy qi to resist external pathogens and prevent recurrence.关键词：electric pyropuncture needle therapy;annular drainage;abscess;induce heat to expel pathogens;strengthen the healthy qi and eliminate pathogens;wound healing
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发布时间：2022-09-26 - 摘要：Based on the theory of “restraining excessiveness to acquire harmony”， a viewpoint of “using homeopathy according to rehabilitation mechanism”for the treatment of primary immune thrombocytopenia （ITP） was proposed. It was believed that the “self-stabilization function of rehabilitation mechanism” of the body itself was the significant force to effectively contain and even eliminate the “harm of excessive disorder” of ITP， and medical intervention should follow the therapeutic principle of “going with the flow and helping its strength”. “Going with the flow” was to directly help the self-stability function of the body by inheriting “self-stabilization function of rehabilitation mechanism”， and the main method was to “regulate qi and blood， reconcile blood and vessels”. “Helping its force” was to indirectly help the self-stability function of the body by inheriting “self-stabilization function of rehabilitation mechanism”， and the main method was to “symptomatic treatment and annihilating reinforcements”.关键词：primary immune thrombocytopenia;restraining excessiveness to acquire harmony;self-stabilization function of rehabilitation mechanism;going with the flow;traditional Chinese medicine therapy
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发布时间：2022-09-26 - 摘要：ObjectiveTo systematically evaluate the clinical effect of acupuncture-related therapies in the treatment of premature ovarian failure （POF）.MethodsPubmed， Embase， Cochrance Library， Chinese Biology Medicine disc （CBM）， China National Knowledge Infrastructure （CNKI）， Wanfang Database （WangFang） and VIP Database （VIP） were searched by computer from the date of database establishment to April 6， 2020， and the randomized controlled trials （RCTs） of acupuncture-related therapies in treating POF were screened. Two investigators independently screened the literature， extracted data and evaluated the bias risk of the inclusion study. The stata 15.1 software were applied for the statistical analysis of data and plotting.ResultsA total of 32 RCTs were included involving 11 treatment methods， including： acupuncture combined with moxibustion， western medication， Chinese medicinal herbs + moxibustion， acupoint catgut embedding， acupuncture combined with medication， acupoint catgut embedding + medication， acupuncture-moxibustion + medication， Chinese medicinal herbs， moxibustion， acupuncture， Chinese medicinal herbs + acupuncture-moxibustion + auricular point therapy. The network Meta-analysis results showed that， in the aspect of clinical effect， the effect of acupoint catgut embedding was the best， acupuncture-related therapies were superior to Chinese medicinal herbs or western medication only， and the top five treatment methods were acupoint catgut embedding （85.4%）， acupuncture combined with moxibustion （70.3%）， acupuncture （63.1%）， Chinese medicinal herbs + acupuncture-moxibustion + auricular point therapy （61.6%）， acupoint catgut embedding + medication （55.4%）； in the aspect of decreasing the level of serum follicle stimulating hormone（FSH）， the effect of acupuncture was more significant， acupuncture-related therapies were superior to Chinese medicinal herbs or western medication only， and the top five treatment methods were acupuncture （97.7%）， acupoint catgut embedding （82.2%）， acupuncture combined with moxibustion （61.9%）， Chinese medicinal herbs + acupuncture-moxibustion + auricular point therapy （60.3%）， acupoint catgut embedding + medication （57.2%）.ConclusionIn the aspects of enhancing the clinical effect and reducing the level of serum FSH， the effect of acupuncture-related therapies are more significant than that of Chinese medicinal herbs or western medication only. While due to the limitations of the existing studies， the conclusion of this study needs to be confirmed by a large number of high-quality RCTs with reasonable design and proper methods.关键词：premature ovarian failure;acupuncture-related therapy;Chinese medicinal herbs;network Meta-analysis
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发布时间：2022-09-26 - 摘要：ObjectiveTo explore the effects of different metabolic states and obesity on sex hormone level and the distribution of traditional Chinese medicine （TCM） body constitutions and syndromes in patients with polycystic ovary syndrome （PCOS）.MethodsBased on different status of metabolic syndrome （MS） and obesity， PCOS patients were divided into metabolically healthy obesity （MHO） group， metabolically unhealthy obesity （MUHO） group， metabolically healthy non-obesity （MHNO） group and metabolically unhealthy non-obesity （MUHNO） group. The differences of insulin metabolism related indexes， blood lipid metabolism related indexes， sex hormone level and clinical characteristics in each group were compared， and the distribution of TCM body constitutions and syndromes in each group were observed， and the multinomial logistic regression model was adopted to explore the correlation between relevant indexes and different metabolic states and obesity.Results①A total of 1，462 PCOS patients were included， including 304 cases in the MHO group， 127 cases in the MUHO group， 972 cases in the MHNO group and 59 cases in the MUHNO group. ②Patients in the MHNO group had higher luteinizing hormone （LH） and dehydroepiandrosterone sulfate （DHEAS） levels， higher LH/FSH ratio and higher incidence of LH/ follicle-stimulating hormone （FSH） ratio greater than 2.5 than those in the MHO group and MUHO group （P<0.05）， higher sex hormone-binding globulin （SHBG） levels， higher incidence of lipid overflow and insulin resistance （IR） and higher dyslipidemia than those in the other three groups （P<0.05）， and lower free androgen index （FAI）， lower lipid accumulation product （LAP）， lower visceral adiposity index （VAI）， lower insulin resistance index （HOMA-IR）， and lower homeostatic model β-cell secretory function index （HOMA-β） than those in the other three groups （P<0.05）. Patients in the obese groups had higher scores in the scale of acanthosis nigricans than those in the non-obese groups （the MHNO group， the MUHNO group） （P<0.05）. Patients in the MUHO group had lower incidence of hyperandrogenemia than those in the MH groups （the MHO group， the MHNO group） （P<0.05）. ③Patients in the MHO group， MUHO group and MUHNO group were predominantly diagnosed with phlegm-damp constitution and qi-deficiency constitution， while patients in the MHNO group were predominantly diagnosed with phlegm-damp constitution， qi-deficiency constitution， neutral constitution and yang-deficiency constitution. ④In terms of TCM syndrome distribution， patients in the MHO group and MUHO group were mainly diagnosed with spleen-deficiency and phlegm-dampness syndrome， intermingled phlegm and blood stasis syndrome， patients in the MHNO group were often diagnosed with kidney deficiency and liver depression syndrome， and patients in the MUHNO group were most diagnosed with intermingled phlegm and blood stasis syndrome. ⑤The incidence of MHO was positively correlated with LAP and negatively correlated with VAI； The incidence of MUHO was positively correlated with LAP， VAI and dyslipidemia； The incidence of MUHNO was positively correlated with LAP， LH/FSH ratio greater than 2.5 and dyslipidemia， and negatively correlated with LH/FSH ratio.ConclusionMHO People with PCOS still have a higher risk of developing MS and are more likely to develop related complications than MHNO people with PCOS. Therefore， special attention should be paid to the metabolic state and obesity.关键词：polycystic ovary syndrome;metabolic syndrome;sex hormone;obesity;body constitution;traditional Chinese medicine syndrome
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发布时间：2022-09-26 - 摘要：ObjectiveTo systematically evaluate the clinical efficacy of modified Xiaochaihu Decoction in the treatment of depression.MethodsThe literature of randomized controlled trials （RCTs） of depression treated with modified Xiaochaihu Decoction was collected through computer search of Chinese and English databases， whose publication time was from the date of database establishment to April 14， 2021. The quality of literature was evaluated with the help of Cochrane reviewers Handbook 6.0 software， and RevMan 5.3 software was used for data processing and analysis.ResultsNine RCTs involving 671 patients were finally included in this study， with 341 cases in the treatment group and 330 cases in the control group. Meta-analysis results showed that the total effective rate of the treatment group was significantly higher than that of the control group ［RR=1.22， 95% CI （1.14， 1.32）， P<0.000 01］， and the treatment group could better reduce the HAMD score ［MD=-3.81， 95% CI（-5.63，-1.99）， P<0.000 1］. Totally 20 adverse reactions/events were reported， all of which were mild.ConclusionsCompared with the single use of antidepressants， either the single use of modified Xiaochaihu Decoction or the combined use of modified Xiaochaihu Decoction with antidepressants can achieve better clinical efficacy in the treatment of depression. However， due to factors such as the quality and quantity of the collected literature， the conclusion remains to be further validated.关键词：Xiaochaihu Decoction;depression;Hamilton Depression Scale;Meta-analysis
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发布时间：2022-09-26 - 摘要：Considering the relationships among the spirit， visceral organs， qi and blood， meridians and vessels， the clinical experience of needling （mainly Huici） abdominal scars （tendon nodules） for the treatment of insomnia was discussed by combining the treatment of “spirit” based on the holistic syndrome differentiation with the local syndrome differentiation and treatment based on meridian-tendon theory. In the acupuncture clinical practice， the holistic differentiation should be integrated into the local diagnosis and the local differentiation should assist the holistic diagnosis in order to achieve satisfactory effects. A proven case was attached below.关键词：acupuncture;meridian-tendon therapy;tendon nodule;treating “spirit”;insomnia;medical record
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发布时间：2022-09-26 - 摘要：The purpose of this paper is to explore Professor Li Qiuyan’s experience in the treatment of senile intractable insomnia. Professor Li believes that the core pathogenesis of senile intractable insomnia is depletion of Tiangui， imbalance between yin and yang， emotional disorder and internal retention of blood stasis. Professor Li is good at the flexible use of Chinese medicines for activating blood and resolving stasis， emphasizing the treatment based on syndrome differentiation， precise use of Chinese medicines， and the combination of using Chinese medicines for tranquilizing spirit by heavy settling and nourishing the heart to tranquilize spirit， and advocating the simultaneous treatment of the heart and the liver as well as the heart and mind. And two proven cases are presented.关键词：intractable insomnia;elderly people;clinical experience;activating blood and resolving stasis;simultaneous treatment of the heart and the liver
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发布时间：2022-09-26 - 摘要：This paper expounds the understanding of “Bu Ke Yu Yao” in the clauses of Treatise on Exogenous Febrile Diseases. The two annotations of the clause in the unified textbook are “do not use other drugs” and “non-residual dregs of a decoction”. By using the method of hermeneutic cycle within clauses， between clauses and between texts， the meaning of “Bu Ke Yu Yao” is studied and evaluated in this paper. Through the analysis of the syndrome of Didang Pill， entering the hermeneutic cycle of TCM classical text understanding and clinical practice interpretation and achieving the hermeneutic goal of practice， it is found that its meaning should be “do not overuse drugs”.关键词：Bu Ke Yu Yao;hermeneutics;Treatise on Exogenous Febrile Diseases;terms of traditional Chinese medicine;research on prescription and syndrome
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发布时间：2022-09-26 - 摘要：The purpose of this paper is to expound the relationship among kidney essence， intestinal flora and brain function from the point of view of source， physiology， pathology and treatment， and it is believed that the relationship between kidney essence and brain function and the relationship between intestinal flora and brain function are highly consistent. Both kidney essence and intestinal flora are formed in the embryonic stage， affected by acquired factors， and both can promote the development of nervous system and maintain the physiological function of brain. Deficiency of kidney essence and imbalance of intestinal flora can cause central nervous system disease， so encephalopathy can be treated by tonifying the kidney and replenishing essence and regulating intestinal flora.关键词：kidney essence;intestinal flora;brain;central nervous system
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发布时间：2022-09-26 - 摘要：Through a brief exposition of the theory of ascending clearness and descending turbidity and brain function of traditional Chinese medicine， in combination with relevant literature and modern clinical application， and taking the clinical application of ascending clearness and descending turbidity theory in stroke， vertigo， headache， insomnia， depression syndrome， amnesia as examples， this paper discussed that the theory of ascending clearness and descending turbidity should be fully used to guide the diagnosis and the treatment of encephalopathy， so as to improve the clinical efficacy of traditional Chinese medicine in the treatment of encephalopathy.关键词：ascending clearness and descending turbidity;encephalopathy;clinical application
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发布时间：2022-09-26 - 摘要：ObjectiveTo observe the clinical efficacy of acupuncture combined with conventional therapy for antipsychotic drug-induced metabolic syndrome.MethodsNinety-three schizophrenia patients complicated with metabolic syndrome of qi deficiency and phlegm stagnancy syndrome were randomly divided into a control group （n=46） and a treatment group （n=47）. The control group was administered with conventional medication and lifestyle interventions， while the treatment group was additionally administered with acupuncture treatment besides the treatment measures of the control group. The course of treatment for both groups was 3 months， and the patients were followed up constantly for 6 months after the end of treatment. Our research group also observed and compared the changes of the World Health Organization Quality of Life Assessment-BREF （WHO-QOL-BREF） score， the Global Assessment of Functioning （GAF） score， the Clinical Global Impressions scale （severity of illness and global improvement measures） （CGI-SI） score， Treatment Emergent Symptom Scale （TESS） score， waist circumference， hip circumference， body mass index， blood pressure and other general conditions， as well as the changes of total cholesterol （TC）， triacylglycerol （TG）， high-density lipoprotein （HDL-C）， low-density lipoprotein （LDL-C）， fasting blood glucose （FPG）， glycated hemoglobin （HbA1c） and other lab text indexes.Results①During the trial， there was one drop-out case in each group， and 91 cases finally completed the trial， including 46 cases in the treatment group and 45 cases in the control group. ②During the trial， there were no significant changes in WHO-QOL-BREF， GAF， CGI-SI and TESS scores， body mass index， waist circumference， hip circumference， systolic blood pressure， diastolic blood pressure， and related laboratory indexes in the control group （P>0.05）. ③Patients in the treatment group showed higher GAF scores and WHO-QOL-BREF scores in physical domain and psychological domain （P<0.05）， lower CGI-SI and TESS scores （P<0.05）， and improved lipid-related laboratory indexes （P<0.05） after 3 months. However， the above indexes rebounded to different degrees after 6 months， which were still better than those in the control group （P<0.05）.ConclusionCompared with conventional medication and life interventions， the additional treatment of acupuncture for antipsychotic drug-induced metabolic syndrome has more satisfactory efficacy and can assist the treatment of mental diseases with long-lasting effects.关键词：metabolic syndrome;antipsychotic drugs;schizophrenia;acupuncture
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发布时间：2022-09-26 - 摘要：ObjectiveTo observe the immediate effect of acupuncture at Ximen （PC 4） on coronary flow velocity in patients with coronary slow flow phenomenon （CSFP）.MethodsSeventy patients with CSFP were enrolled as study subjects and randomly divided into a test group （acupuncture at Ximen acupoint） and a control group （acupuncture at sham acupoints）， with 35 cases in each group. The changes in the corrected Thrombolysis in Myocardial Infarction （TIMI） frame count （CTFC） values under use of coronary angiography and traditional Chinese medicine （TCM） symptom scores were observed and compared before and after acupuncture between the two groups， and safety evaluation was also performed.Results①The intragroup comparison showed that after acupuncture the CTFC values in the test group decreased （P<0.05） while the difference of CTFC values in the control group was not statistically significant （P＞0.05）. After acupuncture， the difference of CTFC values in the test group was higher than that in the control group （P<0.05）. ②After acupuncture， the TCM symptom scores of patients in both groups were lowered （P<0.05）； the difference of TCM symptom scores in the test group was higher than that in the control group （P<0.05）. ③No significant adverse reaction was observed in both groups.ConclusionAcupuncture helps to reduce subjective symptoms in patients with CSFP； compared with sham acupuncture， acupuncture at Ximen （PC 4） accelerates coronary blood flow and better improves clinical discomfort in patients with CSFP.关键词：coronary slow flow phenomenon;heart palpitation;chest pain;acupuncture;Ximen （PC 4）;corrected TIMI frame count
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发布时间：2022-09-26 - 摘要：ObjectiveTo observe the clinical efficacy of press needle， repeat functional magnetic stimulation combined with bladder function training and intermittent catheterization in the treatment of urinary incontinence during recovery from stroke.MethodsNinety patients with urinary incontinence during stroke recovery were randomly divided into the treatment group （n=45） and the control group （n=45）. Both groups were treated with conventional and comprehensive internal medicine treatment for stroke and basic nursing for urinary incontinence. The control group was administered with bladder function training and intermittent catheterization， and the treatment group was administered with press needle and repeat functional magnetic stimulation besides the treatment measures of the control group. Both groups were treated continuously for 12 sessions. The changes of urodynamic indexes （residual urine volume， maximum bladder volume， maximum urinary flow rate）， voiding diary indexes （24-h urinary incontinence frequency， 24-h voiding frequency）， overactive bladder symptom score （OABSS）， and quality of life （QOL） score were observed and compared between the two groups.Results①After treatment， the residual urine volume decreased （P<0.05）， and the maximum bladder volume and maximum urinary flow rate increased （P<0.05） in both groups； after treatment， the residual urine volume in the treatment group was lower than that in the control group （P<0.05）， and the maximum bladder volume and maximum urinary flow rate were higher than those in the control group （P<0.05）. ②After treatment， the 24-h voiding frequency and 24-h incontinence frequency decreased in both groups （P<0.05）； After treatment， the 24-h voiding frequency and 24-h incontinence frequency in the treatment group were lower than those in the control group （P<0.05）. ③After treatment， OABSS and QOL scores decreased in both groups （P<0.05）； After treatment， OABSS and QOL scores in the treatment group were lower than those in the control group （P<0.05）.ConclusionCompared with the conventional treatment with bladder function training and intermittent catheterization， the additional use of press needle and repeat functional magnetic stimulation in the treatment of urinary incontinence during stroke recovery has satisfactory results， which can effectively relieve the symptoms of urinary incontinence， improve the urodynamic indexes and the quality of life of patients.关键词：stroke;urinary incontinence;press needle;repeat functional magnetic stimulation;bladder function training;intermittent catheterization
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发布时间：2022-09-26 - 摘要：ObjectiveTo observe the effects of acupressure based on the Shen-Ming theory of traditional Chinese medicine （TCM） combined with conventional cognitive rehabilitation training on cognitive function， activities of daily living and plasma concentrations of β-amyloid 1-42 （Aβ1-42） in patients with post-stroke cognitive impairment.MethodsSixty-six patients with post-stroke cognitive impairment were randomly divided into a control group （n=33） and a treatment group （n=33）. The control group was administered with conventional cognitive rehabilitation training， and the treatment group was additionally administered with TCM Shen-Ming theory-based acupressure besides the treatment measures of the control group. The course of treatment of the two groups lasted 12 weeks， and the changes of Montreal Cognitive Assessment （MoCA） score， activities of daily living （ADLs） scale score and plasma concentrations of Aβ1-42 were observed and compared.ResultsAccording to the intra-group comparison before and after treatment， MoCA scores increased （P<0.05） and ADL scores and the plasma concentrations of Aβ1-42 decreased （P<0.05） in both groups. According to the inter-group comparison after treatment， MoCA score was higher in the treatment group than that in the control group （P<0.05）， the plasma concentrations of Aβ1-42 in the treatment group were lower than the concentrations in the control group （P<0.05）， and there was no significant difference in ADL score between two groups （P>0.05）.ConclusionCompared with the single use of cognitive rehabilitation training， the combined use of TCM Shen-Ming theory-based acupressure and cognitive rehabilitation training has achieved satisfactory results in treating post-stroke cognitive impairment， which can better improve patients’ cognitive function， facilitate activities of daily living and lower plasma concentrations of Aβ1-42.关键词：post-stroke cognitive impairment;cognitive function;acupressure;β⁃amyloid 1-42;Shen-Ming theory;integrated traditional Chinese and Western medicine therapy
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发布时间：2022-09-26 - 摘要：ObjectiveThe aim is to explore the expression differences of orexin receptors in related organs （lung， heart， liver， spleen， kidney， large intestine and brain） between insomnia rats with lung storing no inferior spirit and control rats， so as to enrich the objective experimental basis and the application of five emotion-based classification and diagnosis of insomnia in traditional Chinese medicine.MethodsSixteen rats were randomly divided into the control group and model group， 8 rats in each group. The insomnia rat model was made by small platform-water environment method. The expressions of orexin receptors （OX1R and OX2R） in liver， heart， spleen， lung， kidney， large intestine and brain were detected by immunohistochemistry.Results①Compared with the control group， the expressions of OX2R in lung tissue， OX1R in heart tissue and OX1R and OX2R in brain tissue were significantly up-regulated in the model group， with statistically significant differences （P<0.01）， but there were no statistically significant differences in the expressions of OX1R and OX2R in spleen tissue between the control group and model group （P>0.01）. ②There were no significant expressions of OX1R and OX2R in liver， kidney and large intestine tissues between the two groups.ConclusionThe expressions of OX1R and OX2R in brain tissue， OX2R in lung tissue and OX1R in heart tissue of insomnia model rats are up-regulated， and orexin receptors may be one of the characteristic neurotransmitters in insomnia rats with lung storing no inferior spirit.关键词：five emotion-based classification of insomnia in traditional Chinese medicine;lung storing no inferior spirit;insomnia;orexin receptor;sleep deprivation;model rat
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发布时间：2022-09-26 - 摘要：ObjectiveTo improve the quality standards of Fengshigutong Capsules and improve their quality control level.MethodsThe TLC identification of Ephedra herba， Aconiti Radix Cocta （ARC） and Aconiti Kusnezoffii Radix Cocta （AKC） was conducted by using n-hexane-chloroform-ethyl acetate-methanol （4︰7︰6︰2） as the developing agent and iodine vapor as the developer. The TLC identification of Glycyrrhizae Radix Et Rhizoma （GRER） was conducted by using ethyl acetate-formic acid-glacial acetic acid-water （15︰1︰1︰2） as the developing agent， and 10% sulfuric acid ethanol solution as the developer. The TLC-bioautography identification of Chaenomelis Fructus was conducted by using chloroform-ethyl acetate-acetone-formic acid （8︰2︰2︰0.4） as the developing agent， 2，2-biphenyl-1-picrylhydrazino （DPPH） anhydrous ethanol solution as the developer. The HPLC method was established for the simultaneous determination of benzoylmesaconine （BMA）， benzoylaconine （BAC） and benzoylhypaconine （BHA） and their contents were determined. The HPLC method was established for glycyrrhizic acid and its content was determined.ResultsThe two TLC methods established had clear spots， moderate Rf values， and good resolution. TLC-bioautography achieved the purpose of identifying and characterizing antioxidant active ingredients in Chaenomelis Fructus. The linear ranges of BMA， BAC and BHA in the content determination were 2.200~280.0 μg/mL， 2.370~75.76 μg/mL， 3.180~101.6 μg/mL， respectively. The inner linear relationship was good， correlation coefficient of each index component was greater than 0.9999. The average recovery rates were between 92% and 107% with RSD between 2.85% and 5.62% for BMA， BAC and BHA. The contents of BMA， BAC and BHA in 21 batches of samples were 35.00~80.15 μg， 6.92~13.57 μg， 9.94~17.99 μg per capsule. The linear range of glycyrrhizic acid was 6.100~97.58 μg/mL. The inner linear relationship was good， and the average recovery rate was 100.9% with RSD of 1.95%. The content of glycyrrhizic acid in 21 samples was between 1.70 and 2.21 mg per capsule.ConclusionThe method is accurate， sensitive， specific， and reproducible and it can be used for the quality control of Fengshigutong Capsules.关键词：Fengshigutong Capsules;Quality standard;TLC;TLC-bioautography;HPLC content determination
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发布时间：2022-09-26 - 摘要：In this paper， the research on Limax maximus is reviewed from two aspects of chemical composition and pharmacological activity. Limax maximus contains protein， limax polysaccharide， sterol， monoamine， volatile oil and other active ingredients. Pharmacological studies have shown that they have anti-tumor， anti-inflammatory， antitussive， expectorant， antiasthmatic， antioxidant， antiviral and other functions， which are mainly used for the prevention and treatment of cancer， bronchial asthma， chronic obstructive pneumonia and other diseases.关键词：Limax maximus;chemical constituents;pharmacological effects;review
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发布时间：2022-09-26 - 摘要：The research progress on the mechanism of oxidative stress （OS） in polycystic ovary syndrome （PCOS） and the treatment of traditional Chinese medicine were reviewed. Studies had shown that OS further aggravated metabolic disorders in PCOS patients due to excessive androgen， insulin resistance， mitochondrial dysfunction and inflammation， and affected the intrauterine environment during PCOS pregnancy， resulted in adverse pregnancy outcomes. Traditional Chinese medicine therapy used monomer， compound herbal medicine ， acupuncture and moxibustion to effectively improve the level of OS in patients， in addition to alleviating their clinical symptoms and improving their quality of life.关键词：polycystic ovary syndrome;oxidative stress;reactive oxygen species;traditional Chinese medicine therapy;review
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发布时间：2022-09-26
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