最新刊期
期 9 ， 2021
- 摘要：Professor Chen Yiping traced the source from the theory of Huangdi Neijing and believed that wind pathogen played an important role in the occurrence, transmission, clinical manifestations, prognosis and outcome of kidney disease. Professor Chen tended to treat kidney diseases from the perspective of wind pathogen and flexibly used the treatment methods of differentiating San Jiao, invigorating the spleen, dispelling dampness, treating the blood, using integrated therapy of astringing and dispersing, which is featured by its significant effect.关键词：Huangdi Neijing;nephropathy;wind-based treatment;Chen Yiping
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发布时间：2022-08-03 - 摘要：This paper attempted to provide ideas for the study and clinical practice of Treatise on Febrile Diseases by expounding the problems related to febrile diseases throughout history from the following ten aspects: the prevalence of febrile diseases in the late Han Dynasty, the development of diagnosis and treatment pattern of febrile diseases, the progress of syndrome differentiation rules based on the six meridians, the theoretical inheritance of febrile diseases through texts, the doubts on Treatise on Febrile Diseases in the Jin and Yuan Dynasties, the confrontation of disease nature between cold and warm in the Ming and Qing Dynasties, the cognitive evolution of febrile diseases from a classic concept to an integrated one, the historical echo of modern research on febrile diseases, different name and nature of febrile diseases in different contexts, and the clinical success or failure due to different understanding of febrile diseases in history.关键词：febrile disease;diagnosis and treatment rule;Treatise on Febrile Diseases;clinic practice
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发布时间：2022-08-03 - 摘要：Specific site acupuncture has been widely recognized as an important part of acupuncture therapy. Through many years of research, Professor Li Yongming has found that all the specific acupuncture areas, such as the head, eyes, ears, mouth, abdomen, wrist and ankle, are mast cell aggregation areas, and so is the anal area, but no corresponding specific site acupuncture has been proposed for the anal area. Therefore, professor Li Yongming and professor Wang Fuchun jointly put forward that there is also a corresponding specific site acupuncture for the anal area, namely anus acupuncture as the anal area closely connects with the meridians and zang-fu organs, has a special physiological and anatomical structure and is a mast cell aggregation area. Based on many years of clinical experience of the two experts, a preliminary discussion on the zoning, indications, acupoints and operation essentials of anus acupuncture is made combined with medical records.关键词：anus acupuncture;specific site acupuncture;microneedle therapy;mast cell;urogenital disease;anorectal disease
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发布时间：2022-08-03 - 摘要：ObjectiveTo explore the acupoint selection rules in acupuncture and moxibustion treatment of post-stroke cognitive dysfunction. MethodsThe related literatures on acupuncture and moxibustion treatment of post-stroke cognitive dysfunction published from January 2020 to January 2021 were searched and collected from databases including CNKI, Wanfang Data Knowledge Service Platform and VIP Chinese Journal Service Platform. Microsoft Office Excel worksheet was used to establish a database and perform descriptive statistical analysis; IBM SPSS Modeler 18.0 software was used for correlation analysis of acupoints; and IBM SPSS Statistics 25.0 was used for systematic cluster analysis of acupoints.Results①The included 16 literatures involved 29 acupuncture prescriptions and 62 acupoints with a total use frequency of 233. ②The top 5 acupoints the most frequently used were Shenting (DU 24), Baihui (DU 20), Zusanli (ST 36), Jiaji acupoints of cervical vertebra and Neiguan (PC 6); The meridian with the highest frequency of acupoints selection was Du Meridian, followed by Gallbladder Meridian of Foot Shaoyang, Bladder Meridian of Foot Taiyang and Stomach Meridian of Foot Yangming. ③According to the association rule analysis, the acupoint combinations with strong correlations were Shenting (DU 24) and Benshen (GB 13), Baihui (DU 20), Shuigou (DU 26) and Shenting (DU 24), Shuigou (DU 26), Dazhui (DU 14), Fengfu (DU 16) and Baihui (DU 20). ④A total of 6 clusters of acupoints were obtained by cluster analysis of the 20 acupoints of the highest use frequency.ConclusionAcupuncture and moxibustion treatment of post-stroke cognitive dysfunction mostly selects acupoints from Du meridian, usually Shenting (DU 24) and Baihui (DU 20) as the main acupoints, together with Benshen (GB 13) from Gallbladder Meridian, Zusanli (ST 36) from Stomach Meridian and Neiguan (PC 6) from Jueyin Meridian to open orifices and revive the mind, strengthen the spleen to transform water and dampness, and clear wind-heat to benefit the head and eyes.关键词：stroke;cognitive dysfunction;acupoint selection rule;data mining
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发布时间：2022-08-03 - 摘要：ObjectiveTo summarize the principles of point selection in acupuncture treatment of post-stroke balance dysfunction for the purpose of providing references for clinical practice.MethodsRelated literatures of acupuncture treatment of post-stroke balance dysfunction published from January 1, 2010 to September 1, 2020 were searched and collected from databases including CJFD, Wanfang, VIP, SinoMed, Embase and PubMed to establish acupuncture prescription database. The selection principles of acupoints and meridians were analyzed and summarized through frequency analysis, association rule analysis and cluster analysis.Results①Totally 142 articles were included, involving 167 acupoints with a total frequency of 1,239. ②The most frequently used acupoints were Zusanli (ST 36), Yanglingquan (GB 34) and Quchi (LI 11) in turn, and the most frequently used meridians were Bladder Meridian of Foot Taiyang (BL), Stomach Meridian of Foot Yangming (ST) and Large Intestine Meridian of Hand Yangming (LI) in turn. ③The acupuncture sites mainly focused on the limbs, head, face, neck, nape and back, and Five-Shu points were the most widely used specific points. ④According to the results of association rule analysis, the combination of acupoints with the highest confidence was Ganshu (BL 18)-Shenshu (BL 23), anterior oblique parietotemporal line-lateral line 1 of vertex, and the mutual compatibility of Yangming meridian points. ⑤ Eight main groups were obtained from cluster analysis and the corresponding principles of acupoint selection were also analyzed.ConclusionsAcupuncture treatment of post-stroke balance dysfunction is based on the principle of selecting points along meridians, which mainly selects Yang meridian points. It adopts such treatment methods as "treating flaccidity specifically with Yangming meridian" , "refreshing brain and inducing resuscitation" , "dredging governor vessel and regulating mind" , as well as "dredging meridians and regulating viscera" , and flexibly selects Jiaji points, Back-Shu points, points of Qiao meridians and scalp acupuncture for treatment with the emphasis on the use of Five-Shu points as well.关键词：stroke;balance dysfunction;acupuncture;acupoint selection principle;data mining
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发布时间：2022-08-03 - 摘要：The purpose of this article is to introduce Professor Shi Suofang’s clinical experience in the treatment of internal injuries and miscellaneous diseases by using Taiji Liuqi acupuncture method based on the theory of "opening, closing and pivot of three yin and three yang" . It is considered that "opening, closing and pivot of three yin and three yang" is another manifestation of the movement of qi rising and falling. The method of Taiji Liuqi acupuncture is established based on the theory of opening, closing and pivot, and it is more effective in the treatment of internal injuries and miscellaneous diseases. And 3 proven cases are presented.关键词：internal injuries and miscellaneous diseases;opening, closing and pivot of three yin and three yang;Taiji Liuqi acupuncture method;theory of qi movement;clinical experience;traditional Chinese medicine therapy
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发布时间：2022-08-03 - 摘要：This paper expounded the theoretical basis of treating behavioral and psychological symptoms of dementia (BPSD) from spleen, based on the indirect relationship between spleen and BPSD through the brain marrow, the direct relationship between spleen and BPSD, as well as the modern mechanism study. The therapeutic methods of invigorating the spleen and the stomach, invigorating qi and ascending lucid yang, warming and transporting the spleen yang, nourishing the spleen yin, clearing the spleen and eliminating dampness, invigorating the spleen and resolving turbidity, and promoting blood circulation and dredging collaterals were proposed, and two proven cases were presented.关键词：dementia;behavioral and psychological symptoms;treatment from spleen;proven case
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发布时间：2022-08-03 - 摘要：Professor Cheng Yang’s experience in treating non-alcoholic fatty liver disease (NAFLD) from perspective of depression was introduced. Professor Cheng Yang believed that the incidence of NAFLD was closely related to people’s mental pressure, psychological factors and lifestyle, which could lead to increased incidence of depression, while major depression and generalized anxiety disorder were more common in NAFLD patients, which conformed to the characteristics of "depressive disorder caused by illness" and " illness caused by depression" . Therefore, the treatment of NAFLD was mainly to soothe the liver, regulate qi and relieve depression. Meanwhile, it was combined with sports and psychological therapy.关键词：depression syndrome;non-alcoholic fatty liver disease;soothing the liver, regulating qi and relieving depression;depressive disorder caused by illness;illness caused by depression
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发布时间：2022-08-03 - 摘要：The ancient clinical application of Scutellariae Radix could be divided into "kuqin" and "tiaoqin" , their position, ways, compatibility, usage and dosage in heat clearing were different. Reasonable selection of Scutellariae Radix varieties was particularly necessary to improve the clinical efficacy. Kuqin was good at clearing heat, eliminating heat-toxin. It was often compatible with clearing heat medicine, clearing heat and detoxicating medicine and relieving cough medicine, which mainly used in treating middle and upper Jiao fire-heat syndrome and skin sores. And kuqin was usually processed with wine, and the dosage should be reduced. Tiaoqin was good at clearing dampness and heat, cooling blood heat. It was often compatible with clearing heat and cooling blood medicine, draining water and dispersing dampness medicine, which mainly used in treating middle and lower Jiao dampness-heat syndrome and blood-heat hemorrhagic syndrome. And tiaoqin was used in raw or processed with bile, and the dosage should be increased.关键词：Scutellariae Radix;kuqin;tiaoqin;clearing heat;clinical application
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发布时间：2022-08-03 - 摘要：By studying the knowledge of scholars from China and Japan on Treatise on Exogenous Febrile Diseases, the authors’ different views are expressed. It is believed that "exterior-interior and inside-outside" have their own meanings and cannot be mixed. "Exterior-interior" refers to syndromes, and "inside-outside" refers to symptoms. "Exterior-interior" refers to the subjective summary of all external or internal symptoms, and "inside-outside" refers to a description of a specific objective symptom. It is considered that the "external syndrome" in Treatise on Exogenous Febrile Diseases is "external symptoms of the human body" .关键词：Treatise on Exogenous Febrile Diseases;exterior-interior and inside-outside;external syndrome
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发布时间：2022-08-03 - 摘要：ObjectiveTo compare the clinical efficacy between electroacupuncture pudendal nerve stimulation and normal electroacupuncture in treating postpartum stress urinary incontinence (SUI).MethodsA total of 75 patients with postpartum SUI were randomly divided into three groups with treatments of Kegel exercises (control group), normal electroacupuncture combined with Kegel exercises (therapy group 1), and electroacupuncture pudendal nerve stimulation combined with Kegel exercises (therapy group 2), respectively. The treatment course was 8 weeks in each group. After the treatment, the scores of International Consultation on Incontinence Questionnaire-Short Form (ICI-Q-SF), 1 h urine pad tests, pelvic muscle strength and clinical efficacy were observed.Results①After 4 weeks and 8 weeks treatment, compared with before treatment, there were statistically significant differences in ICI-Q-SF scores among 3 groups (P<0.05); after 4 weeks and 8 weeks treatment, compared with control group, there were statistically significant differences in ICI-Q-SF score in therapy group 1 and therapy group 2 (P<0.05); after 8 weeks treatment, there was a statistically significant difference in ICI-Q-SF score between therapy group 1 and therapy group 2 (P<0.05). ②After 4 weeks and 8 weeks treatment, compared with before treatment, there were statistically significant differences in 1 h urine leakage among 3 groups (P<0.05); after 8 weeks treatment, compared with control group, there were statistically significant differences in 1 h urine leakage in therapy group 1 and therapy group 2 (P<0.05); after 8 weeks treatment, there was a statistically significant difference in 1 h urine leakage between therapy group 1 and therapy group 2 (P<0.05). ③After 4 weeks and 8 weeks treatment, compared with before treatment, there were statistically significant differences in Ⅰand Ⅱ type pelvic muscle strength among 3 groups (P<0.05); after 8 weeks treatment, compared with control group, there were statistically significant differences inⅠand Ⅱ type pelvic muscle strength in therapy group 1 and therapy group 2 (P<0.05); after 4 weeks and 8 weeks treatment, there was no significant difference in Ⅰand Ⅱ type pelvic muscle strength between therapy group 1 and therapy group 2 (P>0.05). ④The total effective rate of the control group, therapy group 1 and therapy group 2 were 40.0%, 72.0%, 88.0% respectively, and the clinical efficacy of therapy group 1 and therapy group 2 were better than that of control group (P<0.05), in addition, the clinical efficacy of therapy group 2 was better than that of therapy group 1(P<0.05). ConclusionElectroacupuncture pudendal nerve stimulation combined with Kegel exercises was better than normal electroacupuncture combined with Kegel exercises and simple Kegel exercises in treating postpartum SUI.关键词：postpartum stress urinary incontinence;electroacupuncture pudendal nerve stimulation;electroacupuncture;Kegel exercises;clinical trials
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the clinical efficacy of Shengyang Tongdu acupuncture combined with electromyographic (EMG) biofeedback training in the treatment of cerebral infarction and its effect on patients’ electroencephalography (EEG) topography, neurovascular unit function and heart rate variability (HRV).MethodsNinety patients with cerebral infarction were randomly divided into a treatment group (n=45) and a control group (n=45). Both groups underwent basic neurological treatment, while the control group was additionally given EMG biofeedback training and the treatment group was additionally given Shengyang Tongdu acupuncture treatment and EMG biofeedback training. The treatment course was 4 weeks in both groups. The safety of the treatment measures was assessed, and the changes in the stroke related scale scores, traditional Chinese medicine (TCM) syndrome scores, heart rate variability related indexes, EEG topography related indexes and neurovascular unit function related indexes were compared. Results①Finally 83 cases completed the trial, 42 cases in the treatment group and 41 cases in the control group. ②After treatment, the improvement of National Institutes of Health Stroke Scale (NIHSS) score, Fugl-Meyer score, and Bartherl index in the treatment group was significantly better than that in the control group (P<0.05). ③After treatment, the standard deviation of all normal to normal NN intervals (SDNN), the square root of the mean of the squares of successive NN interval differences (RMSSD) and the percentage of NN intervals >50 ms different from preceding interval (PNN50) of heart rate, and the levels of serum matrix metalloproteinase-9 (MMP-9), vascular endothelial growth factor (VEGF) and transforming growth factor-β1 (TGF-β1) in the treatment group were significantly higher than those in the control group (P<0.05); the improvement of power voltage in the beta (β), delta (δ) and theta (θ) bands of the brain in the treatment group were significantly better than those in the control group (P<0.05). ④After treatment, the TCM syndrome scores were significantly lower in both groups (P<0.05); the difference of TCM syndrome scores before and after treatment in the treatment group was significantly higher than that in the control group (P<0.05). ⑤No case of serious adverse reactions was found in both groups.ConclusionShengyang Tongdu acupuncture with EMG biofeedback training for cerebral infarction can significantly alleviate clinical symptoms, promote the recovery of nerve function and improve patients’ ability of life, and the mechanism may be related to the improvement of brain electrophysiological activity, neurovascular unit function and autonomic nervous system function.关键词：cerebral infarction;stroke disease;Shengyang Tongdu method;acupuncture;electromyographic biofeedback training;electroencephalography topography;neurovascular unit;heart rate variability
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the clinical effect of acupuncture and medication combined prevention and treatment of migraine of liver-yang hyperactivity syndrome based on the method of clearing liver and purging fire.MethodsA total of 159 patients with migraine of liver-yang hyperactivity syndrome were randomly divided into traditional Chinese herbal medicine (TCHM) group, acupuncture and medication combined (AMC) group 1 and AMC group 2, with 53 cases in each group. The TCHM group was administered with Qinggan Huayu Prescription, the AMC group 1 was administered with Qinggan Huayu Prescription together with conventional acupuncture, and the AMC group 2 was administered with Qinggan Huayu Prescription together with liver-clearing and fire-purging acupuncture therapy. The course of treatment in each group was 8 weeks, with 4 weeks of follow-ups after treatment. The clinical effect was observed, and the changes of migraine symptoms (headache attack frequency, headache duration, headache degree, accompanying symptoms) scores and traditional Chinese medicine (TCM) syndrome scores before and after treatment were compared.Results①During the trial, there were 4 drop-out cases in the TCHM group, 7 drop-out cases in the AMC group 1, and 6 drop-out cases in the AMC group 2. Finally, 142 cases completed the trail, including 49 cases in the TCHM group, 46 cases in the AMC group 1, and 47 cases in the AMC group 2. ②The effective rate of TCHM group, AMC group 1 and AMC group 2 was 57.41%, 76.09%, and 95.74%, respectively. According to the inter-group comparisons, the AMC group 1 and AMC group 2 showed better clinical effects than the TCHM group (P<0.05), and AMC group 2 had even better clinical effects than AMC group 1 (P<0.05). ③According to the intra-group comparisons before treatment and after 4 weeks of treatment, 8 weeks of treatment, and 4 weeks of follow-ups, the scores of TCM syndromes, the total scores of migraine symptoms, and the scores of various items (headache attack frequency, headache duration, headache degree, and accompanying symptoms) all decreased in each group (P<0.05). ④The inter-group comparisons after 4 weeks of treatment showed that the differences in the total score of migraine symptoms and the score of headache degree of the AMC group 1 and the AMC group 2 were greater than those of the TCHM group (P<0.05), and the difference in the score of headache degree of the AMC group 2 was greater than that of the AMC group 1 (P<0.05). According to the inter-group comparisons after 8 weeks of treatment and 4 weeks of follow-ups, the differences in scores of headache attack frequency, headache duration, headache degree, total scores of migraine symptoms and TCM syndrome scores of AMC group 1 and AMC group 2 were greater than those of TCHM group (P<0.05), and the differences in scores of headache attack frequency, headache duration, headache degree, total scores of migraine symptoms and TCM syndrome scores of AMC group 2 were greater than those of AMC group 1 (P<0.05).ConclusionThe liver-clearing and fire-purging based acupuncture combined with medication has achieved satisfactory results in preventing and treating migraine of liver-yang hyperactivity syndrome as it can effectively reduce the number of migraine attacks, shorten the duration of headache, relieve the degree of headache and improve TCM syndromes.关键词：migraine;clearing liver and purging fire;acupuncture;Qinggan Huayu Prescription
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the preventive effect of external application of Natrii Sulfas on post-ERCP pancreatitis (PEP) in children.MethodsA total of 150 children with cholangiopancreatic diseases undergoing ERCP were randomly divided into treatment group (n=75) and control group (n=75). ERCP was performed according to the operation standard in both groups. In the treatment group, Natrii Sulfas was applied externally 30 minutes before operation and continued to be used until 24 hours after operation. The incidence of PEP was observed, and the postoperative VAS pain score and the changes of blood tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), diamine oxidase (DAO) and D-lactic acid were compared.Results①The incidence of PEP in the treatment group and the control group was 5.3% and 18.7% respectively, and the incidence of PEP in the treatment group was lower than that in the control group (P<0.05). ②The VAS pain score in the treatment group was lower than that in the control group 24 hours after operation (P<0.05). ③Compared with the results 3 hours before operation, the levels of blood TNF-α and IL-6 increased and the levels of DAO and D-lactic acid decreased in both groups 24 hours after operation (P<0.05). Otherwise, the levels of blood TNF-α, IL-6, DAO and D-lactic acid in the treatment group were lower than those in the control group 24 hours after operation (P<0.05).ConclusionsExternal application of Natrii Sulfas can effectively prevent the incidence of PEP, relieve post-ERCP pain and protect pancreatic tissues to some extent. The mechanism may be related to its functions of improving inflammatory response and protecting intestinal mucosal barrier.关键词：ERCP;post-operation;pancreatitis;children;Natrii Sulfas;external application;inflammation;mucosal barrier
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the clinical efficacy of tuina therapy of regulating the lung and activating the spleen in the treatment of chronic cough (syndrome of lung and spleen qi deficiency) in children with mycoplasma pneumoniae infection.MethodsTotally 72 children with chronic cough (syndrome of lung and spleen qi deficiency) after mycoplasma pneumoniae infection were randomly divided into the treatment group (n=36) and the control group (n=36). The control group was treated with azithromycin, and the treatment group was treated with tuina therapy of regulating the lung and activating the spleen combined with azithromycin. The course of treatment in both groups was 14 days. The clinical efficacy was observed. The changes of daytime cough score, nocturnal cough score, the total score of the cough and secondary symptom score were compared.Results① A total of 71 cases completed the trial, including 35 cases in the treatment group and 36 cases in the control group. ② The total main symptom effective rate and the total effective rate of secondary symptoms in the treatment group were 100.0% and 94.3% respectively, while those in the control group were 83.3% and 66.7% respectively. The clinical efficacy, the efficacy on the main symptoms and the efficacy on the secondary symptoms of the treatment group were better than those of the control group (P<0.05). ③There were significant differences in the daytime cough score, nocturnal cough score, the total scores of cough and secondary symptom score within the two groups before and after treatment (P<0.05), and there were significant differences in daytime cough, nocturnal cough, the total scores of cough and secondary symptom score between the two groups after treatment (P< 0.05).ConclusionThe tuina therapy of regulating the lung and activating the spleen is effective in the treatment of chronic cough (syndrome of lung and spleen qi deficiency) after mycoplasma pneumoniae infection, and it is worth popularizing.关键词：chronic cough after mycoplasma pneumoniae infection;children;deficiency of lung and spleen;tuina method of regulating lung and activating spleen
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the effects of electroacupuncture at pericardium meridian acupoints on the expression of N-methyl-D-aspartate receptor 1 (NR1) and the concentration of intracellular Ca2+ in rats with middle cerebral artery occlusion (MCAO) and to explore the mechanism of cerebral ischemic nerve repair.MethodsNinty SPF grade SD rats were randomly divided into normal group, sham operation group, model group, pericardium meridian group and lung meridian group, with 18 rats in each group. The left MCAO model was prepared by inserting thread into external carotid artery. Acupoints such as "Tianquan (PC 2)" , "Quze ( PC 3)" , "Neiguan (PC 6)" and "Daling ( PC 7)" in the pericardium meridian and "Tianfu (LU 3)" , "Zhize (LU 5)" , "Lieqian (LU 7)" and "Taiyuan (LU 9)" in the lung meridian were taken. Electroacupuncture treatment was started in the pericardium meridian and lung meridian groups on the second day after successful modeling, and treatment was conducted for 3 days, 30 min each time, while the other groups were only bound and fixed for 30 min.The volume of infarcted brain tissue, NR1 positive expression and intracellular Ca2+ content in brain tissues were detected by TTC staining, immunohistochemistry and flow cytometry, respectively, with 30 samples in each group.Results(1) BWT score. ①Comparison between groups: Before treatment, compared with the normal group and the sham operation group, the scores of the model group, the lung meridian group and the pericardium meridian group decreased significantly (P<0.05); compared with the normal group, the sham operation group and the model group, the score of pericardium meridian group increased significantly (P<0.05), but there was no significant difference between the pericardium meridian group and the lung meridian group (P>0.05). ②Comparison within groups: the scores of the lung meridian group and the pericardium meridian group increased significantly compared with those before treatment (P<0.05). (2) Comparison of cerebral infarction volume. Compared with the normal group and the sham operation group, the volumes of the model group, the lung meridian group and the pericardium meridian group were larger, and the difference was statistically significant (P<0.05), indicating that the model of MCAO was successful. There was no significant difference among the model group, the lung meridian group and the pericardium meridian group (P> 0.05). (3) Expression of NR1 in brain tissue. Compared with the normal group, the positive expression of NR1 in the model group, the lung meridian group and the pericardium meridian group increased significantly (P<0.05). Compared with the sham operation group, the positive expression of NR1 in the model group and the lung meridian group increased significantly (P<0.05), but there was no significant difference in NR1 expression in the pericardium meridian group (P>0.05). Compared with the model group, the positive expression of NR1 in the pericardium meridian group was significantly lower (P<0.05). (4) Intracellular Ca2+ content. Compared with the normal group and the sham operation group, Ca2+ content in the model group, the lung meridian group and pericardium meridian group increased significantly (P<0.05). Compared with the model group, the content of Ca2+ in lung meridian group and pericardium meridian group decreased, and the difference was statistically significant (P<0.05).ConclusionElectroacupuncture of acupoints in pericardium meridian can improve the degree of nerve injury in MCAO rats, which may be related to the reduction of NR1 overexpression, the decrease of intracellular Ca2+ concentration, the alleviation of injury on neuron by excitatory toxicity, and the promotion of nerve injury repair.关键词：electroacupuncture;pericardium meridian acupoints;MCAO;model rats;NR1;Ca2+
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发布时间：2022-08-03 - 摘要：ObjectiveTo explore whether Cai’s Neiyi Prescription treats endometriosis by acting on pyroptosis mediated by TRIM24/NLRP3 inflammasome.MethodsSD female rats, six rats were randomly selected as normal control group and six rats as sham operation group. After established the endometriotic model by endometrial autotransplantation method, model rats were randomly divided into model group, gestrinone group (0.25 mg/kg), and low-dose group (11.4 g/kg) and high-dose group(22.8 g/kg) of Cai’s Neiyi Prescription, with 6 rats in each group. After three weeks of intragastric administration, the endometrium of each group was stained with HE for observing the tissue morphology. Meanwhile, immunohistochemistry(IHC) was used to detect the expression of TRIM24, and Western blot was used to detect the protein expression of TRIM24 and NLRP3 inflammasome-mediated pyroptotic proteins, and ELISA was used to detect the concentration of IL-1β and IL-18 in the supernatant fluid of endometrial tissues. there was no significance in the morphology of endometrial tissues, TRIM24 expression, the protein expression of NLRP3 inflammasome-mediated pyroptotic proteins and the concentration of IL-1β and IL-18 in the sham operation group. Compared with the sham operation group, the epithelial layers were thickened and irregular, and TRIM24 expression was significantly decreased (P<0.001), while the protein expression of NLRP3 inflammasome-mediated pyroptotic proteins was obviously increased, and the concentration of IL-1β and IL-18 was significantly elevated (P<0.001) in the model group. Compared with the model group, the epithelial layers were thinned and regular, and TRIM24 expression was significantly promoted (P<0.001, P<0.01), while the protein expression of NLRP3 inflammasome-mediated pyroptotic proteins was obviously decreased, and the concentration of IL-1β and IL-18 was obviously reduced (P<0.001) in the gestrinone group and high-dose group of Cai’s Neiyi Prescription. Compared with the gestrinone group, epithelial cells were increased in the low-dose group of Cai’s Neiyi Prescription, and stromal cells were elevated in the high-dose group of Cai’s Neiyi Prescription. Compared with the low-dose group of Cai’s Neiyi Prescription, the epithelial layers were thinned, and expression of TRIM24 in the stromata was notably promoted, but the protein expression of Pro-IL-1β was reduced significantly (P<0.01) in the high-dose group of Cai’s Neiyi Prescription.ConclusionCai’s Neiyi Prescription with high dose can significantly up-regulate TRIM24, and inhibit NLRP3 inflammasome-mediated pyroptosis in ectopic endometrial tissues.关键词：Cai’s Neiyi Prescription;endometriosis;model rats;TRIM24;NLRP3 inflammasome;IL-1β;IL-18;traditional Chinese herbal medicine research
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发布时间：2022-08-03 - 摘要：ObjectiveTo observe the effect of Danggui Shaoyao Powder on liver function, liver and serum triglyceride (TG) and liver histomorphology of non-alcoholic fatty liver mice.MethodsForty male mice were randomly divided into normal diet group (n=10) and hyperlipidemia-hyperglycemia group (n=30). After the successful establishment of the model, the mice in the hyperlipidemia-hyperglycemia group were randomly divided into model group, Danggui Shaoyao Powder group and obeticholic acid group. The mice in the Danggui Shaoyao Powder group (25.8 g/kg) and the obeticholic acid group (0.6 mg/kg) were given the corresponding drugs by intragastric administration. The mice in the normal group and the model group were fed with the same amount of drinking water. The samples were taken after 6 weeks. The body weight, liver wet weight, liver and serum triacylglycerol levels, fasting insulin (FINS) content, fasting blood glucose (FBG) content, insulin resistance index (HOMA-IR), serum ALT and AST levels, liver histopathology and liver tissue NAS score were measured.ResultsCompared with the model group, the body weight and wet weight of the liver, the levels of TG in the liver and serum, the activities of ALT and AST in serum, FBG, FINS and HOMA-IR in serum, and the total score of NAS in the liver tissue in Danggui Shaoyao Powder group were significantly lower than those in model group (P<0.01).ConclusionDanggui Shaoyao Powder can effectively inhibit liver fat deposition and reduce liver inflammatory injury in mice.关键词：Danggui Shaoyao Powder;non-alcoholic fatty liver;model mice;blood lipids;traditional Chinese herbal medicine research
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发布时间：2022-08-03 - 摘要：ObjectiveTo study the effect of self-made Yiqi Huayu Bushen Recipe on β-catenin signaling pathway and its mechanism for knee osteoarthritis.MethodsThe mouse model of knee osteoarthritis was established by modified Hulth method, which is used to cut the medial skin of the right knee, clip the medial collateral ligament, cut off the medial meniscus and clip the anterior cruciate ligament. Then the mice were divided into model group and self-made Yiqi Huayu Bushen Recipe group. In the sham operation group, the medial skin of the right knee was cut. Two months after the establishment of the model, the mice in the self-made Yiqi Huayu Bushen Recipe group were given the self-made Yiqi Huayu Bushen Recipe by gavage for 2 months. The mice were killed after 2 months of treatment, and the knee joints were taken for detection of related indexes, such as Micro-CT scan images, the changes of chondrocytes in knee joints by ABH/OG staining, protein expressions of β-catenin, MMP-13, Col X by immunohistochemical staining, gene expressions of Col X, MMP-9, MMP-13 and OC by RT-PCR reaction.Results① Micro-CT detection found that compared with the sham operation group, the formation of osteophytes around the knee joint in the model group was increased, and the formation of osteophytes in the self-made Yiqi Huayu Bushen Recipe group was less than that in the model group. ② ABH/OG staining found that in the sham operation group, the surface of articular cartilage was smooth, and the superficial layer, transitional layer, radioactive layer and calcified layer were clear and recognizable. The chondrocytes were arranged in columnar shape, and no chondrocytes nested. In the model group, the number of cells in the superficial layer of articular cartilage tissue decreased, and a large number of cartilage cells nested in the transitional layer and radioactive layer. The tidal line moved forward, and a double tidal line appeared. The articular cartilage morphology in the self-made Yiqi Huayu Bushen Recipe group was significantly improved compared with the model group. ③ β-catenin immunohistochemical staining showed that compared with the sham operation group, the expression of β-catenin protein in articular chondrocytes of the model group was significantly increased, but in self-made Yiqi Huayu Bushen Recipe group the expression was significantly reduced compared with the model group (P<0.05); immunohistochemical staining also found that the expressions of Col X and MMP-13 protein in the articular cartilage tissue of the model group was significantly increased compared with the sham operation group (P<0.05). Compared with the model group, the protein expressions of Col X and MMP-13 in the articular cartilage tissue of self-made Yiqi Huayu Bushen Recipe group was significantly decreased (P<0.05). ④The results of RT-PCR showed that compared with the sham operation group, the gene expressions of Col X,MMP-9, MMP-13 and OC in articular cartilage tissue of the model group were significantly increased (P<0.05). Compared with the model group, the gene expressions of Col X, MMP-9, MMP-13 and OC in self-made Yiqi Huayu Bushen Recipe group were significantly decreased (P<0.05).ConclusionThe self-made Yiqi Huayu Bushen Recipe can treat knee osteoarthritis maybe by decreasing the expression of β-catenin.关键词：knee osteoarthritis;molecular mechanism;β-catenin;Yiqi Huayu Bushen Recipe;model mice;traditional Chinese herbal medicine research
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发布时间：2022-08-03 - 摘要：The research progress on related mechanism regulation by traditional Chinese herbal medicine in pulmonary fibrosis was reviewed. Studies had found that classical prescriptions, compound prescriptions, monomers and active ingredients played a therapeutic role in pulmonary fibrosis on mediating oxidative/anti-oxidative stress, inhibiting epithelial cell-mesenchymal transition, inhibiting endoplasmic reticulum stress, mediating autophagy, improving extracellular matrix deposition and regulating immune balance.关键词：traditional Chinese herbal medicine;pulmonary fibrosis;mechanism;review
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发布时间：2022-08-03 - 摘要：This paper reviewed the research progress on antianxiety active components and mechanism of traditional Chinese herbal medicine. The effective components of traditional Chinese herbal medicine for antianxiety mainly included alkaloids, flavonoids, saponins, iridoid, volatile oil, etc. The mechanism of action included regulating monoamine neurotransmitters and amino acid neurotransmitters, adjusting hypothalamus-pituitary-adrenal axis, improving neuron and brain-derived neurotrophic factor, regulating immune function, and so on.关键词：traditional Chinese herbal medicine;antianxiety;active ingredients;mechanism;review
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发布时间：2022-08-03
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